DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and clumsy

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster

Alignment Length:	925	Identity:	191/925 - (20%)
Similarity:	344/925 - (37%)	Gaps:	222/925 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 LAHF----EKILSDVIRENLRNGGINVKYFSWNAVRLKKD--FLAAITVTDCENTWNFYKNTQET 116
            |.||    ..:|:|:.|.....|.|...         .||  .:|..|..|..|.  ..:|.:..
  Fly     6 LTHFLLIALPVLADIDRSQFMVGSIFTS---------DKDESEIAFRTAVDRANI--LERNVELV 59

  Fly   117 SILLIAITDSD-------C------------PRLPLNRALMVPIVENGDEFPQLILDAKVQQILN 162
            .|::.|.||..       |            |....:..::..|.:..| .|.::.|
  Fly    60 PIVVYANTDDSFIMEKMVCNLISQGVIAIFGPSTGSSSDIIASICDTLD-IPHIVYD-------- 115

  Fly   163 W-------------KTAVVFVDQTILEEN-ALLVKSIVHESITNHITPISLILYEINDSLRGQQK 213
            |             .|..|..|..:|.:. |.:|:|....|.|        ::||.:..|:..|.
  Fly   116 WIPNESIPDREHSTMTLNVHPDNLLLSQGLAEIVQSFAWRSFT--------VVYETDKELQQLQD 172

  Fly   214 RVALRQALS------QFAP--------KKHEEMRQQFLVISAFHEDIIEIAETLN-MFHVGNQWM 263
            .:.:.:.:|      |..|        |:.:......|::....:::::|.:..| :..:|....
  Fly   173 ILQVGEPISNPTTVKQLGPGDDHRPFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQS 237

  Fly   264 IFV--LDMVARDF------DAGTVTINLDEGA-----NIAFALNE----------TDPNCQDS-- 303
            :|:  ||..:.||      :|...|:.|.:.:     |:.....|          .|||...|
  Fly   238 VFIPLLDTHSIDFGELSGVEANITTVRLMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQM 302

  Fly   304 --LNCTISEISLALVNAISKITVEEESIYGEISDEEWEAIRFTKQEKQAEILEYMKEFLKTNAKC 366
              ||..:...|..|.         |..|:.|::..:.|..|.........|:|::|      |:.
  Fly   303 ILLNDAVWLFSKGLT---------ELGIFEELTAPDLECRRKKPWPFGKRIIEFIK------ARS 352

  Fly   367 SSCARWRVETAITWGKSQENRKFRSTPQRDAKNRNF------EFINIGYWTPVLGFVC---QELA 422
            ...:..|::             |....||......|      .|:::..|.||.|...   .|.:
  Fly   353 EETSTGRID-------------FNENGQRSFFTLRFMELNSDGFLDLATWDPVNGLDVLNDDEES 404

  Fly   423 FPHIEHHFRNITMDI--------LTVHNP-PWQILTKNSNGVIVEHKGIVMEIVKELSRALNFSY 478
            ...:.....|.|..:        ||:..| ..:|||.||     .::|..::::.|:::.|||.:
  Fly   405 EKRVGQKLSNKTFIVSSRLGAPFLTLREPQEGEILTGNS-----RYEGYSIDLINEIAKMLNFKF 464

  Fly   479 YLHEASAWKEEDSLSTSAGGNESDELVGSMTFRIPYRVVEMVQGNQFFIAAVAATVEDPDQKPFN 543
                        ....|..|...  .:..:|......|.:::.||. .:.....|:....::..:
  Fly   465 ------------EFRMSPDGKYG--ALNKVTQTWDGIVRQLIDGNA-DLGICDLTMTSSRRQAVD 514

  Fly   544 YTQPISVQKYSFI-TRKPDEVSRIYLFTAPFTVETWFCLMGIILLTAPTLYAINRLA-------- 599
            :|.|......|.: ::.|...:.::.|.:||:::.|..:....|..:..|:|:.|:|
  Fly   515 FTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPH 579

  Fly   600 PLKE-MRIVGLSTVKSCFWYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIVLVTTYCGNLVAFL 663
            |.|| ..:..:.::.:..|...|:|:.||...||.|.|.|||.|.||...::::.:|..||.|||
  Fly   580 PCKEPEEVENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAFL 644

  Fly   664 TFPKFQPGVDYLNQLED--HKDIVQYGLRNG----TFFERYVQSTTREDFKHYLERA--KIYGSA 720
            |..:   ..:.:|..||  .:..::||...|    .|| |....:|.:.....:|.|  .::...
  Fly   645 TNSR---QANSINSAEDLAAQSKIKYGAMAGGSTMGFF-RDSNFSTYQKMWTAMESASPSVFTKT 705

  Fly   721 QEEDIEAVKRGERINIDWRINLQLIVQR----HFEREKECHFAL--GRESFVDEQIAMIVPAQSA 779
            .:|.:|.|::|:        ||...:..    .:..|::|....  |...:....|||  |..|.
  Fly   706 NDEGVERVQKGK--------NLYAFLMESTTLEYNVERKCDLVQIGGWLDYKSYGIAM--PFNSP 760

  Fly   780 YLHLVNRHIKSMFRMGFIER-----WHQMNLPSAGKCNGKSAQRQVTNHKVNMDDMQGCFLVLLL 839
            |...::..:..:..:|.:..     |.:|:  ..|.|. ||.:......::.::::.|.||||.|
  Fly   761 YRKQISAAVLKLGELGQLAELKRKWWKEMH--GGGNCE-KSDEDGGDTPELGLENVGGVFLVLGL 822

  Fly   840 GFTLALLIVCGEF-W 853
            |...|:::.|.|| |
  Fly   823 GLLSAMVLGCTEFLW 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	68/292 (23%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	67/287 (23%)
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	78/425 (18%)
		ANF_receptor	39..379	CDD:279440	69/386 (18%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	88/406 (22%)
		Lig_chan	548..812	CDD:278489	65/280 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462611
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940