DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and gria4a

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_999971.1	Gene:	gria4a / 407735	ZFINID:	ZDB-GENE-020125-7	Length:	898	Species:	Danio rerio

Alignment Length:	926	Identity:	163/926 - (17%)
Similarity:	313/926 - (33%)	Gaps:	274/926 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 FYKNT-QETSILLIAI----TDSDCPRLPLNRALMVPIVENGDEF-------------------- 148
            |.:|| ||.:...:||    |..:....|.|....|..:|..:.|
Zfish    28 FIRNTDQEYTAFRLAIFLHNTSPNATEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGL 92

  Fly   149 ----------------------PQLILDAKVQQIL-----------------NWKTAVVFVD--- 171
                                  |....:.:.|.:|                 :|...|...|
Zfish    93 YDKRSVHTLTSFCSALHISLVTPSFPAEGETQFVLQLRPSIRGALLSLLDHYDWSRFVFLYDTDR 157

  Fly   172 -----QTILE---ENALLVKSIVHESITNHITPISLILYE--INDSLRGQQKRVALRQALSQFAP 226
                 |.|:|   :|...|.:|..|:..:       ..|.  :.|..|.|:|:         |..
Zfish   158 GYAVLQAIMEKAGQNGWQVSAICVENFND-------ASYRRLLEDLDRRQEKK---------FVI 206

  Fly   227 KKHEEMRQQFLVISAFHEDIIEIAETLNMFHVGNQWMIFVLDMVARDFDAGTVTINLDE----GA 287
            ....|..|..|      |.|:.:.:.:..:|.          :||   :.|...|:|:.    ||
Zfish   207 DLEAERLQNIL------EQIVSVGKHVKGYHY----------IVA---NLGFKDISLERFMHGGA 252

  Fly   288 NIAFALNETDPNCQDSLNCTISEISLALVNAISKITVEEESIYGEISDEEWEAI----RFTKQEK 348
            |:.                     ...||:....:.::....:.::...|:...    |:|....
Zfish   253 NVT---------------------GFQLVDFSKPMVIKLMQRWNKLDQREYPGSESPPRYTSSLT 296

  Fly   349 QAEILEYMKEF---------LKTNAKCSSCARWRVETAITWGKSQENRKFRSTPQRDAKNRNFEF 404
            ...:|...:.|         :........|.   ...|..|.:..:..:.....:......|.:|
Zfish   297 YDGVLVMAEAFRNLRRQKIDISRRGNAGDCL---ANPAAPWNQGIDMERTLKQVRIQGLTGNIQF 358

  Fly   405 ------IN---------------IGYWTPV--LGFVCQELAFPHIEHHFRNITMDILTVHNPPWQ 446
                  :|               ||||..:  |..|..||:..: :....|.|:.:.|:...|:.
Zfish   359 DHYGRRVNYTMDVFELKSNGPRKIGYWNDLDKLVLVQNELSMGN-DSAMENRTVIVTTIMEGPYV 422

  Fly   447 ILTKN-----SNGVIVEHKGIVMEIVKELSRALNFSYYLH------------EASAWKEEDSLST 494
            :|.||     .|   .:.:|..:::..|:::.:...|.:.            |...|
Zfish   423 MLKKNWEMYEGN---EQFEGYCVDLASEVAKHIGIKYKISIVLDGKYGARDPETKIW-------- 476

  Fly   495 SAGGNESDELVGSMTFRIPYRVVEMVQGN-QFFIAAVAATVEDPDQKPFNYTQPISVQKYSFITR 558
                   :.:||           |:|.|. :..:|.:|.|:  ..::..::::|......|.:.:
Zfish   477 -------NGMVG-----------ELVYGKAEIAVAPLAITL--VREEVIDFSKPFMSLGISIMIK 521

  Fly   559 KPDEVS-RIYLFTAPFTVETWFCLMGIILLTAPTLYAINRLAPLK-------------------- 602
            ||.:.. .::.|..|...|.|.|::...:..:..|:.::|.:|.:
Zfish   522 KPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEEGSDGPPSDQPPN 586

  Fly   603 EMRIVGLSTVKSCFWYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIVLVTTYCGNLVAFLTFPK 667
            |..|.      :..|:..||.:|||..:.|.:.|||:|.|.||...::::::|..||.||||..:
Zfish   587 EFGIF------NSLWFSLGAFMQQGCDFTPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVER 645

  Fly   668 FQPGVDYLNQLEDHKDIVQYGLRNGT---FFERYVQSTTREDFKHYLERAK--IYGSAQEEDIEA 727
            ....::....|....:|....|.:|:   ||.| .:....|....|::.|:  ::.....|.:..
Zfish   646 MVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRR-SKIAVYEKMWSYMKSAEPTVFTKTTAEGVAR 709

  Fly   728 VKRGERINIDWRINLQLIVQRHFEREKECHFALGRESFVDEQIAMIVPAQSAYLHLVNRHIKSMF 792
            |::.:.   .:...|:..:..:.|:.|.|.......:...:...:..|..|.....||..:..:.
Zfish   710 VRKSKG---KYAFLLESTMNEYTEQRKPCDTMKVGGNLDSKGYGVATPKGSQLGTPVNLAVLKLS 771

  Fly   793 RMGFIER-----WHQMNLPSAGKCNGK-SAQRQVTNHKVNMDDMQGCFLVLLLGFTLALLIVCGE 851
            ..|.:::     |:     ..|:|..| |..:..::..:::.::.|.|.:|:.|..||:|:...|
Zfish   772 EAGVLDKLKNKWWY-----DKGECGPKDSGSKDKSSQALSLSNVAGVFYILVGGLGLAMLVALVE 831

  Fly   852 FWYRRFRASRKRRQFT 867
            |.|:. ||..|:.:.|
Zfish   832 FCYKS-RAEAKKLKLT 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	62/309 (20%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	57/290 (20%)
gria4a	NP_999971.1	PBP1_iGluR_AMPA_GluR4	23..393	CDD:107383	64/423 (15%)
		ANF_receptor	34..375	CDD:279440	56/399 (14%)
		PBP2_iGluR_AMPA_GluR4	408..790	CDD:270445	79/427 (19%)
		Lig_chan	540..821	CDD:278489	58/295 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591372
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940