DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and GRIK3

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_000822.2	Gene:	GRIK3 / 2899	HGNCID:	4581	Length:	919	Species:	Homo sapiens

Alignment Length:	886	Identity:	180/886 - (20%)
Similarity:	336/886 - (37%)	Gaps:	191/886 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 FSWNAVRLKKDFLAAITVTDCENTWNFYKNTQET-------SILLIAI---TDSDCPRL--PLNR 135
            ||.|.:...:..|...|:|......:|:.:.:.|       ::.::||   :...|...  .:..
Human    62 FSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICN 126

  Fly   136 ALMVPIV---------ENGDEF-----------PQLILDAKVQQILNWKTA-VVFVDQTILEENA 179
            ||.||.:         :|.|.|           ...|||  :.|.|.|::| ||:.|.|.|   .
Human   127 ALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILD--LVQYLKWRSATVVYDDSTGL---I 186

  Fly   180 LLVKSIVHESITNHITPISLILYEINDSLRGQQKRVALRQALSQFAPKKHEEMRQQFLVISAFHE 244
            .|.:.|:..|..|....|..:..:.:||          |..|.:.  |:..|.|..|........
Human   187 RLQELIMAPSRYNIRLKIRQLPIDSDDS----------RPLLKEM--KRGREFRIIFDCSHTMAA 239

  Fly   245 DIIEIAETLNMFHVGNQWMIFVLDMVARDFD---------AGTVTINLDEGANIAF--------- 291
            .|::.|..:.|......::...||:.|.|.:         .|...:|:|.....|.
Human   240 QILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERL 304

  Fly   292 -ALNETDPNCQDSLNCTISEISLALVNAIS-------KITVEEESIYGEISDEEWEAIRFTKQEK 348
             |...::....|.:..|.:.:....|:.:|       ::||      ..:.....:|.||
Human   305 QAAPRSESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTV------NSLQCHRHKAWRF----- 358

  Fly   349 QAEILEYMKEFLKTNAKCSSCARWRVETA-ITWGKSQENRKFRSTPQRDAKNRNFEFINIGYWTP 412
            ....:.::||           |:|...|. |.:.|:...|..........|....|  .:|.|:|
Human   359 GGRFMNFIKE-----------AQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLE--KVGVWSP 410

  Fly   413 VLGFVCQELA---FPHIEHHFRNITMDILTVHNPPWQILTKNSNGVIVEHK--GIVMEIVKELSR 472
            ..|....|:|   .|::.....|.::.:.||...|:.:..|:...:....:  |..::::|||:.
Human   411 ADGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAH 475

  Fly   473 ALNFSYYLH--EASAWKEEDSLSTSAGGNESDELVGSMTFRIPYRVVEMVQGNQFFIAAVAATVE 535
            .|.|||.:.  |...:..:|......|                 .|.|::. ::..:|....|:.
Human   476 ILGFSYEIRLVEDGKYGAQDDKGQWNG-----------------MVKELID-HKADLAVAPLTIT 522

  Fly   536 DPDQKPFNYTQPISVQKYSFITRKPDEVS-RIYLFTAPFTVETWFCLMGIILLTAPTLYAINRLA 599
            ...:|..::::|......|.:.|||:..: .::.|..|.:.:.|..::...|..:..|:.|.|.:
Human   523 HVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFS 587

  Fly   600 PLK-----------EMRIVGLSTVKSCFWYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIVLVT 653
            |.:           |: :....|:.:.||:..|:|:|||...:|.|.|.|::.|.||...:::::
Human   588 PYEWYDAHPCNPGSEV-VENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIIS 651

  Fly   654 TYCGNLVAFLTFPKFQPGVDYLNQLEDHKDIVQYG-LRNG---TFFERYVQSTTREDFKHYLERA 714
            :|..||.||||..:.:..:|..:.|.....| :|| :::|   |||::...||..:.:.....:.
Human   652 SYTANLAAFLTVERMESPIDSADDLAKQTKI-EYGAVKDGATMTFFKKSKISTFEKMWAFMSSKP 715

  Fly   715 KIYGSAQEEDIEAVKRGERINIDWRINLQLIVQRHFEREKECHFA-LGRESFVDEQ--------- 769
            .......||.|:.....:...:.....::.:.||:      |:.. :|  ..:|.:
Human   716 SALVKNNEEGIQRALTADYALLMESTTIEYVTQRN------CNLTQIG--GLIDSKGYGIGTPMG 772

  Fly   770 --------IAMIVPAQSAYLHLVNRHIKSMFRMGFIERWHQMNLPSAGKCNGKSAQRQVTNHKVN 826
                    ||::...:...||::.            |:|        .:.:|...:.......:.
Human   773 SPYRDKITIAILQLQEEDKLHIMK------------EKW--------WRGSGCPEEENKEASALG 817

  Fly   827 MDDMQGCFLVLLLGFTLALLIVCGEFWYR-RFRASRKRRQF 866
            :..:.|.|:||..|..|::|:..|||.|: |..|.|::|.|
Human   818 IQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAEREQRSF 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	66/287 (23%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	57/292 (20%)
GRIK3	NP_000822.2	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	78/395 (20%)
		ANF_receptor	55..398	CDD:279440	72/374 (19%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	82/415 (20%)
		Lig_chan	564..832	CDD:278489	59/297 (20%)
		Glutamate binding. /evidence=ECO:0000250	690..692		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156000
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840