DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and GLR5

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_565744.1	Gene:	GLR5 / 817801	AraportID:	AT2G32400	Length:	921	Species:	Arabidopsis thaliana

Alignment Length:	936	Identity:	182/936 - (19%)
Similarity:	337/936 - (36%)	Gaps:	252/936 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 TVHGENILAHFEKILSDV-----------IRENLRNGGINVKYFSWNAVR-LKKDFLAAI----- 98
            :|.|.......|..:|||           :|..:.:...||...|:.|.. |:|:.:|.|
plant    41 SVIGRAAKVALEAAVSDVNNDKSFLKETELRLLMEDSACNVFRGSFGAFELLEKEVVAMIGPISS 105

  Fly    99 ----TVTDCENTWNFYKNTQETSILLIAITDSDCPRLPLNRALMVP--IVENGDEFPQLILDAKV 157
                |::|.....:|       .::..|.||      |...||..|  :....::..|:.....:
plant   106 SVAHTISDIAKGLHF-------PLVSFAATD------PTLSALQFPFFLRTTPNDAHQMSALVDL 157

  Fly   158 QQILNWKTAVVFVDQTILEENALLVKSIVHESITNHITPISLILYEINDSLRGQQKRV--ALRQA 220
            .....||..:.......|..|.:   |.:.:.:....:.||   |::..|:...:|.:  ||.::
plant   158 INFYGWKEVISVYSDDELGRNGV---SALDDELYKKRSRIS---YKVPLSVHSDEKFLTNALNKS 216

  Fly   221 LSQFAPKKHEEMRQQFLVISAFHED----IIEIAETLNMF-H----VGNQWMIFVLDMVARDFDA 276
            .| ..|:         :.|..|..|    |.:||:.|.|. |    :...|:...||.::   |.
plant   217 KS-IGPR---------VYILHFGPDPLLRIFDIAQKLQMMTHEYVWLATDWLSVTLDSLS---DK 268

  Fly   277 GTV----------------------TINLDEGANI-AFALNETDPNCQDSLNCTISEISLALVNA 318
            ||:                      |..|....:: |:||:..|         |:..|:..:...
plant   269 GTLKRLEGVVGLRQHIPESVKMEHFTHKLQSNRSMNAYALHAYD---------TVWMIAHGIEEL 324

  Fly   319 ISK-----ITVEEESIYGEISDEEWEAIRFTKQEKQAEILEYMKEFLKTNAKCSSCARWRVETAI 378
            :::     .:..|:.::...:....|.|:|.   ...|:|  :::.||.|.           |.|
plant   325 LNEGINITFSYSEKLLHARGTKLHLEKIKFF---NSGELL--LEKLLKVNF-----------TGI 373

  Fly   379 TWGKSQENRKFRSTPQRDAKNRNFEFIN--------IGYWTPVLGFVCQELAFPHIEHHFRNITM 435
            . |:.|    |.|  .|:....::|.||        :|:|:...||   .:..|...|..:..:.
plant   374 A-GQVQ----FGS--GRNVIGCDYEIINVNKTDVHTVGFWSKNGGF---SVVAPKTRHSQKKTSF 428

  Fly   436 DILTVHNPPWQILT------KNSNGVIVEHKGIVMEIVKELSRALNFSYYLHEASAWKEEDSLST 494
                |.:.....:|      :...|.::......::||  :.|.::|..::      .||.:.|.
plant   429 ----VSDEKLGDITWPGGGREKPRGWVIADSADPLKIV--VPRRVSFVEFV------TEEKNSSH 481

  Fly   495 SAGGNESDELVGSMTFRIPYRV-------------------VEMVQGNQFFIAAVAATVEDPDQK 540
            ...|...|..:.::.| :||.|                   ::||....:..|.....:.....|
plant   482 RIQGFCIDVFIEALKF-VPYSVPYIFEPFGNGHSSPNYNHLIQMVTDGVYDAAVGDIAIVPSRSK 545

  Fly   541 PFNYTQPISVQKYSFITRKPDEVSRIYLFTAPFTVETWFCLMGIILLTAPTLYAIN-------RL 598
            ..:::||.:......:....|: :..::|..|||...|..::...|:.|..::.:.       |.
plant   546 LVDFSQPYASTGLVVVIPANDD-NATWIFLRPFTSRLWCVVLVSFLVIAVVIWILEHRINEDFRG 609

  Fly   599 APLKEMRIVGLSTVKSCFWYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIVLVTTYCGNLVAFL 663
            .|.::     |||:   ..:.|..|.:: ......::..|||:..|..:::||..:|..||.:.|
plant   610 PPRRQ-----LSTM---LLFSFSTLFKR-NQEDTISNLARLVMIVWLFLLMVLTASYTANLTSIL 665

  Fly   664 T---FPKFQPGVDYLNQLEDHKDIVQYGLRNGTFFERYVQSTTREDFKHYLERAKIYGSAQEEDI 725
            |   .|....|:|.|...|     |..|.:.|||...|:      .:...:.|:::......|:.
plant   666 TVQQLPSAITGIDSLRASE-----VPIGYQAGTFTLEYL------TYSLGMARSRLVPLDSTEEY 719

  Fly   726 E-AVKRGERINIDW-----------RINLQLIVQRHFE--REKECH----FALGRES--FVDEQI 770
            | |:|.|.   .:|           .|.|.|..:..|:  .|...|    ||..|:|  .:|...
plant   720 EKALKLGP---TNWGGVAAIVDELPYIELFLAERTGFKIVGEPFMHRGWGFAFKRDSPLAIDMST 781

  Fly   771 AMIVPAQSAYLHLVNRHIKSMFRMGFIERWHQMNLPSAGKCNGKSAQRQVTNHKVNMDDMQGCFL 835
            |::..:::..|..:.:            :|     .....|.|||......| ::::...:|.:|
plant   782 AILKLSETRKLQEIRK------------KW-----LCKTNCAGKSNWNPEPN-QLHLKSFKGLYL 828

  Fly   836 VLLL----GFTLALLIVCGEF-WYRR 856
            |.:.    .|.:.:|.:..:| .|||
plant   829 VCIAITVSAFLVFVLRMIRQFVRYRR 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	58/302 (19%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	59/289 (20%)
GLR5	NP_565744.1	PBP1_GABAb_receptor	32..416	CDD:107361	86/441 (20%)
		ANF_receptor	46..396	CDD:279440	80/413 (19%)
		GluR_Plant	458..800	CDD:270404	77/391 (20%)
		Lig_chan	581..832	CDD:278489	61/291 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010