Protein Alignment Ir93a and GRID2

DIOPT Version :9

• Sequence 1: NP_650924.3
• Gene: Ir93a / 42471
• FlyBaseID: FBgn0259215
• Length: 868
• Species: Drosophila melanogaster
• Sequence 2: XP_011530195.2
• Gene: GRID2 / 2895
• HGNCID: 4576
• Length: 1035
• Species: Homo sapiens
• Alignment Length: 875
• Identity: 171/875 - (19%)
• Similarity: 332/875 - (37%)
• Gaps: 185/875 - (21%)

  Fly    90 LKKDFLAAITVTDCENTWNFYKNTQETSI--LLIAITDSDCPR--LPLNRALMVPIVENGDEF-- 148
            :.:..||.::...|.:..:.........|  |.|..:.:..||  ..|.|:      ...|::
Human    98 MNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRS------NRNDDYTL 156

  Fly   149 ---PQLILDAKVQQILN---WKTAVVFVD--------QTILEENALLVKSIVHESITNHITPISL 199
               |.:.|...:.:::.   |:..::|.|        |..|::.:.....:..:.:.|:|..:..
Human   157 SVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNINKMIT 221

  Fly   200 ILYEINDSLRGQQ---KRVALRQALSQFAPKKHEEMRQQFLVISAFHEDIIEIAETLNMFHVGNQ 261
            .|:   |::|.::   .|..||:|:....|...:..             |.|:.|| |:......
Human   222 TLF---DTMRIEELNRYRDTLRRAILVMNPATAKSF-------------ITEVVET-NLVAFDCH 269

  Fly   262 WMIF--------VLDMVARDFDAGTVTI---------NLDE---GANIAFALNETDPNCQDSLNC 306
            |:|.        |.::|.|..  |.:||         |:.:   ..|...:....||....:.|.
Human   270 WIIINEEINDVDVQELVRRSI--GRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNM 332

  Fly   307 TISEI-----SLALVNAISKITVEEESIYGEISDEEWEAIRFTKQEKQAEILEYMKEFLKTNAKC 366
            .||.:     .|.|.||..|          ::.|.:|.::        |.:     ..::.|:|.
Human   333 EISNLYIYDTVLLLANAFHK----------KLEDRKWHSM--------ASL-----SCIRKNSKP 374

  Fly   367 SSCARWRVETAITWGKSQENRKFRSTPQRDAKNRNFEFI-------------------------- 405
            ....|..:||....|.|....:..........|.:||.:
Human   375 WQGGRSMLETIKKGGVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKNERIRPQGSTGK 439

  Fly   406 ---NIGYWTPVLGFVCQELAFPHIEHHFRNITMDILTVHNPPWQILTKNSNGVIVEHKGIVMEIV 467
               .:|.|.||.| :...|....:|::.|.:.:.::||...|:.::::|..|...:::|..::::
Human   440 IWPQLGCWNPVTG-LNGSLTDKKLENNMRGVVLRVVTVLEEPFVMVSENVLGKPKKYQGFSIDVL 503

  Fly   468 KELSRALNFSYYLHEASAWK----EEDSLSTSAGGNESDELVGSMTFRIPYRVVEMVQGNQFFIA 528
            ..||..|.|:|.::.|...|    :||  .|..|      |||.:.|:            :..|.
Human   504 DALSNYLGFNYEIYVAPDHKYGSPQED--GTWNG------LVGELVFK------------RADIG 548

  Fly   529 AVAATVEDPDQKPFNYTQPISVQKYSFITRKPDEVSRIYLFTAPFTVETWFCLMGIILLTAPTLY 593
            ..|.|:....:...::|..........:.|:.::...::...|||.:..|.|:.|.:||....:|
Human   549 ISALTITPDRENVVDFTTRYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVY 613

  Fly   594 AINRLAPLK-EMRIVGLSTVKSCFWYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIVLVTTYCG 657
            .:|.|.|.: :|..:..:|:.:..|:::|:.:||||....|..:.|:::|.||:..::::::|..
Human   614 LLNWLNPPRLQMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTA 678

  Fly   658 NLVAFLTFPKFQPGVDYLNQLEDHKDIVQYGLRNGTFFERYVQSTTREDFKHYLERAKIY----- 717
            ||.||||..:.:..:..|..|....:|..     ||..:..|....|....:..||..:|
Human   679 NLAAFLTITRIESSIQSLQDLSKQTEIPY-----GTVLDSAVYEHVRMKGLNPFERDSMYSQMWR 738

  Fly   718 ------GS-----AQEEDIEAVKRGERINIDWRINLQLIVQRHFEREKECHFALGRESFVDEQIA 771
                  ||     ..:..|:.||.|....: |.   ..:::.....:.:|.|.....:..|....
Human   739 MINRSNGSENNVLESQAGIQKVKYGNYAFV-WD---AAVLEYVAINDPDCSFYTIGNTVADRGYG 799

  Fly   772 MIVPAQSAYLHLVNRHIKSMFRMGFIE----RWHQMNLPSAGKCN-GKSAQRQVTNHKVNMDDMQ 831
            :.:...|.|..:.::.|..:.:.|.::    :|    .|..|:|: ..|...:.....:::....
Human   800 IALQHGSPYRDVFSQRILELQQNGDMDILKHKW----WPKNGQCDLYSSVDTKQKGGALDIKSFA 860

  Fly   832 GCFLVLLLGFTLALLIVCGEFWYRRFRASR 861
            |.|.:|..|..|:..|...|.|:.:.:.||
Human   861 GVFCILAAGIVLSCFIAMLETWWNKRKGSR 890

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	64/272 (24%)
		Lig_chan	576..836	CDD:306551	60/281 (21%)
GRID2	XP_011530195.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155990
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840