DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and grik4

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	XP_021322087.1	Gene:	grik4 / 556582	ZFINID:	ZDB-GENE-070821-5	Length:	965	Species:	Danio rerio

Alignment Length:	953	Identity:	196/953 - (20%)
Similarity:	347/953 - (36%)	Gaps:	273/953 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GLQLSILVPTEANDFSSFLSANASLAVVV-----DHEYMTVHGENILAHFEK------------- 63
            |.:|:|.:..::.:.||..|....|.|.:     |.||.|  ||.:.....|
Zfish    40 GERLAITLAKDSINRSSNRSTTGKLEVDIFELLRDSEYET--GETMCQIMSKGVVAVLGPSASPA 102

  Fly    64 ---ILSDVIRENLRNGGINVKYFSWNAVRLKKDFLAAITVTDCENT-----------WNFYKNTQ 114
               |:|::..|.      .|.|.......:.|......|..|...|           ..|:.::
Zfish   103 SNSIISNICGEK------EVPYVKVAPEDILKVQFPRFTTLDLRPTNTDISMAVAGLLTFFNSS- 160

  Fly   115 ETSILLIAITDSDCPRLPLNRALMVPIVENGDEFPQLILDAKVQQILNWKTAVVFVDQTILEENA 179
             ||.|:.|  .:||                               :||.:   |.:.|.::.:..
Zfish   161 -TSCLICA--QADC-------------------------------LLNLE---VLLRQFLISKET 188

  Fly   180 LLVKSIVHESITNHITPISLILYEINDSLRGQQKRVALRQALSQFAPKKHEEMRQQFLVISA--- 241
            |.|:.:   ..:...||   :|.||.|.                         :...:::.|
Zfish   189 LSVRML---DDSQDPTP---LLKEIRDD-------------------------KTATIIVDANAT 222

  Fly   242 FHEDIIEIAETLNMFHVGNQWMIFVLDM-VARDFDAGTVTINLDEGANIAFAL-NETDPNCQD-- 302
            ....|:|.|..|.|..|...:::..|:. :.|..|.....:|:     :.|:: |.|.|..||
Zfish   223 MSHVILERASELGMLSVYYTYILTSLEFSLLRLDDLADQRVNI-----VGFSVFNRTHPFFQDFV 282

  Fly   303 -SLNCTISE-----------ISLALV-NAISKI--TVEEESIYGEISDEEWEAIRFTKQEKQAEI 352
             |||.:..|           :|.||: :|:..:  .|:|
Zfish   283 LSLNRSWQENCDHAPFAGTPLSSALLFDAVHTVVAAVQE-------------------------- 321

  Fly   353 LEYMKEFLKTNAKCSSCARWRVETAI-TWGKSQE------NRKFRSTPQRD------AKNRNFEF 404
            |...:....|...|.|...|...|:: .:.:..|      :.:|.|..||.      .:|.....
Zfish   322 LNRSQNVGATQLSCKSSKIWEHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALRIMQNSRDGL 386

  Fly   405 INIGYWTPVLGFVCQELAFP--HIEHHFRNITMDILTVHNPPWQILTKN-----SNGVIVEHKGI 462
            ..||.|....| :..|...|  ::.....|.|:.|.|:...|:.:|..|     .|.   .::|.
Zfish   387 RQIGQWHSEQG-LSMERKLPSLNVTDTLFNTTLTITTILENPYVMLRANHQELEGND---RYEGF 447

  Fly   463 VMEIVKELSRALNFSYYLHEASAWKEEDSLSTSAGGNESDELVGSMTFRIP-------YRVVEMV 520
            .::::|||:..|.|.|.:                      .|||...:.:|       ..|.|::
Zfish   448 CVDMLKELADILKFKYRI----------------------RLVGDGVYGVPGANGTWTGMVGELI 490

  Fly   521 QGNQFFIAAVAATVEDPDQKPFNYTQP-----ISVQKYSFITRKPDEVSRIYLFTAPFTVETWFC 580
             ..:..:|..|.|:....:|..::::|     ||:.....|.|:|...|    |..||:...|..
Zfish   491 -SRKADLAVAALTITAEREKVIDFSKPFMTLGISIMYRVHIGRRPGYFS----FLDPFSPGVWLF 550

  Fly   581 LMGIILLTAPTLYAINRLAPLKEMR-----------IVGLSTVKSCFWYIFGALLQQGGMYLPTA 634
            ::...|..:..|:.:.||.|.:...           ::...::.:.||:..|..:|||....|.|
Zfish   551 MLLAYLAVSCVLFLVARLTPYEWYNPHPCLKGRCSLLINQYSLGNSFWFPVGGFMQQGSTIAPRA 615

  Fly   635 DSGRLVVGFWWIVVIVLVTTYCGNLVAFLTFPKFQPGVDYLNQLEDHKDIVQYGLRNG----TFF 695
            .|.|.|.|.||...::::::|..||.||||..:.:..::.::.|.| :..::||..:|    |||
Zfish   616 LSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESVDDLAD-QTAIEYGTMHGGSTMTFF 679

  Fly   696 E--RYVQSTTREDFKHYLERAKIYGSAQEEDIEAVKRGERINIDWRINLQLIVQRHFEREKECHF 758
            :  ||.......:|. |.::..::..:.||.|..|     :|.::...|:..:..:: |::.|:.
Zfish   680 QNSRYQTYQRMWNFM-YSKQPSVFVKSTEEGIARV-----LNSNYAYLLESTMNEYY-RQRNCNL 737

  Fly   759 A-LGRESFVDEQ---IAMIVPAQSAY---LHLVNRHIKSMFRMGFIER--WHQMNLPSAGKCNGK 814
            . :|  ..:|.:   |.|  |..|.|   ..|....::...|:..::|  |      ..|||..:
Zfish   738 TQIG--GLLDTKGYGIGM--PLGSVYRDEFDLAILRLQEENRLEILKRKWW------DGGKCPKE 792

  Fly   815 SAQRQVTNHKVNMDDMQGCFLVLLLGFTLALLIVCGEF-WYRR 856
            ...|.   ..:.|:::.|.|:||:.|..:|:.:...|| |..|
Zfish   793 EDHRA---KGLGMENIGGIFVVLVCGLLVAIFMAVLEFVWMLR 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	70/301 (23%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	65/285 (23%)
grik4	XP_021322087.1	Periplasmic_Binding_Protein_Type_1	26..400	CDD:324556	86/468 (18%)
grik4	XP_021322087.1	PBP2_iGluR_kainate_KA1	425..785	CDD:270442	89/407 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590966
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940