DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and grik1b

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	XP_690040.5	Gene:	grik1b / 561540	ZFINID:	ZDB-GENE-070821-1	Length:	906	Species:	Danio rerio

Alignment Length:	934	Identity:	191/934 - (20%)
Similarity:	336/934 - (35%)	Gaps:	254/934 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 IRENLRNGGINVKYFSWNAVRLKKDFLAAITVTDCENTWNFYKNTQET-SILLIAITDS------ 126
            |.|.|.|..|:|:..::.           ..||:.........||..| .|..|.:.||
Zfish    69 IFETLENEPISVEELAFK-----------FAVTNINRNRTLMPNTTLTYDIQRINLFDSFEASRR 122

  Fly   127 DCPRLPLN--------------------RALMV---------PIVENGDEF-----------PQL 151
            .|.:|.|.                    .||.|         |.|:|.|.|           .:.
Zfish   123 ACDQLALGVAAVFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDSFYINLYPDYASISRA 187

  Fly   152 ILDAKVQQILNWK-TAVVFVDQTILEENALLVKSIVHESITNHITPISLILYEINDSLRGQQKRV 215
            :||  :.|...|| ..||:.|.|.|.....|:|:....||                       ::
Zfish   188 VLD--IVQFYKWKAVTVVYEDATGLIRLQELIKAPSRYSI-----------------------KI 227

  Fly   216 ALRQ--ALSQFAPKKHEEMR--QQFLVI--SAFH--EDIIEIAETLNMFHVGNQWMIFVLDMVAR 272
            .:||  ..|:.|....:||:  ::|.||  .::.  .|:::...::.|......:....||:.:.
Zfish   228 KIRQLPTGSKDARPLLKEMKKGKEFCVIFDCSYQTAADVLKQLLSMGMMTEYYHFFFTTLDLYSL 292

  Fly   273 DFD---------AGTVTINLDEGANIAFALN-----------ETDPNCQDSLNCTISEISLALVN 317
            |.:         .|...:|:| ...:|..:.           :.:...||.:..|.:.:....|.
Zfish   293 DLEPFRYSGVNMTGFRLLNID-NPQVASVVEKWSMERLQAPPKPETGLQDGMMTTEAALMYDAVY 356

  Fly   318 AI-------SKITVEEESIYGEISDEEWE-AIRFTKQEKQAEILEYMKEFLKTNAKCSSCARWRV 374
            .:       |:|||.....:   ..:.|. ..||....|:|:                    |..
Zfish   357 MVAAASQRASQITVSSLQCH---RHKPWRFGSRFISMFKEAQ--------------------WNG 398

  Fly   375 ETA-ITWGKSQENRKFRSTPQRDAKNRNFE-----------FINIGYWTPVLGF----------- 416
            .|. |...|:...||.........|....|           :..||.|....|.
Zfish   399 LTGQIIINKTDGLRKDFDLDIISLKEDGLEKPLESGRFNKVWKKIGVWNSNTGLNLTDSNKDKNT 463

  Fly   417 -VCQELAFPHIEHHFRNITMDILTVHNPPWQILTKNSNGVIV---EHKGIVMEIVKELSRALNFS 477
             |...:|         |.|:.:.|:...|: ::.|.|:..:.   ..:|..::::||||..|.||
Zfish   464 NVTDSMA---------NRTLIVTTILENPY-VMYKKSDKPLYGNDRFEGYCLDLLKELSNILGFS 518

  Fly   478 YYLHEASAWKEEDSLSTS---AGGNESDELVGSMTFRIPYRVVEMVQGNQFFIAAVAATVEDPDQ 539
            |          |..|.|.   ...|:..|..|.:.     .:::.|..    :|....|:....:
Zfish   519 Y----------EVKLVTDGKYGAQNDKGEWNGMVR-----ELIDHVAD----LAVAPLTITYVRE 564

  Fly   540 KPFNYTQPISVQKYSFITRKPDEVS-RIYLFTAPFTVETWFCLMGIILLTAPTLYAINRLAPLK- 602
            |..::::|......|.:..||:..: .::.|..|.:.:.|..::...|..:..|:.|.|..|.:
Zfish   565 KVIDFSKPFMTLGISILYHKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEW 629

  Fly   603 --------EMRIVGLS-TVKSCFWYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIVLVTTYCGN 658
                    :..:|..: |:.:..|:..|||:|||...:|.|.|.|:|.|.||...::::::|..|
Zfish   630 YNPHPCNPDSDVVENNFTLINSVWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTAN 694

  Fly   659 LVAFLTFPKFQPGVDYLNQLEDHKDIVQYG-LRNG---TFFERYVQSTTREDFKHYLERAKIYGS 719
            |.||||..:....:|..:.|.....| :|| :|:|   |||::...||..:.:.....|...  :
Zfish   695 LAAFLTVERMDSPIDSADDLAKQTKI-EYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRKNT--A 756

  Fly   720 AQEEDIEAVKRGERINIDWRI-----NLQLIVQRHFEREKECHFA-LGRESFVDEQ-IAMIVPAQ 777
            ..:.:.|.::|  .:..|:.:     :::.|.||:      |:.. :|  ..:|.: ..:..|..
Zfish   757 LVKNNREGIQR--VLTTDYALLMESTSIEYISQRN------CNLTQIG--GLIDSKGYGVGTPIG 811

  Fly   778 SAYLHLVNRHIKSMFRMGFI----ERWHQMNLPSAGKCNGKSAQRQVTNHKVNMDDMQGCFLVLL 838
            |.|...|...|..:...|.:    |:|        .:.||...:.......:.::::.|.|:||.
Zfish   812 SPYRDKVTIAILQLQEEGKLHMMKEKW--------WRGNGCPEEDSKEASALGVENIGGIFIVLA 868

  Fly   839 LGFTLALLIVCGEFWYRRFRASRK 862
            .|..|::.:..|||.|:    |||
Zfish   869 AGLVLSVFVAIGEFIYK----SRK 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	71/288 (25%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	64/284 (23%)
grik1b	XP_690040.5	Periplasmic_Binding_Protein_Type_1	62..455	CDD:299141	83/445 (19%)
		ANF_receptor	80..423	CDD:279440	72/402 (18%)
		Periplasmic_Binding_Protein_Type_2	471..840	CDD:304360	91/409 (22%)
		Lig_chan	602..871	CDD:278489	66/289 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591363
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840