DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir93a and grik5

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_001315085.1	Gene:	grik5 / 798791	ZFINID:	ZDB-GENE-070821-6	Length:	1067	Species:	Danio rerio

Alignment Length:	973	Identity:	193/973 - (19%)
Similarity:	355/973 - (36%)	Gaps:	265/973 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLAGLQLSILVPTEANDFSSFLS-----ANASLAVVVDHEYMTVHGENILAHFEKILSDVIRENL 73
            ||..:....|:.|......|.||     ::..:|.::|...:...||.:.....:...:.:.||.
Zfish     7 LLLSIYFRFLLVTVVTMPPSSLSQTPVLSSVRMAAILDDSSVCGRGERLALALARENINSVMENP 71

  Fly    74 RNGGINVKYFSWNAVRLKKDFLAAITVTDCE----------------NTWNFYKN-TQETSILLI 121
            ....:.|..|     .|:||.....|.|.|:                .:.:...: ..|..|..:
Zfish    72 ARARVEVDIF-----ELQKDSQYETTDTMCQILPKGVVSVIGPASSPASGSIVSHICGEKEIPHV 131

  Fly   122 AITDSDCPRLPLNRALMVPIVENGDE-------------FPQL-ILDAKVQQILNWKTAVVFVDQ 172
            .|...:.||||..|...|.:..:.::             :|.. ::.||.:.:|..:.   .:.:
Zfish   132 KIGPEETPRLPYLRFASVTLYPSNEDLSLAIGSILRSFSYPSASLVCAKAECLLRLEE---LIRR 193

  Fly   173 TILEENALLVKSIVHESITNHITPISLILYEINDSLRGQQKRVA-----LRQALSQFAPKKHEEM 232
            .::....|.::     .:.:::.|..| |.||.|.      ::|     ...::|....||..|:
Zfish   194 FLISRETLSIR-----MLDDNLDPTPL-LKEIRDD------KIATIIIDANASISYLILKKASEL 246

  Fly   233 RQQFLVISAFH--------------EDIIEIAETLNMFHVGNQWMIFVLDMV------------- 270
            .    :.|||:              :||::....:..|.:.|....|.|:.:
Zfish   247 G----MTSAFYKYILTTMDFPLLWLDDIVDEQSNIVGFSMFNTTHPFYLEFIRSLNLSWREGCDI 307

  Fly   271 ----------ARDFDAGTVTINLDEGANIAFALNETDPNCQDSLNCTISEI---SLALVNAISKI 322
                      |..|||..|.::..:      .||.:.......|:||..:|   ..:|:|.:.
Zfish   308 NPYPGPALSSALLFDAVHVVVSAVQ------ELNRSQEIGVKPLSCTSPQIWQHGTSLMNYLR-- 364

  Fly   323 TVEEESIYGEISDEEWEAIRFTKQEKQAEILEYMKEFLKTNAKCSSCARWRVETAITWGKSQENR 387
            .||.:.:.|.:                    |:..:..:||.......:.|       |..:|
Zfish   365 MVEYDGLTGRV--------------------EFNSKGQRTNYTLHILEKHR-------GGHKE-- 400

  Fly   388 KFRSTPQRDAKNRNFEFINIGYW----TPVLGFVCQELAFPHIEHHFRNITMDILTVHNPPWQIL 448
                               ||.|    |.::.....::   ::.....|.::.|.|:...|:.:.
Zfish   401 -------------------IGIWYSNNTLLMNSTSLDI---NVSETLANKSLIITTILENPYVMR 443

  Fly   449 TKN-----SNGVIVEHKGIVMEIVKELSRALNFSYYLHEASAWKEEDSLSTSAGGNES-DELVGS 507
            ..|     .|   .:::|..:::::|||..|.|:|.:...     :|.|..:...|.| ..:||.
Zfish   444 KINYQEFEGN---EQYEGFCVDMLRELSDILKFTYRIKLV-----DDGLYGAPEPNGSWTGMVGE 500

  Fly   508 MTFRIPYRVVEMVQGNQFFIAAVAATVEDPDQKPFNYTQP-----ISVQKYSFITRKPDEVSRIY 567
            :..|            :..:|..|.|:....:|..::::|     ||:.....|.|||...|
Zfish   501 LINR------------KADLAVAAFTITSEREKVIDFSKPFMTLGISILYRVHIGRKPGYFS--- 550

  Fly   568 LFTAPFTVETWFCLMGIILLTAPTLYAINRLAP---------LKEMR--IVGLSTVKSCFWYIFG 621
             |..||:...|..::...|..:..|:...||:|         |:|.|  :....|:.:..|:..|
Zfish   551 -FLDPFSPAVWLFMLLAYLAVSCVLFLSARLSPYEWYNPHPCLRERRDLLENQYTLGNSLWFPVG 614

  Fly   622 ALLQQGGMYLPTADSGRLVVGFWWIVVIVLVTTYCGNLVAFLTFPKFQPGVDYLNQLEDHKDIVQ 686
            ..:|||...:|.|.|.|.|.|.||...::::::|..||.||||..:.:..::..:.|.|..:| |
Zfish   615 GFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESPDDLADQTNI-Q 678

  Fly   687 YGLRNG----TFF--ERYVQSTTREDFKHYLERAKIYGSAQEEDIEAVKRGERINIDWRINLQLI 745
            ||..:|    |||  .|| |:..|.....|.::..::..:.||.|..|     :|..:...|: .
Zfish   679 YGTIHGGSTMTFFMNSRY-QTYQRMWNYMYSKQPSVFVKSTEEGIARV-----VNSKYAFLLE-S 736

  Fly   746 VQRHFEREKECH------------FALGR---ESFVDE-QIAMIVPAQSAYLHLVNRHIKSMFRM 794
            ....:.|...|:            :.:|.   ..|.|| .:|::...::..|.::.|
Zfish   737 TMNEYHRSLNCNLTQIGGLLDTKGYGIGMPLGSPFRDELSLAVLQLQENNRLEILKR-------- 793

  Fly   795 GFIERWHQMNLPSAGKCNGKSAQRQVTNHKVNMDDMQGCFLVLLLGFTLALLIVCGEF-WYRR 856
                ||.:     .|||..:...|.   ..:.|:::.|.|:||:.|..:|:.:...|| |..|
Zfish   794 ----RWWE-----GGKCPKEEDHRA---KGLGMENIGGIFVVLICGLIIAVFVAVMEFVWSTR 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	75/295 (25%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	69/292 (24%)
grik5	NP_001315085.1	PBP1_iGluR_Kainate_KA1_2	38..412	CDD:107389	74/453 (16%)
		ANF_receptor	55..392	CDD:279440	63/388 (16%)
		Periplasmic_Binding_Protein_Type_1	<313..383	CDD:299141	17/97 (18%)
		Periplasmic_Binding_Protein_Type_2	427..797	CDD:304360	97/413 (23%)
		Lig_chan	558..828	CDD:278489	71/297 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591395
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840