DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and CG11155

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster

Alignment Length:	850	Identity:	175/850 - (20%)
Similarity:	322/850 - (37%)	Gaps:	209/850 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 TSILLIAITDSDCPRLPLNRALMVPIVE-------NGDEF------PQLILDAKVQQI---LNW- 163
            |..||.:...|.|      .|..:|.:|       |..||      ...:|....:.|   |||
  Fly   115 TDALLASHVQSIC------EAYDIPHIEGRIDLEYNSKEFSINLYPSHTLLTLAYRDIMVYLNWT 173

  Fly   164 KTAVVFVDQTILEENALLVKSIVHESITNHITPISLILYEINDSLRGQQKRVALRQALSQFAPKK 228
            |.|:::      ||:..|. :::|.|     |.....:|              :|||    :|..
  Fly   174 KVAIIY------EEDYGLF-NLMHSS-----TETKAEMY--------------IRQA----SPDS 208

  Fly   229 HEE----MRQQFLV----------ISAFHEDIIEIAETLNMFHVGNQWMIFVLDMVA---RDFDA 276
            :.:    :||:.:.          |.:|...|:::....:.:|    :|....|:..   .||..
  Fly   209 YRQVLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYH----YMFTTFDLETYDLEDFRY 269

  Fly   277 GTVTINLDEGANIAFALNETDPNCQDSLNCTISEISLALVNAISKITVEE-ESIYGEISDEEWEA 340
            .:|.|.       ||.|.:.|           |:..|.::|.:.|:.... ::|.|....:...|
  Fly   270 NSVNIT-------AFRLVDVD-----------SKRYLEVINQMQKLQHNGLDTINGSPYIQTESA 316

  Fly   341 IRFTKQEKQAEILEYM-----KEFLKTNAKCSSCARW--------RVETAITWGKSQENRKFRST 392
            :.|......|..|.::     :.|...|..|:|...|        ::..|||.|       ...|
  Fly   317 LMFDSVYAFANGLHFLNLDNHQNFYIKNLSCTSDQTWNDGISLYNQINAAITDG-------LTGT 374

  Fly   393 PQRDAKNRNF-----------EFINIGYWTPVLGF-VCQELAFPHIEHHFRNITMDILTVHNPPW 445
            .|.....||.           :...:|||.|..|. :....||  .:.:..|||:.::|....|:
  Fly   375 VQFVEGRRNIFKLDILKLKQEKIQKVGYWHPDDGVNISDPTAF--YDSNIANITLVVMTREERPY 437

  Fly   446 QIL--TKNSNGVIVEHKGIVMEIVKELSRALNFSY------------YLHEASAWKEEDSLSTSA 496
            .::  .||..|.: ..:|..::::|.::..:.|.|            |:.|.::|.
  Fly   438 VMVKEDKNLTGNL-RFEGFCIDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWN--------- 492

  Fly   497 GGNESDELVGSMTFRIPYRVVEMVQGNQFFIAAVAATVEDPDQKPFNYTQPISVQKYSFITRKP- 560
                              .:|:.:...:..:|..:.|:....:...::|:|........:.:.|
  Fly   493 ------------------GIVQELMERRADLAVASMTINYARESVIDFTKPFMNLGIGILFKVPT 539

  Fly   561 DEVSRIYLFTAPFTVETWFCLMGIILLTAPTLYAINRLAP---------LKEMRIV-GLSTVKSC 615
            .:.:|::.|..|..:|.|..::...:|.:..|:.:.|.:|         .||..|| ...::.:.
  Fly   540 SQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMARFSPYEWKNPHPCYKETDIVENQFSISNS 604

  Fly   616 FWYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIVLVTTYCGNLVAFLTFPKFQPGVDYLNQLED 680
            ||:|.|..|:||....|.|.|.|:|.|.|:...::::::|..||.||||..:....::..:.|.:
  Fly   605 FWFITGTFLRQGSGLNPKATSTRIVGGCWFFFCLIIISSYTANLAAFLTVERMISPIESASDLAE 669

  Fly   681 HKDIVQYGLRNG----TFFERYVQSTTREDFKHYLERAK--IYGSAQEEDIEAVKRGERINIDWR 739
            ..:| .||...|    ||| |..:....:....|:|..|  ::....|:.|:.|..|....:...
  Fly   670 QTEI-SYGTLEGGSTMTFF-RDSKIGIYQKMWRYMENRKTAVFVKTYEDGIKRVMEGSYAFLMES 732

  Fly   740 INLQLIVQRHFEREKECHFA-LGRESFVDEQ-IAMIVPAQSAYLHLVNRHIKSMFRMGFI----E 798
            ..|...|||      :|:.. :|  ..:|.: ..:..|..|.:...::..|..:...|.|    :
  Fly   733 TMLDYAVQR------DCNLTQIG--GLLDSKGYGIATPKGSPWRDKISLAILELQEKGIIQILYD 789

  Fly   799 RWHQMNLPSAGKCNGKSAQRQVTNHKVNMDDMQGCFLVLLLGFTLALLIVCGEFWYRRFRASRKR 863
            :|.:   .:...||.....::...:.:.::::.|.|:|||.|..||:::...||.:.    |||.
  Fly   790 KWWK---NTGDVCNRDDKSKESKANALGVENIGGVFVVLLCGLALAVVVAIFEFCWN----SRKN 847

  Fly   864 RQFTN 868
            ....|
  Fly   848 LNTEN 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	63/296 (21%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	64/281 (23%)
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	73/359 (20%)
		ANF_receptor	61..393	CDD:279440	68/342 (20%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	84/406 (21%)
		Lig_chan	555..829	CDD:278489	67/286 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462923
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940