DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and GluRIIC

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster

Alignment Length:	929	Identity:	177/929 - (19%)
Similarity:	312/929 - (33%)	Gaps:	260/929 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 RNGGINV-KYFSWNAVRLKKDFLA---AITVTDCENTWNFYK------------NTQETSILLIA 122
            |...||: .:|..:.:.|:|:|:.   ||...:.|.|..||.            ..||.:..||
  Fly    21 RGQQINIGAFFYDDELELEKEFMTVVNAINGPESEQTMRFYPLIKRLKPEDGSVTMQEHACDLI- 84

  Fly   123 ITDSDCPRL--PLNRAL--MVPIVENGDEFPQLILDAKVQQILNWK-----TAVVFVDQTILEE- 177
              |:....:  |.::|.  :|.:|.|....|.:..|...:.|...|     |..::..|.||.:
  Fly    85 --DNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKPNHQMTLNLYPAQAILSKA 147

  Fly   178 NALLVKSIVHESITNHITPISLILYEINDSLRGQQKRVALR-QALSQFAPKKHEEMRQQFLVISA 241
            .|.:|::......|        |:|:.:|:      |.|.| |.|.|.     .|:....:.:..
  Fly   148 YADIVQNFGWRKFT--------IVYDADDA------RAAARLQDLLQL-----REVHNDVVRVRK 193

  Fly   242 FHED------------------------IIEIAETLNMFHVGNQW-MIFVLDMVARDFDAGTVTI 281
            ||:|                        ::|:..:...|.:..|: .||:.::       .|.|.
  Fly   194 FHKDDDFRVMWKSIRGERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNL-------ETYTD 251

  Fly   282 NLDEGANIAFALNETDPNCQDSLNCTISEISLALVN--------AISKITVEEESIYGE------ 332
            :|:|.|    |.|||     .::|.|.:.:   |||        ....:|..:..:|..
  Fly   252 HLEELA----ADNET-----FAVNITAARL---LVNPDPPPYSLPYGYVTQRDNIVYESSDPPRT 304

  Fly   333 -ISDEEWEAIRFTKQEKQAEILEYMKEFLKTNAKCSSCARWRVETAITWGKSQ------------ 384
             |.|...:|::...|..:.....|....:.....|...|    ....||...:
  Fly   305 LIHDLIHDALQLFAQSWRNASFFYPDRMVVPRITCDFAA----SGGRTWAMGRYLARLMKGTSGV 365

  Fly   385 ENRKFR-STPQRDAKNRNFEF----------INIGYWTPVLGFVCQELAFPHIEHHFRNITMD-- 436
            .|..|| |..|.|...:...|          |.|..|.| .|.:.|             :.:|
  Fly   366 NNTNFRTSILQFDEDGQRITFNIEVYDPLDGIGIAIWDP-RGQITQ-------------LNVDVK 416

  Fly   437 --------ILTVHNPPW-------QILTKNSNGVIVEHKGIVMEIVKELSRALNFSYYL------ 480
                    :.|...||:       :.|....|.:   ::|..::::..::|.:.|.|..
  Fly   417 AQKKMIYRVATRIGPPYFSYNETARELNLTGNAL---YQGYAVDLIDAIARHVGFEYVFVPVADQ 478

  Fly   481 ------HEASAWKEEDSLSTSAGGNESDELVGSMTFRIPYRVVEMVQGNQFFIAAVAATVEDPDQ 539
                  .|...|               :.::|.            :..|...:.....|:....:
  Fly   479 QYGKLDKETKQW---------------NGIIGE------------IINNDAHMGICDLTITQARK 516

  Fly   540 KPFNYTQPISVQKYSFITRKPDEVSR-IYLFTAPFTVETW-FCLMGIILLT-APTLYA------- 594
            ...::|.|......|.:..|...|.: :..:.|||..|.| :.|:.:.::| ..|:.|
  Fly   517 TAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDW 581

  Fly   595 -----INRLAPLKEMRIVGLSTVKSCFWYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIVLVTT 654
                 .||...:.|.:    ..:.:..|....:::..|...||.:...|:....|||..|::..:
  Fly   582 ENPHPCNRDPEVLENQ----WRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANS 642

  Fly   655 YCGNLVAFLTFPKFQPGVDYLNQLEDHKDIVQYGL------------RNGTFFERYVQSTTREDF 707
            |..||.||||..|.:..:..|..|...|. |::|.            .|.|.:.........:|.
  Fly   643 YTANLAAFLTSSKMEGSIANLKDLSAQKK-VKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDP 706

  Fly   708 KHYLERAKIYGSAQEEDIEAVKRGERINIDWRINLQLIVQRHFEREKECHFALGRESFVDEQIAM 772
            ..|          .::::|.|.|..:...|:.. |.......:.||:.|......|.|.::..|:
  Fly   707 SAY----------TKDNLEGVDRVRKNRGDYMF-LMETTTLEYHREQNCDLRSVGEKFGEKHYAI 760

  Fly   773 IVPAQSAYLHLVNRHIKSMFRMGFI----ERWHQMNLPSAGKCNGKSAQRQVTNHKVNMDDMQGC 833
            .||..:.|...::..|..:...|.:    ::|.:....|..:.....|...:|     .::::|.
  Fly   761 AVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPDMT-----FEELRGI 820

  Fly   834 FLVLLLGFTLALLIVCGEF 852
            |..|..|..:|.||...||
  Fly   821 FYTLYAGILIAFLIGITEF 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	56/323 (17%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	57/289 (20%)
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	85/422 (20%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	11/87 (13%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	74/416 (18%)
		Lig_chan	554..828	CDD:278489	58/294 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462613
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940