DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and grin2bb

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_001121809.1	Gene:	grin2bb / 559976	ZFINID:	ZDB-GENE-061207-27	Length:	1770	Species:	Danio rerio

Alignment Length:	915	Identity:	163/915 - (17%)
Similarity:	327/915 - (35%)	Gaps:	259/915 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 KNTQETSILLIAITDS------------DCPRLPLNRALMVPIVENGDEFPQLILDAKVQQIL-- 161
            |..|..||.:|.:.:|            |...:||  ...|.:|...:..|:.|:: ::..::
Zfish   104 KFAQGLSIAVILVGNSSEVSLSEGLEKEDFLHVPL--PPKVELVTMNETDPKSIIN-RICALMSR 165

  Fly   162 NWKTAVVFVDQT----------------------------------------------------- 173
            ||...|||.|.|
Zfish   166 NWLQGVVFGDDTDQEAIAQILDFISAQTHIPILGIRGGSSMIMAAKDDHSMFFQFGPSIEQQASV 230

  Fly   174 ---ILEENALLVKSIV------HESITNHITPI---SLILYEINDSLRGQQKRVALRQALSQFAP 226
               |:||....:.|||      |:...|.|...   |.:.:|:.:.|       .|..::.....
Zfish   231 MLNIMEEYDWYIFSIVTTYYPGHQDFVNRIRSTVDNSFVGWELEEVL-------LLDMSVDDGDS 288

  Fly   227 KKHEEMRQ---QFLVISAFHED---IIEIAETLNMFHVGNQWMIFVL-----DMVARDFDAGTVT 280
            |...:|::   ..:::....|:   |.|:|.::.:...|..|::..|     |.|...|..|.::
Zfish   289 KIQNQMKKLQSPVILLYCTKEEATTIFEVAHSVGLTGYGYTWIVPSLVAGDTDNVPNVFPTGLIS 353

  Fly   281 INLDEG------------ANIAFALN----------------ETDPNCQDSLNCTISEISLALVN 317
            ::.||.            |.||.|.:                ...|:.:.|.:...:|:...|:|
Zfish   354 VSYDEWDYGLEARVRDAVAIIAMATSTMMLDRGPHTLLKSGCHGAPDKKGSKSGNPNEVLRYLMN 418

  Fly   318 AISKITVEEESIYGEISDEEWE-----AIRFTKQEKQAEILEYMKEFLKTNAKCSSCARWRVETA 377
                :|.|..::  ..|::.::     .|....:|:|.|                     ||.
Zfish   419 ----VTFEGRNL--SFSEDGFQMHPKLVIILLNKERQYE---------------------RVG-- 454

  Fly   378 ITWGKSQENRKFRSTPQ----RDAKNRNFE-----------FINIGYWTPVLGFVCQELAFP-HI 426
             .|.......|:...|:    .||:.|..:           |:.:....|:.| .|.....| ..
Zfish   455 -KWENGSLAMKYHVWPRFELYSDAEEREDDHLSIVTLEEAPFVIVEDVDPLSG-TCMRNTVPCRK 517

  Fly   427 EHHFRNITMDILTVHNPPWQILTKNSNGVIVEH--KGIVMEIVKELSRALNFSYYLHEASAWKEE 489
            :...:|:|.|                :|:.::.  ||..::|:|::::::.|:|.|:..:..|..
Zfish   518 QLKLQNLTGD----------------SGIYIKRCCKGFCIDILKKIAKSVKFTYDLYLVTNGKHG 566

  Fly   490 DSLSTSAGGNESDELVGSMTFRIPYRVVEMVQGNQFFIAAVAATVEDPDQKPFNYTQP-----IS 549
            ..::.:..|     :||.:..:..:            :|..:.|:.:...:..:::.|     ||
Zfish   567 KKINGTWNG-----MVGEVVLKNAH------------MAVGSLTINEERSEVIDFSVPFIETGIS 614

  Fly   550 VQKYSFITRKPDEVSRIYLFTAPFTVETWFCLMGIILL-TAPTLYAINRLAPLKEMRIV------ 607
            |    .::|....||. ..|..||:.:.|..:..::|: :|..::.....:|:...|.:
Zfish   615 V----MVSRSNGTVSP-SAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREP 674

  Fly   608 -GLS-TVKSCFWYIFGALLQQG-GMYLPTADSGRLVVGFWWIVVIVLVTTYCGNLVAFLTFPKFQ 669
             |.| |:....|.::|.:.... .:..|...:.:::|..|....::.:.:|..||.||:...::
Zfish   675 GGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEY- 738

  Fly   670 PGVDYLNQLED----HKDIVQYGLRNGTFFERYVQSTTREDFKH---YLERAKIYGSAQEEDIEA 727
              ||.:..|.|    |.:......|.||......:...|.::|.   |:  ...:.....|.:.:
Zfish   739 --VDQVTGLSDKKFQHPNDFSPPFRFGTVPNGSTERNIRNNYKEMHSYM--TSFHQKNVNEALHS 799

  Fly   728 VKRGERINIDWRINLQLIVQRHFEREKECHF-ALGR-ESFVDEQIAMIVPAQSAYLHLVNRHIKS 790
            :|.|:   :|..|....::.....|::.|.. .:|. ..|......:.:...|.:...|:..|..
Zfish   800 LKSGK---LDAFIYDAAVLNYMAGRDEGCKLVTIGSGYIFATTGYGIAIQKDSGWKRAVDLAILQ 861

  Fly   791 MFRMGFIERWHQMNLPSAGKCNGKSAQRQVTNHKVNMDDMQGCFLVLLLGFTLALLIVCGE---F 852
            :|..|.:|....:.|  .|.|:.:  :.:|.:.::::|:|.|.|.:|.....|:|:....|   :
Zfish   862 LFGDGEMEELEALWL--TGICHNE--KNEVMSSQLDVDNMAGVFYMLGAAMALSLITFIAEHLFY 922

  Fly   853 WYRRF 857
            |..||
Zfish   923 WQLRF 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	53/288 (18%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	52/278 (19%)
grin2bb	NP_001121809.1	PBP1_iGluR_NMDA_NR2	107..470	CDD:107373	67/402 (17%)
		ANF_receptor	138..442	CDD:279440	52/319 (16%)
		PBP2_iGluR_NMDA_Nr2	482..882	CDD:270436	79/448 (18%)
		Lig_chan	636..908	CDD:278489	53/283 (19%)
		NMDAR2_C	919..1770	CDD:287527	3/9 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591349
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840