DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir93a and Ir75a

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_649012.2	Gene:	Ir75a / 39982	FlyBaseID:	FBgn0036757	Length:	629	Species:	Drosophila melanogaster

Alignment Length:	811	Identity:	146/811 - (18%)
Similarity:	255/811 - (31%)	Gaps:	283/811 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 ILLIAITDSDCPRLPLNRALMVPIVENGDEFPQLILDAKVQQ--ILNWKTAVVFVDQTILEENAL 180
            |:|.....|| ..|...:..|.||      .|.|:....||.  :|||
  Fly    22 IVLFHCWQSD-ESLKFAQQFMKPI------HPILVYHQFVQMRGVLNW----------------- 62

  Fly   181 LVKSIVHESITNHITPISLILYEINDSLRGQQKRVALRQALSQFAPKKHEEMRQQFLVISAFHED 245
               |.:..|...|..|...|..:|    :..|.:..|.:|..:....:|
  Fly    63 ---SHLELSYMGHTQPTLAIYVDI----KCDQTQDLLEEASREQIYNQH---------------- 104

  Fly   246 IIEIAETLNMFH---VGNQ-----WMIFVLDMVARDFDAGTVTINL-DEGANIAFALNETDPNCQ 301
                      :|   ||||     :.:|.|..::.|.|...|...: |...::|:|:::...|.:
  Fly   105 ----------YHWLLVGNQSKLEFYDLFGLFNISIDADVSYVKEQIQDNNDSVAYAVHDVYNNGK 159

  Fly   302 ---DSLNCTISEISLALVNAISKIT-----VEEESIYGE---------------------ISDEE 337
               ..||.|.|. .::....:.:.|     :::.|.||.                     :||:
  Fly   160 IIGGQLNVTGSH-EMSCDPFVCRRTRHLSSLQKRSKYGNREQLTDVVLRVATVVTQRPLTLSDD- 222

  Fly   338 WEAIRFTKQEKQAEILEYMKEFLKTNAKCSSCARWRVETAITWGKSQENRKFRSTPQRDAKNRNF 402
             |.|||..||....|              .|.||:
  Fly   223 -ELIRFLSQENDTHI--------------DSLARF------------------------------ 242

  Fly   403 EFINIGYWTPVLGFVCQELAFPHIEHHFRNITMDILTVHNPPWQILTKNSNGVIVEHKGIVMEIV 467
                        ||            |...|..|:|..
  Fly   243 ------------GF------------HLTLILRDLLHC--------------------------- 256

  Fly   468 KELSRALNFSYYLHEASAWKEEDSLSTSAGG--NESDELVGSMTFRIPYRVVEMVQGNQFFIAAV 530
                 .:.|.:    :.:|.:.|.:..|.|.  :::.:|..:.:.        ..:|...:::|:
  Fly   257 -----KMKFIF----SDSWSKSDVVGGSVGAVVDQTADLTATPSL--------ATEGRLKYLSAI 304

  Fly   531 AATVEDPDQKPFNYTQPISVQKYSFITRKPDEVS-RIYLFTAPFTVETWFCLMGIILLTAPTLY- 593
            ..|         .:.:.:.      |.|.|.... |..:|..||:...|:...|::.|....|:
  Fly   305 IET---------GFFRSVC------IFRTPHNAGLRGDVFLQPFSPLVWYLFGGVLSLIGVLLWI 354

  Fly   594 ----AINRLAPLKEMRIVGLSTVKSCFWYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIVLVTT 654
                ...|:.  |..|:..|.::.|.|...|||...|....:|.:..|||:....:::..::...
  Fly   355 TFYMECKRMQ--KRWRLDYLPSLLSTFLISFGAACIQSSSLIPRSAGGRLIYFALFLISFIMYNY 417

  Fly   655 YCGNLVAFLTFPKFQPGVDYLNQLEDHKDIVQYGLRNGTFFERYVQSTTREDFKHYLERAKIYGS 719
            |...:|:.|.....:..:..:.||.:..  :..||....|.:.|:..:...:...:::| ||...
  Fly   418 YTSVVVSSLLSSPVKSKIKTMRQLAESS--LTVGLEPLPFTKSYLNYSRLPEIHLFIKR-KIESQ 479

  Fly   720 AQEEDI-----EAVKRGERINIDWRINLQ-----LIVQRHFEREKECHFALGRESFVDEQIAMIV 774
            .|..::     :.|.| .|.|..:....:     ..|:|:|..::.|          |....:..
  Fly   480 TQNPELWLPAEQGVLR-VRDNPGYVYVFETSSGYAYVERYFTAQEIC----------DLNEVLFR 533

  Fly   775 PAQSAYLHL-VNRHIKSMFRMGFI------------ERWHQMNLPSAGKCNGKSAQRQVTNHKVN 826
            |.|..|.|| .|...|.:||:.|:            ..|..|.|...       ||..|..  |.
  Fly   534 PEQLFYTHLHRNSTYKELFRLRFLRILETGVYRKQRSYWVHMKLHCV-------AQNFVIT--VG 589

  Fly   827 MDDMQGCFLVLLLGFTLALLIVCGEFWYRRF 857
            |:.:....|:|:....|.::|:..|..::||
  Fly   590 MEYVAPLLLMLICADILVVVILLVELAWKRF 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	46/275 (17%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	58/287 (20%)
Ir75a	NP_649012.2	Lig_chan	337..603	CDD:306551	60/290 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462742
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940