DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and GLR2

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_001318239.1	Gene:	GLR2 / 816231	AraportID:	AT2G17260	Length:	925	Species:	Arabidopsis thaliana

Alignment Length:	927	Identity:	181/927 - (19%)
Similarity:	325/927 - (35%)	Gaps:	239/927 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LAGLQLSILVPTEANDF--SSFLSANASLAVVVDHEYMTVHG--ENILAHFEKILSDVIRENLRN 75
            |.|.:|.||:    ||.  |.|||...:|. .::.:.:.:.|  .:|:||   :||.:..|
plant    68 LGGSKLRILM----NDAKRSGFLSIMGALQ-FMETDVVAIIGPQTSIMAH---VLSHLANE---- 120

  Fly    76 GGINVKYFSWNAVRLKKDFLAAITVTDCENTWNFYKNTQETSILLI-AITD-------SDCPRLP 132
              :.|...|:          .|:..|.....:.|:..|..:.:.|: ||.:       ||
plant   121 --LTVPMLSF----------TALDPTLSPLQFPFFVQTAPSDLFLMRAIAEMITYYGWSD----- 168

  Fly   133 LNRALMVPIVENGDEFPQLILDAKVQQILNWKTAVVFVDQTILEE------NALLVKSIVHESIT 191
                  |..:.|.|:              |.:..|..:...:.|.      .|:|...:|   ||
plant   169 ------VVALYNDDD--------------NSRNGVTALGDELEERRCKISYKAVLPLDVV---IT 210

  Fly   192 NHITPISLILYEINDSLRGQQKRVALRQALSQFAPKKHEEMRQQFLVISAFHED---IIEIAETL 253
               :|:.:|  |....:||.:.||                     :|::.|...   |.:.||.|
plant   211 ---SPVEII--EELIKIRGMESRV---------------------IVVNTFPNTGKMIFKEAERL 249

  Fly   254 NMFHVG-----NQWMIFVLDM---VARDFDAGTVTINL---DEGANIAFAL---NETDPNCQDSL 304
            .|...|     ..|:..|||.   :......|.:|:.|   |......||.   |:...|....|
plant   250 GMMEKGYVWIATTWLSSVLDSNLPLDTKLVNGVLTLRLHTPDSRKKRDFAARWKNKLSNNKTIGL 314

  Fly   305 NC-------TISEISLA---LVNAISKITVEEESIYGEISDEEWEAIRFTKQEKQAEILEYMKEF 359
            |.       |:..|:.|   |:.|...::...::..|.:..|.......::.::.:::|:|:
plant   315 NVYGLYAYDTVWIIARAVKTLLEAGGNLSFSNDAKLGSLKGEALNLSALSRFDQGSQLLDYI--- 376

  Fly   360 LKTNAKCSSCARWRVETAITWGKSQENRKFRSTPQRDAKNRNFEFIN--------IGYWT----- 411
              .:.|.|...          |..|.:      |.|.....:::.||        ||||:
plant   377 --VHTKMSGLT----------GPVQFH------PDRSMLQPSYDIINLVDDRVHQIGYWSNYSGL 423

  Fly   412 ---PVLGFVCQELAFPHIEHHFRNITMDILTVHNPPWQILTKNS--------------------N 453
               |...|..:.........|..::|....|...|...|...|.                    |
plant   424 SIVPPESFYSKPPNRSSSNQHLNSVTWPGGTSVTPRGWIFRNNGRRLRIGVPDRASFKDFVSRVN 488

  Fly   454 GVIVEHKGIVMEIVKELSRALNFSYYLHEASAWKEEDSLSTSAGGNESDELVGSMTFRIPYRVVE 518
            |...:.:|..:::.:...:.|::. ..||...:  .|.|:..    ..:|||..:|..:.:   :
plant   489 GSSNKVQGYCIDVFEAAVKLLSYP-VPHEFIFF--GDGLTNP----NYNELVNKVTTGVDF---D 543

  Fly   519 MVQGNQFFIAAVAATVEDPDQKPFNYTQP------ISVQKYSFITRKPDEVSRIYLFTAPFTVET 577
            .|.|:   ||.|.......|     :|||      :.|...:.:...|      :.|..|||:..
plant   544 AVVGD---IAIVTKRTRIVD-----FTQPYIESGLVVVAPVTRLNENP------WAFLRPFTLPM 594

  Fly   578 WFCLMGIILLTAPTLYAI-NRLAPLKEMRIVGLSTVKSCFWYIFGALLQQGGMYLPTADS--GRL 639
            |.......::....::.: :|:.  .|.|......:.:..|:.|..:...   :..|..|  ||:
plant   595 WAVTASFFVIVGAAIWILEHRIN--DEFRGPPRRQIITILWFTFSTMFFS---HRETTVSTLGRM 654

  Fly   640 VVGFWWIVVIVLVTTYCGNLVAFLTFPKFQ---PGVDYLNQLEDHKDIVQYGLRNGTFFERYVQS 701
            |:..|..||:::.::|..:|.:.||..:..   .|||.|     .....:.|.:.|:|.|.|:
plant   655 VLLIWLFVVLIITSSYTASLTSILTVQQLNSPIKGVDTL-----ISSTGRIGFQVGSFAENYM-- 712

  Fly   702 TTREDFKHYLERAKIYGSAQEEDIEAVKRGE-RINIDWRINLQLIVQRHFEREKECHFALGRESF 765
               .|..:......:..::.||...|::.|. ...:|.|..:.|.:..:      |.||:..:.|
plant   713 ---TDELNIASSRLVPLASPEEYANALQNGTVAAIVDERPYIDLFLSDY------CKFAIRGQEF 768

  Fly   766 VDEQIAMIVPAQSAYLHLVNRHIKSMFRMGFIERWHQMNLPSAGKCNGKSAQRQVTNHKVNMDDM 830
            .........|..|.....::..|..:...|.:::.|...| |...|:.....:...:.::|:...
plant   769 TRCGWGFAFPRDSPLAVDMSTAILGLSETGELQKIHDRWL-SKSNCSSPHGSQSGDSEQLNVHSF 832

  Fly   831 QGCFLVLLLGFTLALLI 847
            .|.|||:.:...:||.|
plant   833 WGMFLVVGIACLVALFI 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	58/299 (19%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	50/266 (19%)
GLR2	NP_001318239.1	PBP1_GABAb_receptor	35..424	CDD:107361	91/454 (20%)
		GluR_Plant	468..808	CDD:270404	71/384 (18%)
		Lig_chan	594..843	CDD:306551	52/270 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010