DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and Grik3

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_001106187.1	Gene:	Grik3 / 298521	RGDID:	71027	Length:	919	Species:	Rattus norvegicus

Alignment Length:	880	Identity:	179/880 - (20%)
Similarity:	335/880 - (38%)	Gaps:	179/880 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 FSWNAVRLKKDFLAAITVTDCENTWNFYKNTQET-------SILLIAI---TDSDCPRL--PLNR 135
            ||.|.:...:..|...|:|......:|:.:.:.|       ::.::||   :...|...  .:..
  Rat    62 FSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICN 126

  Fly   136 ALMVPIV---------ENGDEF-----------PQLILDAKVQQILNWKTA-VVFVDQTILEENA 179
            ||.||.:         :|.|.|           ...|||  :.|.|.|::| ||:.|.|.|   .
  Rat   127 ALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILD--LVQSLKWRSATVVYDDSTGL---I 186

  Fly   180 LLVKSIVHESITNHITPISLILYEINDSLRGQQKRVALRQALSQFAPKKHEEMRQQFLVISAFHE 244
            .|.:.|:..|..|....|..:..:.:||          |..|.:.  |:..|.|..|........
  Rat   187 RLQELIMAPSRYNIRLKIRQLPIDSDDS----------RPLLKEM--KRGREFRIIFDCSHTMAA 239

  Fly   245 DIIEIAETLNMFHVGNQWMIFVLDMVARDFD---------AGTVTINLDEGANIAFALN------ 294
            .|::.|..:.|......::...||:.|.|.:         .|...:|:|.....|....
  Rat   240 QILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERL 304

  Fly   295 ETDPNCQDSLNCTISEISLALV-NAISKITV----EEESIYGEISDEEWEAIRFTKQEKQAEILE 354
            :..|..:..|...:.....||: :|:..::|    ..:.....:.....:|.||     ....:.
  Rat   305 QAAPRAESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRF-----GGRFMN 364

  Fly   355 YMKEFLKTNAKCSSCARWRVETA-ITWGKSQENRKFRSTPQRDAKNRNFEFINIGYWTPVLGFVC 418
            ::||           |:|...|. |.:.|:...|..........|....|  .:|.|:|..|...
  Rat   365 FIKE-----------AQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLE--KVGVWSPADGLNI 416

  Fly   419 QELA---FPHIEHHFRNITMDILTVHNPPWQILTKNSNGVIVEHK--GIVMEIVKELSRALNFSY 478
            .|:|   .|::.....|.::.:.|:...|:.:..|:...:....:  |..::::|||:..|.|||
  Rat   417 TEVAKGRGPNVTDSLTNRSLIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSY 481

  Fly   479 YLH--EASAWKEEDSLSTSAGGNESDELVGSMTFRIPYRVVEMVQGNQFFIAAVAATVEDPDQKP 541
            .:.  |...:..:|......|                 .|.|::. ::..:|....|:....:|.
  Rat   482 EIRLVEDGKYGAQDDKGQWNG-----------------MVKELID-HKADLAVAPLTITHVREKA 528

  Fly   542 FNYTQPISVQKYSFITRKPDEVS-RIYLFTAPFTVETWFCLMGIILLTAPTLYAINRLAPLK--- 602
            .::::|......|.:.|||:..: .::.|..|.:.:.|..::...|..:..|:.|.|.:|.:
  Rat   529 IDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYD 593

  Fly   603 --------EMRIVGLSTVKSCFWYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIVLVTTYCGNL 659
                    |: :....|:.:.||:..|:|:|||...:|.|.|.|::.|.||...::::::|..||
  Rat   594 AHPCNPGSEV-VENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANL 657

  Fly   660 VAFLTFPKFQPGVDYLNQLEDHKDIVQYG-LRNG---TFFERYVQSTTREDFKHYLERAKIYGSA 720
            .||||..:.:..:|..:.|.....| :|| :::|   |||::...||..:.:.....:.......
  Rat   658 AAFLTVERMESPIDSADDLAKQTKI-EYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKN 721

  Fly   721 QEEDIEAVKRGERINIDWRINLQLIVQRHFEREKECHFA-LGRESFVDEQ--------------- 769
            .||.|:.....:...:.....::.|.||:      |:.. :|  ..:|.:
  Rat   722 NEEGIQRTLTADYALLMESTTIEYITQRN------CNLTQIG--GLIDSKGYGIGTPMGSPYRDK 778

  Fly   770 --IAMIVPAQSAYLHLVNRHIKSMFRMGFIERWHQMNLPSAGKCNGKSAQRQVTNHKVNMDDMQG 832
              ||::...:...||::.            |:|        .:.:|...:.......:.:..:.|
  Rat   779 ITIAILQLQEEDKLHIMK------------EKW--------WRGSGCPEEENKEASALGIQKIGG 823

  Fly   833 CFLVLLLGFTLALLIVCGEFWYR-RFRASRKRRQF 866
            .|:||..|..|::|:..|||.|: |..|.|::|.|
  Rat   824 IFIVLAAGLVLSVLVAVGEFIYKLRKTAEREQRSF 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	65/287 (23%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	58/292 (20%)
Grik3	NP_001106187.1	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	77/389 (20%)
		ANF_receptor	55..398	CDD:279440	71/368 (19%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	82/415 (20%)
		Lig_chan	564..832	CDD:278489	60/297 (20%)
		Glutamate binding	690..692		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349919
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840