Protein Alignment Ir93a and GRIN2D

DIOPT Version :9

• Sequence 1: NP_650924.3
• Gene: Ir93a / 42471
• FlyBaseID: FBgn0259215
• Length: 868
• Species: Drosophila melanogaster
• Sequence 2: NP_000827.2
• Gene: GRIN2D / 2906
• HGNCID: 4588
• Length: 1336
• Species: Homo sapiens
• Alignment Length: 424
• Identity: 85/424 - (20%)
• Similarity: 178/424 - (41%)
• Gaps: 61/424 - (14%)

  Fly   460 KGIVMEIVKELSRALNFSYYLHEASAWKEEDSLSTSAGGNESDELVGSMTFRIPYRVVEMVQGNQ 524
            ||..::|:|.|:..:.|||.|:..:..|.         |.:.|.:...|...:.|:..:|..|
Human   485 KGFCIDILKRLAHTIGFSYDLYLVTNGKH---------GKKIDGVWNGMIGEVFYQRADMAIG-- 538

  Fly   525 FFIAAVAATVEDPDQKPFNYTQPISVQKYSFITRKPDEVSRIYLFTAPFTVETWFCLMGIILLT- 588
                  :.|:.:...:..:::.|......|.:..:.:.......|..|::...| .:|.::.||
Human   539 ------SLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVW-VMMFVMCLTV 596

  Fly   589 -APTLYAINRLAPLKEMRIVGLS--------TVKSCFWYIFGALLQQGGMYL--PTADSGRLVVG 642
             |.|::....|:|:...|.:...        |:....|.:: ||:....:.:  |...:.:::|.
Human   597 VAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLW-ALVFNNSVPVENPRGTTSKIMVL 660

  Fly   643 FWWIVVIVLVTTYCGNLVAFLTFPKFQPGVDYLNQLEDHK--------DIVQYG-LRNGTFFERY 698
            .|....::.:.:|..||.||:...::   ||.::.|.|.|        ..:::| :.||: .|:.
Human   661 VWAFFAVIFLASYTANLAAFMIQEEY---VDTVSGLSDRKFQRPQEQYPPLKFGTVPNGS-TEKN 721

  Fly   699 VQSTTREDFKHYLERAKIYGSAQ-EEDIEAVKRGERINIDWRINLQLIVQRHFEREKECHF-ALG 761
            ::| ...|...|:.|   |...: ||.:..:|.|:   :|..|....::.....:::.|.. .:|
Human   722 IRS-NYPDMHSYMVR---YNQPRVEEALTQLKAGK---LDAFIYDAAVLNYMARKDEGCKLVTIG 779

  Fly   762 R-ESFVDEQIAMIVPAQSAYLHLVNRHIKSMFRMGFIERWHQMNLPSAGKCNGKSAQRQVTNHKV 825
            . :.|......:.:...|.:...::..:........||...::.|  :|.|:....  :|.:.|:
Human   780 SGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWL--SGICHNDKI--EVMSSKL 840

  Fly   826 NMDDMQGCFLVLLLGFTLALLIVCGE---FWYRR 856
            ::|:|.|.|.:||:...|:||:...|   :|..|
Human   841 DIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLR 874

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	50/257 (19%)
		Lig_chan	576..836	CDD:306551	56/283 (20%)
GRIN2D	NP_000827.2	PBP1_iGluR_NMDA_NR2	49..413	CDD:380601
		PBP2_iGluR_NMDA_Nr2	430..830	CDD:270436	71/376 (19%)
		Glutamate binding. /evidence=ECO:0000250|UniProtKB:Q00959	539..541		0/1 (0%)
		Pore-forming. /evidence=ECO:0000250|UniProtKB:Q00960	631..650		3/19 (16%)
		Glutamate binding. /evidence=ECO:0000250|UniProtKB:Q00959	717..718		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	900..934
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	981..1123
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1225..1336
		PDZ-binding. /evidence=ECO:0000250	1334..1336

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155996
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840