DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir93a and gria3b

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_938174.1	Gene:	gria3b / 368416	ZFINID:	ZDB-GENE-030616-53	Length:	883	Species:	Danio rerio

Alignment Length:	818	Identity:	140/818 - (17%)
Similarity:	295/818 - (36%)	Gaps:	192/818 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 PQLILDAKVQQIL-----------------NWKTAVVFVDQTILEENALLVKSIVHESITNHITP 196
            |...:|:.||.::                 .|...|...|   .:....::::|:..::.|:...
Zfish   117 PSYPIDSDVQFVIQMRPPLKGAVLSLLSHYKWDKFVYLYD---TDRGFSILQAIMEAAVANNWQV 178

  Fly   197 ISLILYEINDSLRGQQKRVALRQALSQFAPKKHEEMRQQFLV------ISAFHEDIIEIAETLNM 255
            .:..:..|.|.           |...:...:......:::|:      |:...|.::.:.:....
Zfish   179 TARSVGSITDP-----------QEFRRIIEEMDRRQEKRYLIDCEVDRINVILEQVVTLGKNSRG 232

  Fly   256 FHVGNQWMIFVLDMVARDFDAGTVTINLDE----GANIAFALNETDPNCQDSLNCTISEISLALV 316
            :|.          ::|   :.|...|:||:    ||||:                     ...::
Zfish   233 YHY----------IIA---NLGFTNISLDKVFLGGANIS---------------------GFQII 263

  Fly   317 NAISKITVEEESIYGEISDEEW-EA----IRFTKQEKQ------AEILEYMKEFLKTNAKCSSCA 370
            |..:.:..:....:..:.:.|: ||    :::|.....      ||...|::......::..|..
Zfish   264 NPENLVVQQFLQRWDRLDEREFPEAKNTPLKYTSALSYDAILVIAEAFRYLRRQRVDVSRRGSAG 328

  Fly   371 RWRVETAITWGKSQENRKFRSTPQRDAKNRNFEFIN---------------------IGYWTPVL 414
            ......|:.|.:..:..:.....|......|.:|.:                     ||||....
Zfish   329 DCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDSFGRRTNYTIDVYEMKTGGPRKIGYWNEFE 393

  Fly   415 GFV-CQELAFPHIEHHFRNITMDILTVHNPPWQILTKN-----SNGVIVEHKGIVMEIVKELSRA 473
            .|| ..:..|.:......|.|:.:.|:...|:.:..||     .|   .:::|..:::..|:::.
Zfish   394 RFVNIMDQQFTNDSSSVENRTIVVTTIMEAPYVMYKKNHMHLEGN---EKYEGYCVDLASEIAKH 455

  Fly   474 LNFSYYLH------------EASAWKEEDSLSTSAGGNESDELVGSMTFRIPYRVVEMVQGNQFF 526
            :...|.|.            |..:|               :.:||           |:|.| :..
Zfish   456 VGIKYRLSIVMDGKYGARDPETKSW---------------NGMVG-----------ELVYG-RAD 493

  Fly   527 IAAVAATVEDPDQKPFNYTQPISVQKYSFITRKPDEVS-RIYLFTAPFTVETWFCLMGIILLTAP 590
            ||....|:....::..::::|......|.:.:||.:.. .::.|..|...|.|.|::...:..:.
Zfish   494 IAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSV 558

  Fly   591 TLYAINRLAPLKEMRIVGLSTVK---------------SCFWYIFGALLQQGGMYLPTADSGRLV 640
            .|:.::|.:|. |.::.....||               :..|:..||.:|||....|.:.|||:|
Zfish   559 VLFLVSRFSPY-EWQLDETDEVKDPQTPPDPPNDFGIFNSLWFSLGAFMQQGCDISPRSLSGRIV 622

  Fly   641 VGFWWIVVIVLVTTYCGNLVAFLTFPKFQPGVDYLNQLEDHKDIVQYGLRNGT---FFERYVQST 702
            .|.||...::::::|..||.||||..:....::....|....:|....|.:|:   ||.| .:..
Zfish   623 GGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRR-SKIA 686

  Fly   703 TREDFKHYLERAK--IYGSAQEEDIEAVKRGERINIDWRINLQLIVQRHFEREKECHFALGRESF 765
            ..|....|::.|:  ::.....:.:..|::.:.   .:...|:..:..:.|:.|.|.......:.
Zfish   687 VYEKMWSYMKSAEPSVFAKTTPDGVARVRKSKG---KFAFLLESTMNEYIEQRKPCDTMKVGGNL 748

  Fly   766 VDEQIAMIVPAQSAYLHLVNRHIKSMFRMGFIER-----WHQMNLPSAGKCNGKSAQRQVTNHKV 825
            ..:...:..|..||..:.||..:..:...|.:::     |:     ..|:|.......:.....:
Zfish   749 DSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWY-----DKGECGSGGGDSKDKTSAL 808

  Fly   826 NMDDMQGCFLVLLLGFTLALLIVCGEFWYRRFRASRKR 863
            ::.::.|.|.:|:.|..||:::...||.|:. ||..||
Zfish   809 SLSNVAGVFYILVGGLGLAMMVALIEFCYKS-RAEAKR 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	63/303 (21%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	56/284 (20%)
gria3b	NP_938174.1	Periplasmic_Binding_Protein_Type_1	25..396	CDD:299141	43/326 (13%)
		ANF_receptor	36..379	CDD:279440	39/309 (13%)
		PBP2_iGluR_AMPA	412..794	CDD:270433	80/421 (19%)
		Lig_chan	544..824	CDD:278489	57/289 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591399
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940