DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and Ir40a

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_610140.4	Gene:	Ir40a / 35449	FlyBaseID:	FBgn0259683	Length:	732	Species:	Drosophila melanogaster

Alignment Length:	734	Identity:	123/734 - (16%)
Similarity:	248/734 - (33%)	Gaps:	196/734 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   281 INLDEGANIAFALNETDPNCQDSLNCTISEISLALVNAISKITVEEESIY-----GEISDEEWEA 340
            |..|| ::.|.||.:.....|.|....::..||||.:.:.:   :|.::|     ..:....:::
  Fly    25 IGNDE-SDTAIALTQIVRGLQQSSLAILALPSLALSDGVCQ---KERNVYLDDFLQRLHRSNYKS 85

  Fly   341 IRFTKQEKQAEILEYMKEFLKTNAKCSSC-----------------------------ARWRVET 376
            :.|::.|.   ..::::|.|:...:|.|.                             |||...:
  Fly    86 VVFSQTEL---FFQHIEENLQGANECISLILDEPNQLLNSLHDRHLGHRLSLFIFYWGARWPPSS 147

  Fly   377 AITWGKSQENRKFR--------STPQRDA-----------KNRNFEFINIGYW----------TP 412
            .:.        :||        :.|::.|           .:...:.:|   |          .|
  Fly   148 RVI--------RFREPLRVVVVTRPRKKAFRIYYNQARPCSDSQLQLVN---WYDGDNLGLQRIP 201

  Fly   413 VLGFVCQELAFPHIEHHFRNITMDILTVHNPPWQILTKNSNGVIVEHKGIVMEIVKE-------- 469
            :|.......|      :|:..|..:...|:|||..:|..:|....:.:...::.:::
  Fly   202 LLPTALSVYA------NFKGRTFRVPVFHSPPWFWVTYCNNSFEEDEEFNSLDSIEKRKVRVTGG 260

  Fly   470 --------LSRALNFSYYLHEASAWKEEDSLSTSAGGNESDELVGSMTFRIPYRVVEMVQGNQ-- 524
                    ||:.:||.:...||.. :.:.|:.:..|.:.:|...|.         :.::|..|
  Fly   261 RDHRLLMLLSKHMNFRFKYIEAPG-RTQGSMRSEDGKDSNDSFTGG---------IGLLQSGQAD 315

  Fly   525 FFIAAVAATVEDPDQKPFNYTQPISVQKYSFITRKPDEVSRIYLFTAPFTVETWFCLMGIILLTA 589
            ||:..|..:.|  .:|...::........:|.|..|..::.......||..:.|..|:..|:.:.
  Fly   316 FFLGDVGLSWE--RRKAIEFSFFTLADSGAFATHAPRRLNEALAIMRPFKQDIWPHLILTIIFSG 378

  Fly   590 PTLYAI---------------------------------NRLAPLKEMRIVGLSTV-----KSCF 616
            |..|.|                                 .||..||...::....:     :.|.
  Fly   379 PIFYGIIALPYIWRRRWANSDVEHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQLFQKCI 443

  Fly   617 WYIFGALLQQGGMYLPTADSGR-LVVGFWWIVVIVLVTTYCGNLVAFLTFPKFQPGVDYLNQLED 680
            |:.....|:|....|......: |.:.:|.....||...|...|.:....|..:|.::.|.:|:.
  Fly   444 WFTLRLFLKQSCNELHNGYRAKFLTIVYWIAATYVLADVYSAQLTSQFARPAREPPINTLQRLQA 508

  Fly   681 ---HKDIVQYGLRNGTFFERYVQSTTREDFK--HYLERAKIYGSAQEEDIEAVKRG--------- 731
               |.....|..:..:..|.....|  |.|:  :.|.|.::....|...|::|:.|
  Fly   509 AMIHDGYRLYVEKESSSLEMLENGT--ELFRQLYALMRQQVINDPQGFFIDSVEAGIKLIAEGGE 571

  Fly   732 ERINIDWRINLQLIVQRHFEREKECHFALGRESFVDEQIAMIVPAQSAYLHLVNRHIKSMFRMGF 796
            ::..:..|..|...||::...    :|.|.::.:. ...|:.|.....:|..:|..:..:|..|.
  Fly   572 DKAVLGGRETLFFNVQQYGSN----NFQLSQKLYT-RYSAVAVQIGCPFLGSLNNVLMQLFESGI 631

  Fly   797 IERWHQMNLPS-----------AGKCNGKSAQRQVTNHK--------VNMDDMQGCFLVLLLGFT 842
            :::........           .|....|:::.......        :|:..:||.|:.|.:|..
  Fly   632 LDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDSTVISPLNLRMLQGAFIALGVGSL 696

  Fly   843 LALLIVCGEFWYRRFRASR 861
            .|.:|:..|..:.:...:|
  Fly   697 AAGVILLLEIVFIKLDQAR 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	57/327 (17%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	55/331 (17%)
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	24/133 (18%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	20/104 (19%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	27/147 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462894
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840