DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir93a and grik1a

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	XP_009303592.1	Gene:	grik1a / 798001	ZFINID:	ZDB-GENE-030131-6502	Length:	919	Species:	Danio rerio

Alignment Length:	826	Identity:	165/826 - (19%)
Similarity:	314/826 - (38%)	Gaps:	205/826 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 PIVENGDEF-----------PQLILDAKVQQILNWK-TAVVFVDQTILEENALLVKSIVHESITN 192
            |.|:|.|.|           .:.|||..:  ...|| ..||:.|.|.|.....|:|:....::..
Zfish   140 PSVDNKDNFYINLYPEYTSISRAILDIVI--FYKWKCVTVVYEDSTGLMRMQELIKAPSKNNLKI 202

  Fly   193 HITPISLILYEINDSLRGQQKRVALRQALSQFAPKKHEEMRQQFLVISAFHEDIIEIAETLNMFH 257
            .|..:         ...|...|..|::.      ||.:|.   :::....::...|:.:.|....
Zfish   203 RIRQL---------PSGGGDSRPLLKEM------KKEKEF---YVIFDCSYQVAAELLKQLMSMG 249

  Fly   258 VGNQWM--------IFVLDMVARDFDAGTVT----INLDEGANIAFALNE-------TDPNCQDS 303
            :..::.        :|.||:....:....:|    :|||: :.:|..:.:       ..|..:..
Zfish   250 MMTEYYHFFFTTLDLFALDLEPYRYSGVNMTAFRLLNLDD-SYVASVIQKWSMERQLAPPKPESG 313

  Fly   304 LNCTISEISLALV-NAISKITVEEESIYGEISDEEWEAIRFTKQEKQA----------EILEYMK 357
            |...|...:.||: :|:..:.|..:           .|.:.|....|.          ..:...|
Zfish   314 LMSGIMTTAAALMYDAVFMVAVASQ-----------RATQMTVSSLQCHRHKPWRYGPRFMNLFK 367

  Fly   358 EFLKTNAKCSSCARW-----RVETAITWGKSQE------NRKFRSTPQR--DAKNR-NFEFINIG 408
            |           |:|     |:....|.|..:|      :.|...|.:|  |..:| |..:..||
Zfish   368 E-----------AQWDGLTGRIVLNKTDGLRKEFNLDLISLKEDGTAKRVADGASRPNKLWTKIG 421

  Fly   409 YWTPVLGFVCQELA-FPHIEHHFRNITMDILTVHNPPWQILTKNSNGVIV---EHKGIVMEIVKE 469
            .|....|....|:. ..:|.....|.|:.:.|:...|: ::.|.|:.|:.   ..:|..::::||
Zfish   422 VWNSYTGLNLTEIKDNKNITDSLANRTLIVTTILENPY-VMYKKSDKVLYGNDRFEGYCLDLLKE 485

  Fly   470 LSRALNFSYYLHEASAWKEEDSLSTS---AGGNESDELVGSMTFRIPYRVVEMVQGNQFFIAAVA 531
            ||..|.|:|          |..|.|.   ...|:..|..|.:.     .:::.:..    :|...
Zfish   486 LSNILGFTY----------EVKLVTDGKYGAQNDKGEWNGMVR-----ELIDHIAD----LAVAP 531

  Fly   532 ATVEDPDQKPFNYTQPISVQKYSFITRKPDEVS-RIYLFTAPFTVETWFCLMGIILLTAPTLYAI 595
            .|:....:|..::::|......|.:.|||:..: .::.|..|.|.:.|..::...|..:..|:.|
Zfish   532 LTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLTPDIWMYVLLACLGVSCVLFVI 596

  Fly   596 NRLAPLK---------EMRIVGLS-TVKSCFWYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIV 650
            .|..|.:         ...:|..: |:.:..|:...||::||...:|.|.|.|::.|.||...::
Zfish   597 ARFTPYEWYNPHPCNPSSEVVENNFTLLNSLWFGVAALMRQGSELMPKALSTRILGGIWWFFTLI 661

  Fly   651 LVTTYCGNLVAFLTFPKFQPGVDYLNQLEDHKDIVQYG-LRNG---TFFERYVQSTTREDFKHYL 711
            ::::|..||.||||..:....:|..:.|.....| :|| :|:|   |||::...||        .
Zfish   662 IISSYTANLAAFLTVERMDSPIDSADDLAKQTRI-EYGAVRDGSTMTFFKKSKIST--------Y 717

  Fly   712 ERAKIYGSAQEED--IEAVKRG--ERINIDWRI-----NLQLIVQRHFEREKECHFA-LGRESFV 766
            |:...:.|:::..  ::..|.|  ..:..|:.:     :::.|.||:      |:.. :|  ..:
Zfish   718 EKMWAFMSSRKNTALVKNSKDGITRVLTTDYALLMESTSIEYITQRN------CNLTQVG--GLI 774

  Fly   767 DEQ-----------------IAMIVPAQSAYLHLVNRHIKSMFRMGFIERWHQMNLPSAGKCNGK 814
            |.:                 ||::...:...||::.            |:|        .:.||.
Zfish   775 DSKGYGVGTPIGSPYRDKVTIAILQLQEEGKLHMMK------------EKW--------WRGNGC 819

  Fly   815 SAQRQVTNHKVNMDDMQGCFLVLLLGFTLALLIVCGEFWYRRFRAS 860
            ..:.......:.::::.|.|:||..|..|::.:..|||.|:..:.|
Zfish   820 PEEDSKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSHKNS 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	69/288 (24%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	60/300 (20%)
grik1a	XP_009303592.1	Periplasmic_Binding_Protein_Type_1	37..432	CDD:299141	62/334 (19%)
		ANF_receptor	57..398	CDD:279440	52/300 (17%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:304360	88/425 (21%)
		Lig_chan	577..846	CDD:278489	62/305 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591364
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840