DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir93a and GRIK4

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_001269399.1	Gene:	GRIK4 / 2900	HGNCID:	4582	Length:	956	Species:	Homo sapiens

Alignment Length:	922	Identity:	176/922 - (19%)
Similarity:	345/922 - (37%)	Gaps:	237/922 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EMRPSACLLLLAGLQLSILVPTEANDFSSFLSANASLAVVVDHEYMTVHGENILAHFEKILSDVI 69
            |...:.|.:|..|: :::|.|:.:...||.:|              .:.||..:.||:....:.:
Human    78 ETAETMCQILPKGV-VAVLGPSSSPASSSIIS--------------NICGEKEVPHFKVAPEEFV 127

  Fly    70 RENLRNGGINVKYFSWNAVRLKKDFLAAITVTDCENTWNFYKNTQETSILLIAITDSDCPRLPLN 134
            :...:      ::.:.|......|...|:.     ...||:..|  |:.|:.|  .::| .|.|.
Human   128 KFQFQ------RFTTLNLHPSNTDISVAVA-----GILNFFNCT--TACLICA--KAEC-LLNLE 176

  Fly   135 RALMVPIVENGDEFPQLILDAK-----VQQILNWKTAVVFVDQTILEENALLVKSIVHESITNHI 194
            :.|...::.......:::.|.:     :::|.:.|||.:.:.......:.:|:|:.....::.:.
Human   177 KLLRQFLISKDTLSVRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYY 241

  Fly   195 TPISLILYEINDSLRGQQKRVALRQALSQFAPKKHEEMRQQFLVISAFHEDIIEIAETLNMFHVG 259
            |   .|...:..||:.....|..|..:..|:            :.:..|....|.|::||
Human   242 T---YIFTNLEFSLQRMDSLVDDRVNILGFS------------IFNQSHAFFQEFAQSLN----- 286

  Fly   260 NQWMIFVLDMVARDFDAGTVTINLDEGANIAFALNETDPNCQDSLNCTISEISLALVNAISKITV 324
            ..|.                 .|.|   ::.|    |.|....:|   :.:...|:|.|:.::..
Human   287 QSWQ-----------------ENCD---HVPF----TGPALSSAL---LFDAVYAVVTAVQELNR 324

  Fly   325 EEESIYGEISDEEWEAIRFTKQEKQAEILEYMKEFLKTNAKCSSCARWRVETAI-TWGKSQE--- 385
            .:|.....:|                               |.|...|:..|:: .:.:..|
Human   325 SQEIGVKPLS-------------------------------CGSAQIWQHGTSLMNYLRMVELEG 358

  Fly   386 ---NRKFRSTPQRD-------AKNRNFEFINIGYWTPVLGF-VCQELAFPHIEHHFRNITMDILT 439
               :.:|.|..||.       ...|| .|..||.|....|. :...|...:|.....|.|:.:.|
Human   359 LTGHIEFNSKGQRSNYALKILQFTRN-GFRQIGQWHVAEGLSMDSHLYASNISDTLFNTTLVVTT 422

  Fly   440 VHNPPWQILTKN-----SNGVIVEHKGIVMEIVKELSRALNFSYYLHEASAWKEEDSLSTSAGGN 499
            :...|:.:|..|     .|.   .::|..::::|||:..|.|:|.:
Human   423 ILENPYLMLKGNHQEMEGND---RYEGFCVDMLKELAEILRFNYKI------------------- 465

  Fly   500 ESDELVGSMTFRIPY-------RVVEMVQGNQFFIAAVAATVEDPDQKPFNYTQP-----ISVQK 552
               .|||...:.:|.       .|.|:: ..:..:|....|:....:|..::::|     ||:..
Human   466 ---RLVGDGVYGVPEANGTWTGMVGELI-ARKADLAVAGLTITAEREKVIDFSKPFMTLGISILY 526

  Fly   553 YSFITRKPDEVSRIYLFTAPFTVETWFCLMGIILLTAPTLYAINRLAPLKEMR-----------I 606
            ...:.|||...|    |..||:...|..::...|..:..|:.:.||.|.:...           :
Human   527 RVHMGRKPGYFS----FLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLL 587

  Fly   607 VGLSTVKSCFWYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIVLVTTYCGNLVAFLTFPKFQPG 671
            |...::.:..|:..|..:|||....|.|.|.|.|.|.||...::::::|..||.||||..:....
Human   588 VNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVP 652

  Fly   672 VDYLNQLEDHKDIVQYGLRNG----TFFERYVQSTTREDFKH-YLERAKIYGSAQEEDIEAVKRG 731
            ::.::.|.| :..::||..:|    |||:.....|.:..:.: |.::..::..:.||.|..|
Human   653 IESVDDLAD-QTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARV--- 713

  Fly   732 ERINIDWRINLQLIVQRHFEREKECH------------FALGR---ESFVDE-QIAMIVPAQSAY 780
              :|.::...|:..:..:: |::.|:            :.:|.   ..|.|| .:|::...::..
Human   714 --LNSNYAFLLESTMNEYY-RQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNR 775

  Fly   781 LHLVNRHIKSMFRMGFIERWHQMNLPSAGKCNGKSAQRQVTNHKVNMDDMQGCFLVLLLGFTLAL 845
            |.::.|            :|.:     .|||..:...|.   ..:.|:::.|.|:||:.|..:|:
Human   776 LEILKR------------KWWE-----GGKCPKEEDHRA---KGLGMENIGGIFVVLICGLIVAI 820

  Fly   846 LIVCGEF-WYRR 856
            .:...|| |..|
Human   821 FMAMLEFLWTLR 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	68/299 (23%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	60/291 (21%)
GRIK4	NP_001269399.1	PBP1_iGluR_Kainate_KA1_2	26..400	CDD:107389	73/431 (17%)
		ANF_receptor	43..382	CDD:279440	66/412 (16%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	86/418 (21%)
		Lig_chan	547..816	CDD:278489	62/295 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..889
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155766
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940