DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and grik2

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	XP_021322472.1	Gene:	grik2 / 556013	ZFINID:	ZDB-GENE-080414-1	Length:	908	Species:	Danio rerio

Alignment Length:	927	Identity:	189/927 - (20%)
Similarity:	350/927 - (37%)	Gaps:	212/927 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 HGENILAHFEKILSDVIRENLRNGGINVKY-FSWNAVRLKKDFLAAITVTDCENTWNFYKNTQET 116
            ||...:..|..|...:  |:..:|...:.: |:.|.:...:..|...|:|              .
Zfish    30 HGMPHVLRFGGIFESI--ESGPSGAEELAFKFALNTINRNRTLLPNTTLT--------------Y 78

  Fly   117 SILLIAITDS------DCPRLPLN--------------------RALMVP---------IVENGD 146
            .|..|.|.||      .|.:|.|.                    .||.||         :.:|.|
Zfish    79 DIQRINIHDSFEASRKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTKWKHQVSDNRD 143

  Fly   147 EF-----------PQLILDAKVQQILNWKT-AVVFVDQTILEENALLVKSIVHESITNHITPISL 199
            .|           .:.|||  :.....||| .||:.|.|.|.....|:|:....:|
Zfish   144 SFYVNLYPDFSSLSRAILD--LVHFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNI--------- 197

  Fly   200 ILYEINDSLRGQQKRVALRQ--ALSQFAPKKHEEMR--QQFLVI-SAFHE---DIIEIAETLNMF 256
                          |:.:||  |.::.|....:||:  ::|.|| ...||   .|::.|..:.|.
Zfish   198 --------------RLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCGHEMAAGILKQALAMGMM 248

  Fly   257 HVGNQWMIFVLDMVARDFDAGTVTINLDEGANI-AFALNETDPNCQDSLNCTISEISLALVNAIS 320
            .....::...||:.|.|.:....:     |.|: .|.:..|: |.|  ::..|.:.|:..:.|..
Zfish   249 TEYYHYIFTTLDLFALDVEPYRYS-----GVNMTGFRILNTE-NSQ--VSSIIEKWSMERLQAPP 305

  Fly   321 K---------ITVEEESIYGEISDEEWEAIRFTKQEKQAEILEYMKEFLKTNAKCSSCARWRVET 376
            |         :|.:...:|        :|:...     |..::...:...::.:|:....||...
Zfish   306 KPDSGLLDGFMTTDAALMY--------DAVHVV-----AVAVQQSPQITVSSLQCNRHKPWRFGN 357

  Fly   377 AIT-------W----GKSQENRK--FRSTPQRDA---KNRNFEFINIGYWTPVLGFVC---QELA 422
            ...       |    |:...||.  .|:....|.   |....|  .||.|.|..|...   |:..
Zfish   358 RFMTLIKEAHWDGLTGRINFNRTNGLRTDFDLDVISLKEEGLE--KIGTWDPASGLNMTENQKGK 420

  Fly   423 FPHIEHHFRNITMDILTVHNPPWQILTKNSNGVIVEHK--GIVMEIVKELSRALNFSYYLH--EA 483
            ..::.....|.::.:.|:...|:.:..|:...:....:  |..:::::||:..|.|.|.|.  |.
Zfish   421 TANVTDSLSNRSLVVSTILEEPYVMFKKSDKPLYGNDRFEGYCVDLLRELAAILGFGYELRLVED 485

  Fly   484 SAWKEEDSLSTSAGGNESDELVGSMTFRIPYRVVEMVQGNQFFIAAVAATVEDPDQKPFNYTQPI 548
            ..:..:|..|....|                 :|..:..::..:|.....:....:|..::::|.
Zfish   486 GRYGAQDESSGQWNG-----------------MVRELMDHKADLAVAPLAITYVREKVIDFSKPF 533

  Fly   549 SVQKYSFITRKPDEVS-RIYLFTAPFTVETWFCLMGIILLTAPTLYAINRLAPLK---------E 603
            .....|.:.|||:..: .::.|..|.:.:.|..::...|..:..|:.|.|.:|.:         :
Zfish   534 MTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPD 598

  Fly   604 MRIVGLS-TVKSCFWYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIVLVTTYCGNLVAFLTFPK 667
            ..:|..: |:.:.||:..|||:|||...:|.|.|.|:|.|.||...::::::|..||.||||..:
Zfish   599 SDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVER 663

  Fly   668 FQPGVDYLNQLEDHKDIVQYG-LRNG---TFFERYVQSTTREDFKHYL--ERAKIYGSAQEEDIE 726
            .:..:|..:.|.....| :|| :.:|   |||:: .:.:|.:....::  .|..:...:.||.||
Zfish   664 MESPIDSADDLAKQTKI-EYGVVEDGSTMTFFKK-TKISTYDKMWEFMSSRRHSVMVKSIEEGIE 726

  Fly   727 AVKRGERINIDWRINLQLIVQRHFEREKECHFA-LGRESFVDEQIAMI-VPAQSAYLHLVNRHIK 789
            .|...:...:.....::.:.||:      |:.. :|  ..:|.:...: .|..|.|...:...|.
Zfish   727 RVLTSDYAFLMESTTIEFVTQRN------CNLTQIG--GLIDSKAYGVGTPMGSPYRDKITIAIL 783

  Fly   790 SMFRMGFI----ERWHQMNLPSAGKCNGKSAQRQVTNHKVNMDDMQGCFLVLLLGFTLALLIVCG 850
            .:...|.:    |:|        .:.||...:.......:.:.::.|.|:||..|..|::.:..|
Zfish   784 QLQEEGKLHMMKEKW--------WRGNGCPEEENKEASALGVQNIGGIFIVLAAGLVLSVFVAVG 840

  Fly   851 EFWYR-RFRASRKRRQF 866
            ||.|: :..|..::|.|
Zfish   841 EFLYKSKQNAQLEKRSF 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	65/286 (23%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	63/281 (22%)
grik2	XP_021322472.1	PBP1_iGluR_Kainate	37..414	CDD:380605	87/440 (20%)
grik2	XP_021322472.1	Periplasmic_Binding_Protein_Type_2	430..800	CDD:419667	84/404 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591386
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840