DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir93a and grid1b

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	XP_009304811.1	Gene:	grid1b / 557511	ZFINID:	ZDB-GENE-121214-84	Length:	1048	Species:	Danio rerio

Alignment Length:	878	Identity:	165/878 - (18%)
Similarity:	336/878 - (38%)	Gaps:	166/878 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 NVKYFSWN----AVR-----LKKDFLAAITVTDCENTWNFYKNTQETSILLIAITDS-DCPRLPL 133
            ::||...|    ||:     :.:..||.:|.|.|           .::..|.::||: ..|.|.:
Zfish    63 SIKYIEPNNPFQAVQEACELMTQGILALVTSTGC-----------ASASALQSLTDAMHIPHLYV 116

  Fly   134 NR--------ALMVPIVENGDEF------PQLILDAKVQQI--LNWKTAVVFVD--------QTI 174
            .|        |..:....:|:.:      |..:.|..:..:  |.|:..:||.|        |..
Zfish   117 QRNAEGSPRTACQLNPSPDGERYTLAARPPVRLGDVMLTLVGELRWQKFIVFYDSDYDIRGLQVF 181

  Fly   175 LEENALLVKSIVHESITNHITPISLILYEINDSLRGQQ---KRVALRQALSQFAPKKHEEMRQQF 236
            |::.:.....:..:.:..:|:.:...|:   .|:|.::   .|..||:|:...:|:..:....|.
Zfish   182 LDQTSRQGLDVSLQRVDRNISGVFSSLF---TSMRTEELNRYRDTLRRAILLLSPRGAQVFIHQA 243

  Fly   237 LVIS--------AFHEDIIEIAETLNMFH--VGNQWMIFVLDMVARDFDAGTVTINLDEGANIAF 291
            :..:        .|..:.|...|.|.:.|  :|...::..:..:.||.....    :.....|:.
Zfish   244 VETNLASKDSHWVFVNEEISDTEILELAHSSLGRMTVVRQIFPLWRDSSVSC----MRNSHRISS 304

  Fly   292 ALNETDPNCQDSL---NCTISEISLALVNAISKITVEEESIYGEISDEEWEAI-------RFTK- 345
            .|.:.......||   |..:.:..|.|.||          .|.::.|.:|.::       :.||
Zfish   305 LLCDPQEGYLQSLEVSNLYLYDSVLMLANA----------FYRKLEDRKWHSMASLNCIRKSTKP 359

  Fly   346 -----------QEKQAEILEYMKEFLKTNAKCSSCARWRVETAITWGKSQENRKFRSTPQRDAKN 399
                       |:.:...|..:.:|::..:  :|..::.:     .|.|     |..|..:|.|
Zfish   360 WNGGWSMLETIQKGRITGLTGIMDFMENGS--NSHVQFEI-----LGTS-----FSETFGKDIK- 411

  Fly   400 RNFEFINIGYWTPVLGFVCQELAFPHIEHHFRNITMDILTVHNPPWQILTKNSNGVIVEHKGIVM 464
                  .:..|..|.| :...|....||:..:.:|:.::|:...|:.::.:|..|....:||..:
Zfish   412 ------RLATWDSVHG-LNGSLKESRIENGMQGVTVKVVTLLEDPFVMVAENILGQPKRYKGFSI 469

  Fly   465 EIVKELSRALNFSYYLHEASAWKEEDSLSTSAGGNESDELVGSMTFRIPYRVVEMVQGNQFFIAA 529
            ::::.|::.|.|.|.:::.:..|....||..:......||:                ..:..:|.
Zfish   470 DVLEALAKILGFKYDIYQVADSKYGSQLSNGSWNGMIGELI----------------NKRADLAV 518

  Fly   530 VAATVEDPDQKPFNYTQPISVQKYSFITRKPDEVSRIYLFTAPFTVETWFCLMGIILLTAPTLYA 594
            .|.|:....:...::::.........:.|||:|...|:...|||.:..|.|:...|.:....::.
Zfish   519 SAITITPERENVVDFSKRYMDYSVGILHRKPEEKINIFSLFAPFDLAVWACIAAAIPVVGVLIFL 583

  Fly   595 INRLAPLKEMRIVGL-------STVKSCFWYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIVLV 652
            :.|:..|:.....|.       :::.|..|.::||.:||||..:..:.:.|:|:|.||:..:::.
Zfish   584 LTRMQMLRSQNPPGAHHASSMSNSLHSAIWIVYGAFVQQGGDSVVGSVALRIVMGSWWLFTLIVC 648

  Fly   653 TTYCGNLVAFLTFPKFQPGVDYLNQLEDHKDIVQYGLRNGTFFERYVQSTTREDFKHYLERAKIY 717
            ::|..||.||||..:....:.....|....|.....:|:...::.:....|..     ||:...|
Zfish   649 SSYTANLAAFLTVSRMDNTIRTFQDLARQMDFAYGTVRDSAVYDYFKAKGTNP-----LEQDSTY 708

  Fly   718 G----------------SAQEEDIEAVKRGERINIDWRINLQLIVQRHFEREKECHFALGRESFV 766
            .                |:..|.|...|:|....: |.:   .:|:.....:.:|...:...|..
Zfish   709 AELWRTISKNNGQDFSVSSPSEGIRKAKKGPYAFL-WDM---AVVEYAALTDDDCTITVSGNSMS 769

  Fly   767 DEQIAMIVPAQSAYLHLVNRHIKSMFRMGFIERWHQMNLPSAGKCNGKS-AQRQVTNHKVNMDDM 830
            .:...:.:...|.|..|:::.|..:...|.::...|...|..|:|:..| :..|.....:.:...
Zfish   770 SKGYGIAMQHGSPYRDLISQKILELQEKGDLDVLKQKWWPRTGRCDLNSHSNAQPDGRSLKLHSF 834

  Fly   831 QGCFLVLLLGFTLALLIVCGEFWYRRFRASRKR 863
            .|.|.:|..|..||.|:...|.|:...|..:::
Zfish   835 AGVFCILAAGLLLACLVAALEMWWNSNRCRQEQ 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	56/274 (20%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	55/283 (19%)
grid1b	XP_009304811.1	PBP1_iGluR_delta_1	25..424	CDD:107387	72/408 (18%)
		ANF_receptor	36..400	CDD:279440	63/371 (17%)
		Periplasmic_Binding_Protein_Type_2	437..809	CDD:304360	75/396 (19%)
		Lig_chan	565..840	CDD:278489	55/283 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591117
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840