DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and grid1a

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	XP_021323097.1	Gene:	grid1a / 793756	ZFINID:	ZDB-GENE-120411-28	Length:	1044	Species:	Danio rerio

Alignment Length:	937	Identity:	170/937 - (18%)
Similarity:	324/937 - (34%)	Gaps:	259/937 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 FSWNAVR-------------LKKDFLAAITVTDC-----ENTWNFYKNTQETSIL-----LIAIT 124
            |..||:|             |..|.|.:..:|..     .|  |.::..||...|     |..::
Zfish    30 FEQNAIRDDEVFQLAISDLSLNDDILQSERITHSIKLIEPN--NPFQAVQEACELMNQGILALVS 92

  Fly   125 DSDCPRL----PLNRALMVP---IVENGDEFPQL----------------------ILDAKVQQI 160
            .:.|...    .|..|:.:|   |..|||..|:.                      :.|..:..:
Zfish    93 STGCAAANALQSLTDAMHIPHLFIQRNGDGTPRAECQLNPSPDGERYTLAARPPVRLNDVMITLV 157

  Fly   161 --LNWKTAVVFVD--------QTILEENALLVKSIVHESITNHITPISLILY------EINDSLR 209
              |.|...:||.|        :..|::.:.:...:..:.:..::|.:...|:      |:|
Zfish   158 SELRWHKFIVFYDSEYDVRGLRGFLDQASRMGLDVSLQQVDRNVTKVFSTLFSTMRMEELN---- 218

  Fly   210 GQQKRVALRQALSQFAPKKHEEMRQQFLVISAFHEDI--------IEIAETLNMFH--VGNQWMI 264
              :.|..||:|:...:|:..:....|.:..:...:|.        :...|.:.:.|  :|...:|
Zfish   219 --RYRDTLRRAILLLSPRTAQVFIHQAVETNLASKDSHWVYANEEVSDTEIMELVHSALGRMTVI 281

  Fly   265 FVLDMVARDFDAGTVTINLDEGANIAFALNE-------TDPNCQDSLNCTISEISLALVNAISKI 322
            ..:..:.||             .||....|.       .||  |:....::...||.|.:::..:
Zfish   282 RQIFPLWRD-------------TNIRCMRNNHRISSLLCDP--QEGYLQSLEVSSLYLYDSVLML 331

  Fly   323 TVEEESIYGEISDEEWEAI-------RFTK--------------------------------QEK 348
            .   .:.|.::.|.:|.::       :.||                                ...
Zfish   332 A---NAFYRKLEDRKWHSMASLNCMRKSTKPWNGGWSMLDTIQKGRISGLTGLMDFRSNGANSHV 393

  Fly   349 QAEIL--EYMKEFLKTNAKCSSCARWRVETAITW-------GKSQENRKFRSTPQRDAKNRNFEF 404
            |.|||  .|.:.|.|.           |:...||       |..:|||
Zfish   394 QFEILGTSYSETFGKD-----------VKRLATWDSDRGLNGSLRENR----------------- 430

  Fly   405 INIGYWTPVLGFVCQELAFPHIEHHFRNITMDILTVHNPPWQILTKNSNGVIVEHKGIVMEIVKE 469
                                 .:|..:.||:.::|:...|:.::.:|..|....:||..::::..
Zfish   431 ---------------------ADHGMQGITLKVVTLLEEPFVMVAENILGQPKRYKGFSIDVLDA 474

  Fly   470 LSRALNFSYYLHEASAWKEEDSLSTSAGGNESDELVGSMTFRIPYRVVEMVQGNQFFIAAVAATV 534
            |::.|.|.|.:::.:..|.....:..:......||:|...              ...|:|:..|.
Zfish   475 LAKILGFKYEMYQVADAKYGSPQTNGSWNGMIGELIGKRA--------------DVAISAITITP 525

  Fly   535 E-----DPDQKPFNYTQPISVQKYSFITRKPDEVSRIYLFTAPFTVETWFCLMGIILLTAPTLYA 594
            |     |..::..:|:..|       :..|.:|...|:...|||.:..|.|:...|.:....::.
Zfish   526 ERENVVDFSKRYLDYSVGI-------LMTKTEERLNIFSLLAPFDLAVWACIAAAIPVVGVMVFL 583

  Fly   595 INRLAPLKEMRIVG-------LSTVKSCFWYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIVLV 652
            :.|:..::.....|       .::.:|..|.::||.:||||....::.:.|:.:|.||:..:::.
Zfish   584 LRRVQSVRSQNPPGPHQPASVTTSFQSAIWIVYGAFVQQGGESFMSSMALRIAMGSWWLFTLIVC 648

  Fly   653 TTYCGNLVAFLTFPKFQPGVDYLNQLEDHKDIVQYG-LRNGTFFERY-VQSTT-REDFKHYLERA 714
            ::|..||.|:||..:....:.....|....:| .|| :|....||.: |:.|. .|....:.|..
Zfish   649 SSYTANLAAYLTVSRMDNAIRTFQDLSKQSEI-NYGTVRESAVFEYFRVKGTNPLEQDSTFAELW 712

  Fly   715 KIYGSAQEED---------IEAVKRGERINIDWRINLQLIVQRHFEREKECHFALGRESFVDEQI 770
            :.....|.:|         |..|||.....: |.:   .:::.....:.:|...:.......:..
Zfish   713 RTINKNQGQDNSVTSPAEGIRKVKRDPYAFL-WDM---AVLEYAALTDDDCTLVVTGNGMSSKGY 773

  Fly   771 AMIVPAQSAYLHLVNRHIKSMFRMGFIERWHQMNLPSAGKCN-GKSAQRQVTNHKVNMDDMQGCF 834
            .:.:...|.|..|.::.|..:...|.::...|...|..|:|: .|.|:.|.....:.:....|.|
Zfish   774 GLALQHGSPYRDLFSQKILDLQEKGDLDILKQKWWPRKGRCDLDKHAEPQTEGRALRLHSFAGVF 838

  Fly   835 LVLLLGFTLALLIVCGEFWYRRFRASR 861
            .:|..|..||.|:...|.|:...|..|
Zfish   839 CILAAGLLLACLVAALESWWNGPRCQR 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	58/280 (21%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	56/279 (20%)
grid1a	XP_021323097.1	Periplasmic_Binding_Protein_Type_1	25..424	CDD:324556	71/430 (17%)
		PBP2_iGluR_delta_1	437..809	CDD:270448	77/397 (19%)
		DNA_pol3_gamma3	<915..1044	CDD:331207
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591119
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840