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Protein Alignment Ir93a and GRIK2

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_068775.1	Gene:	GRIK2 / 2898	HGNCID:	4580	Length:	908	Species:	Homo sapiens

Alignment Length:	924	Identity:	189/924 - (20%)
Similarity:	350/924 - (37%)	Gaps:	232/924 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 LRNGGINVKY--------------FSWNAVRLKKDFLAAITVTDCENTWNFY-------KNTQET 116
            ||.||| .:|              |:.|.:...:..|...|:|......|.|       |...:.
Human    36 LRFGGI-FEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQL 99

  Fly   117 SILLIAI-----------TDSDCPRLPLNRALMVP---------IVENGDEF-----------PQ 150
            |:.:.||           ..|.|      .||.||         :.:|.|.|           .:
Human   100 SLGVAAIFGPSHSSSANAVQSIC------NALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSR 158

  Fly   151 LILDAKVQQILNWKT-AVVFVDQTILEENALLVKSIVHESITNHITPISLILYEINDSLRGQQKR 214
            .|||  :.|...||| .||:.|.|.|.....|:|:....::                       |
Human   159 AILD--LVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNL-----------------------R 198

  Fly   215 VALRQ--ALSQFAPKKHEEMR--QQFLVI-SAFHE---DIIEIAETLNMFHVGNQWMIFVLDMVA 271
            :.:||  |.::.|....:||:  ::|.|| ...||   .|::.|..:.|......::...||:.|
Human   199 LKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFA 263

  Fly   272 RDFDAGTVTINLDEGANI-AFALNETDPNCQDSLNCTISEISLALVNAISK---------ITVEE 326
            .|.:....:     |.|: .|.:..|: |.|  ::..|.:.|:..:.|..|         :|.:.
Human   264 LDVEPYRYS-----GVNMTGFRILNTE-NTQ--VSSIIEKWSMERLQAPPKPDSGLLDGFMTTDA 320

  Fly   327 ESIYGEISDEEWEAIRFTKQEKQAEILEYMKEFLKTNAKCSSCARWRVET--------------- 376
            ..:|        :|:...     :..::...:...::.:|:....||..|
Human   321 ALMY--------DAVHVV-----SVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLT 372

  Fly   377 -AITWGKSQENRKFRSTPQRDAKNRNFEFINIGYWTPVLGF---VCQELAFPHIEHHFRNITMDI 437
             .||:.|:...|..........|....|  .||.|.|..|.   ..|:....:|.....|.::.:
Human   373 GRITFNKTNGLRTDFDLDVISLKEEGLE--KIGTWDPASGLNMTESQKGKPANITDSLSNRSLIV 435

  Fly   438 LTVHNPPWQILTKNSNGVIV---EHKGIVMEIVKELSRALNFSYYLH--EASAWKEEDSLSTSAG 497
            .|:...|: :|.|.|:..:.   ..:|..:::::|||..|.|:|.:.  |...:..:|..:....
Human   436 TTILEEPY-VLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWN 499

  Fly   498 GNESDELVGSMTFRIPYRVVEMVQGNQFFIAAVAATVEDPDQKPFNYTQPISVQKYSFITRKPDE 562
            |                .|.|::. ::..:|.....:....:|..::::|......|.:.|||:.
Human   500 G----------------MVRELID-HKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNG 547

  Fly   563 VS-RIYLFTAPFTVETWFCLMGIILLTAPTLYAINRLAPLK---------EMRIVGLS-TVKSCF 616
            .: .::.|..|.:.:.|..::...|..:..|:.|.|.:|.:         :..:|..: |:.:.|
Human   548 TNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSF 612

  Fly   617 WYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIVLVTTYCGNLVAFLTFPKFQPGVDYLNQLEDH 681
            |:..|||:|||...:|.|.|.|:|.|.||...::::::|..||.||||..:.:..:|..:.|...
Human   613 WFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQ 677

  Fly   682 KDIVQYG-LRNG---TFFERYVQSTTREDFKHYLERAK-IYGSAQEEDIEAVKRGERINIDWRIN 741
            ..| :|| :.:|   |||::...||..:.:.....|.: :...:.||.|:.|...:...:.....
Human   678 TKI-EYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTT 741

  Fly   742 LQLIVQRHFEREKECHFA-LGRESFVDEQ-----------------IAMIVPAQSAYLHLVNRHI 788
            ::.:.||:      |:.. :|  ..:|.:                 ||::...:...||::.
Human   742 IEFVTQRN------CNLTQIG--GLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMK--- 795

  Fly   789 KSMFRMGFIERWHQMNLPSAGKCNGKSAQRQVTNHKVNMDDMQGCFLVLLLGFTLALLIVCGEFW 853
                     |:|        .:.||...:.......:.:.::.|.|:||..|..|::.:..|||.
Human   796 ---------EKW--------WRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFL 843

  Fly   854 YR-RFRASRKRRQF 866
            |: :..|..::|.|
Human   844 YKSKKNAQLEKRSF 857

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.