DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir93a and gria1a

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_991161.1	Gene:	gria1a / 798689	ZFINID:	ZDB-GENE-020125-1	Length:	914	Species:	Danio rerio

Alignment Length:	958	Identity:	176/958 - (18%)
Similarity:	353/958 - (36%)	Gaps:	222/958 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 AGLQLSILVPTEANDFSSF---LSANASLAVVVDHEYMTVHGEN------ILAHFEKILSDVIRE 71
            :.:.:..|.|||::::..|   ||.:..:..:|....|...|.:      ..:.|.|.:..:|
Zfish    23 SNINIGGLFPTESHEYEVFRFALSHHQDIPKLVPQVDMVKLGNSFSMTYAFCSQFSKGVYAII-- 85

  Fly    72 NLRNGGINVKYFSWNAVRLKKDFLAAITVTDCENTWNF-YKNTQETSILLIAITDSDCPRLPLNR 135
                 |:    :....|.:...|..|:.|  |..|.:| .:|:.:..|.|         |..|..
Zfish    86 -----GV----YDRKTVNMLMSFCGALHV--CFVTPSFPMENSNQFVIQL---------RPELQD 130

  Fly   136 ALMVPIVE--------------NGDEFPQLILDAKVQQILNWKTAVVFVDQTILEENALLVKSIV 186
            || |.::|              :|....|.:||...:.  ||                 ||.|:.
Zfish   131 AL-VGVIEHYRWSKFVYMYSSDSGLSVLQKVLDTAAEH--NW-----------------LVTSVN 175

  Fly   187 HESITNHITPISLILYEINDSLRGQQKRVALRQALSQFAPKKHEEMRQQFLVISAFHEDIIEIAE 251
            .|::|.     :..|....|..:.::.::.:...|.:               :::..:.|||:.:
Zfish   176 VETMTE-----ASFLKVFQDLDKKKEGQIIIDCELER---------------LTSILKKIIELGK 220

  Fly   252 TLNMFH--VGNQWMIFVLDMVARDFDAGTVTINLDEGANIAFAL-NETDPNCQDSLNCTISEISL 313
            .:..:|  :.|   :..||:...:|..|...:.       .|.| |..|||    ::.|:.: .:
Zfish   221 NVKSYHYILAN---LGFLDIDLTEFKKGEANVT-------GFQLVNYADPN----VSRTVQQ-WM 270

  Fly   314 ALVNAISKITVEEESIYGEISDEEWEAIRFTKQEKQAEILEYMKEFLKTNAKCSSCARW------ 372
            ...|..:|:........|.::.:..:.:....|..:.:.::..:.........:..|.|
Zfish   271 EFDNKDAKVPKRRLKYTGALTYDGVKVMSTAFQNLRRQRIDISRRGNAGECLANPPAPWGQGIDI 335

  Fly   373 -------RVETAITWGKSQENRKFRSTPQRDAKNRNFEFI--------NIGYWTPVLGFVCQELA 422
                   |:| .:| |..|.|.|.|.|      |.:...:        .:|||.....||.....
Zfish   336 QRALQQVRIE-GLT-GHIQFNEKGRRT------NYSISVMELRPTGPKKVGYWNEDEKFVSTAAY 392

  Fly   423 FP--HIEHHFRNITMDILTVHNPPWQILTKNSNGVIVEH-------KGIVMEIVKELSRALNFSY 478
            .|  :..:..:|.|..:.|:...|:.:|.||.     ||       :|..:|:..|:::.:.:.|
Zfish   393 MPGSNETYGLQNRTYIVTTILESPYVMLKKNH-----EHFTGNDKYEGYCVELAAEIAKHVGYHY 452

  Fly   479 YLHEASAWKEEDSLSTSAGGNESDELVGSMTFRIPYRVVEMVQGNQFFIAAVAATVEDPDQKPFN 543
            .|...:..|        .|..:::.::.:      ..|.|:|.| :..:|....|:....::..:
Zfish   453 ILKIVADGK--------YGARDAETMMWN------GMVGELVYG-KADVAVAPLTITLVREEVID 502

  Fly   544 YTQPISVQKYSFITRKPDEVS-RIYLFTAPFTVETWFCLMGIILLTAPTLYAINRLAPL------ 601
            :::|......|.:.:||.:.. .::.|..|...|.|.|::...:..:..|:.::|.:|.
Zfish   503 FSKPFMSLGISIMIKKPTKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHADD 567

  Fly   602 -------------------------------KEMRIVGLSTVKSCFWYIFGALLQQGGMYLPTAD 635
                                           ::....|   :.:..|:..||.:|||....|.:.
Zfish   568 CEDGAEENPNQPSSSSAQPGQNQQNQNQQSQEQTNEFG---IFNSLWFSLGAFMQQGCDISPRSL 629

  Fly   636 SGRLVVGFWWIVVIVLVTTYCGNLVAFLTFPKFQPGVDYLNQLEDHKDIVQYGLRNGT---FFER 697
            |||:|.|.||...::::::|..||.||||..:....::....|....:|....|..|:   ||.|
Zfish   630 SGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDAGSTKEFFRR 694

  Fly   698 YVQSTTREDFKHYLERA--KIYGSAQEEDIEAVKRGERINIDWRINLQLIVQRHFEREKECHFAL 760
             .:....|....|::.|  .::....:|.:..|::.:.   .:...|:..:..:.|:.|.|....
Zfish   695 -SKIAVFEKMWSYMKSADPSVFVKTTDEGVMRVRKSKG---KYAYLLESTMNEYIEQRKPCDTMK 755

  Fly   761 GRESFVDEQIAMIVPAQSAYLHLVNRHIKSMFRMGFIER-----WHQMNLPSAGKCNGKSAQRQV 820
            ...:...:...:..|..|...:.||..:..:...|.:::     |:     ..|:|.......:.
Zfish   756 VGGNLDSKGYGIATPKGSPLRNPVNLAVLKLNEQGLLDKLKNKWWY-----DKGECGSGGGDSKD 815

  Fly   821 TNHKVNMDDMQGCFLVLLLGFTLALLIVCGEFWYRRFRASRKRRQFTN 868
            ....:::.::.|.|.:|:.|..||:|:...||.|:....||:.:|..|
Zfish   816 KTSALSLSNVAGVFYILIGGLGLAMLVALVEFCYKSRTESRRMKQSIN 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	62/315 (20%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	54/306 (18%)
gria1a	NP_991161.1	Periplasmic_Binding_Protein_Type_1	26..387	CDD:299141	79/445 (18%)
		ANF_receptor	36..369	CDD:279440	72/417 (17%)
		PBP2_iGluR_AMPA_GluR1	404..806	CDD:270447	79/433 (18%)
		Lig_chan	536..836	CDD:278489	55/311 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591357
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.940