back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and GRIA4

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_000820.4	Gene:	GRIA4 / 2893	HGNCID:	4574	Length:	902	Species:	Homo sapiens

Alignment Length:	916	Identity:	167/916 - (18%)
Similarity:	318/916 - (34%)	Gaps:	255/916 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 FYKNT-QETSILLIAI----TDSDCPRLPLNRALMVPIVENGDEF-------------------- 148
            |.:|| ||.:...:||    |..:....|.|....|..:|..:.|
Human    33 FIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGL 97

  Fly   149 ----------------------PQLILDAKVQQIL-----------------NWKTAVVFVDQTI 174
                                  |....:.:.|.:|                 .|...|...|
Human    98 YDKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLRPSLRGALLSLLDHYEWNCFVFLYD--- 159

  Fly   175 LEENALLVKSIVHESITN--HITPISLILYEINDSLRGQQKRVALRQALSQFAPKKHE------- 230
            .:....::::|:.::..|  |::  ::.:...||        |:.||.|.:...::.:
Human   160 TDRGYSILQAIMEKAGQNGWHVS--AICVENFND--------VSYRQLLEELDRRQEKKFVIDCE 214

  Fly   231 -EMRQQFLVISAFHEDIIEIAETLNMFHVGNQWMIFVLDMVARDFDAGTVTINLDE----GANI- 289
             |..|..|      |.|:.:.:.:..:|.          ::|   :.|...|:|:.    |||:
Human   215 IERLQNIL------EQIVSVGKHVKGYHY----------IIA---NLGFKDISLERFIHGGANVT 260

  Fly   290 AFALNETDPNCQDSLNCTISEISLALVNAISKITVEEESIYGEISDEEWEAIRFTKQEKQAEI-- 352
            .|.|  .|.|         :.:.:.|::...|:. :.|....|...:...|:.:......||.
Human   261 GFQL--VDFN---------TPMVIKLMDRWKKLD-QREYPGSETPPKYTSALTYDGVLVMAETFR 313

  Fly   353 -LEYMKEFLKTNAKCSSCARWRVETAITWGKSQENRKFRSTPQRDAKNRNFEF------IN---- 406
             |...|..:........|.   ...|..||:..:..:.....:......|.:|      :|
Human   314 SLRRQKIDISRRGNAGDCL---ANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMD 375

  Fly   407 -----------IGYW-----------TPVLGFVCQELAFPHIEHHFRNITMDILTVHNPPWQILT 449
                       :|||           .|.||   .:.|      ...|.|:.:.|:...|:.:..
Human   376 VFELKSTGPRKVGYWNDMDKLVLIQDVPTLG---NDTA------AIENRTVVVTTIMESPYVMYK 431

  Fly   450 KN-----SNGVIVEHKGIVMEIVKELSRALNFSYYLHEASAWKEEDSLSTSAGGNESD-ELVGSM 508
            ||     .|.   :::|..:::..|:::.:...|.:......|        .|..::| ::...|
Human   432 KNHEMFEGND---KYEGYCVDLASEIAKHIGIKYKIAIVPDGK--------YGARDADTKIWNGM 485

  Fly   509 TFRIPYRVVEMVQGNQFFIAAVAATVEDPDQKPFNYTQPISVQKYSFITRKPDEVS-RIYLFTAP 572
            ...:.|...|        ||....|:....::..::::|......|.:.:||.:.. .::.|..|
Human   486 VGELVYGKAE--------IAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDP 542

  Fly   573 FTVETWFCLMGIILLTAPTLYAINRLAPL----------KEMRIVGLST-------VKSCFWYIF 620
            ...|.|.|::...:..:..|:.::|.:|.          ||    |.|.       :.:..|:..
Human   543 LAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKE----GPSDQPPNEFGIFNSLWFSL 603

  Fly   621 GALLQQGGMYLPTADSGRLVVGFWWIVVIVLVTTYCGNLVAFLTFPKFQPGVDYLNQLEDHKDIV 685
            ||.:|||....|.:.|||:|.|.||...::::::|..||.||||..:....::....|....:|.
Human   604 GAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIA 668

  Fly   686 QYGLRNGTFFERYVQSTTREDFKHYLERAKI--------YGSAQEEDI------EAVKRGERINI 736
            ...|.:|         :|:|.|:    |:||        |..:.|..:      |.|.|..:...
Human   669 YGTLDSG---------STKEFFR----RSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKG 720

  Fly   737 DWRINLQLIVQRHFEREKECHFALGRESFVDEQIAMIVPAQSAYLHLVNRHIKSMFRMGFIER-- 799
            .:...|:..:..:.|:.|.|.......:...:...:..|..|:....||..:..:...|.:::
Human   721 KFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLK 785

  Fly   800 ---WHQMNLPSAGKCNGKSAQRQVTNHKVNMDDMQGCFLVLLLGFTLALLIVCGEFWYRRFRASR 861
               |:     ..|:|..|.:..:.....:::.::.|.|.:|:.|..||:|:...||.|:. ||..
Human   786 NKWWY-----DKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKS-RAEA 844

  Fly   862 KRRQFT 867
            ||.:.|
Human   845 KRMKLT 850

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.