DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and gria4b

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_997917.2	Gene:	gria4b / 336069	ZFINID:	ZDB-GENE-030131-8013	Length:	904	Species:	Danio rerio

Alignment Length:	897	Identity:	165/897 - (18%)
Similarity:	329/897 - (36%)	Gaps:	213/897 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 FYKNT-QETSILLIAI----TDSDCPRLPLNRALMVPIVENGDEFPQLILDAKVQQILNWKTAVV 168
            |.:|| ||.:...:||    |..:....|.|....|..:|..:.|  .:.:|...|......|:.
Zfish    33 FIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSF--AVTNAFCSQYSRGVFAIF 95

  Fly   169 FVDQTILEENALLVKSIVHESITN-----HITPI---------SLILYEINDSLRG--------- 210
                      .|..|..|| ::|:     ||:.|         |..:.::..|:||
Zfish    96 ----------GLYDKRSVH-TLTSFCGALHISLITPSFPTEGESQFVLQLRPSIRGALLSLLDHY 149

  Fly   211 ----------QQKRVALRQALSQFAPKKHEEMRQQFLVISAFHE-DIIEIAETLNMFHVGNQWMI 264
                      ..:..::.||:.:.|.:...::  ..:.:..|:: ...::.|.|:.    .|...
Zfish   150 DWNRFVFLYDTDRGYSILQAIMEKAGQNGWQV--SAICVENFNDASYRQLLEDLDR----RQEKT 208

  Fly   265 FVLDMVARDFDAGTVTINLDEG---------------ANIAFALNETDPNCQDSLNCTISEISLA 314
            ||:|:.|...:      |:.|.               ||:.|    .|.|.:..::...:.....
Zfish   209 FVIDLEAERLN------NMLEQIVSVGKHVKGYHYIMANLGF----KDINLERFMHGGANVTGFQ 263

  Fly   315 LVNAISKITVEEESIYGEISDEEW----------------------EAIRFTKQEKQAEILEYMK 357
            ||:..:.:.::....:.::...|:                      ||.|..:::|    ::..:
Zfish   264 LVDFSNPMVIKLMQRWNKLDQREYPGSDAPPKYTSALTYDGVMVMAEAFRNLRRQK----VDISR 324

  Fly   358 EFLKTNAKCSSCARWR----VETAITWGKSQENRKFRSTPQRDAKNRNFEFI------------N 406
            ..:..:...:..|.|.    :|..:   |....:......|.|...|...:.            .
Zfish   325 RGIAGDCLANPAAPWNQGIDMERTL---KQVHLQGLTGNVQFDHYGRRVNYTMDVFELKSNGPRR 386

  Fly   407 IGYWTPV--LGFVCQELAFPHIEHHFRNITMDILTVHNPPWQILTKN-----SNGVIVEHKGIVM 464
            ||||...  |.........|:......|.|:.:.|:...|:.:|.||     .|   .:::|..:
Zfish   387 IGYWNDADKLVLTQDHALLPNETSGMENRTVIVTTIMEGPYVMLKKNWEMYEGN---EQYEGYCV 448

  Fly   465 EIVKELSRALNFSYYLH------------EASAWKEEDSLSTSAGGNESDELVGSMTFRIPYRVV 517
            ::..|:::.:.|.|.:.            |...|               :.:||
Zfish   449 DLASEIAKHIGFKYKISIVPDGKYGARDPETKIW---------------NGMVG----------- 487

  Fly   518 EMVQGNQFFIAAVAATVEDPDQKPFNYTQPISVQKYSFITRKPDEVS-RIYLFTAPFTVETWFCL 581
            |:|.| :..||....|:....::..::::|......|.:.:||.:.. .::.|..|...|.|.|:
Zfish   488 ELVYG-KAEIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCI 551

  Fly   582 MGIILLTAPTLYAINRLAPLK------EMRIVGLST--------VKSCFWYIFGALLQQGGMYLP 632
            :...:..:..|:.::|.:|.:      |....||.:        :.:..|:..||.:|||....|
Zfish   552 VFAYIGVSVVLFLVSRFSPYEWHTEEPEEGTDGLPSDQPPNEFGIFNSLWFSLGAFMQQGCDISP 616

  Fly   633 TADSGRLVVGFWWIVVIVLVTTYCGNLVAFLTFPKFQPGVDYLNQLEDHKDIVQYGLRNGT---F 694
            .:.|||:|.|.||...::::::|..||.||||..:....::....|....||....|.:|:   |
Zfish   617 RSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTDIAYGTLDSGSTKEF 681

  Fly   695 FERYVQSTTREDFKHYLERAK--IYGSAQEEDIEAVKRGERINIDWRINLQLIVQRHFEREKECH 757
            |.| .:....|....|::.|:  ::.....|.:..|::.:.   .:...|:..:..:.|:.|.|.
Zfish   682 FRR-SKIAVYEKMWSYMKSAEPTVFTKTTAEGVARVRKSKG---KYAFLLESTMNEYTEQRKPCD 742

  Fly   758 FALGRESFVDEQIAMIVPAQSAYLHLVNRHIKSMFRMGFIER-----WHQMNLPSAGKC-NGKSA 816
            ......:...:...:..|..|.....||..:..:...|.:::     |:     ..|:| :|...
Zfish   743 TMKVGGNLDSKGYGVATPKGSQLRSAVNLAVLKLNEQGLLDKLKNKWWY-----DKGECGSGGGG 802

  Fly   817 QRQVTNHKVNMDDMQGCFLVLLLGFTLALLIVCGEFWYR-RFRASRKRRQFT 867
            ::..::..:::.::.|.|.:|:.|..||:|:...||.|: |..|.|.:..||
Zfish   803 EKDKSSQALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRNEAKRMKLTFT 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	65/302 (22%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	58/284 (20%)
gria4b	NP_997917.2	Periplasmic_Binding_Protein_Type_1	28..398	CDD:324556	65/400 (16%)
		PBP2_iGluR_AMPA_GluR4	414..793	CDD:270445	81/417 (19%)
		Lig_chan	546..827	CDD:306551	59/289 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591371
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.940