DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir93a and GRIA3

DIOPT Version :9

Sequence 1:NP_650924.3 Gene:Ir93a / 42471 FlyBaseID:FBgn0259215 Length:868 Species:Drosophila melanogaster
Sequence 2:NP_000819.4 Gene:GRIA3 / 2892 HGNCID:4573 Length:894 Species:Homo sapiens


Alignment Length:955 Identity:166/955 - (17%)
Similarity:322/955 - (33%) Gaps:294/955 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 GGINVKYFSWNAVRLKKDFLAAITVTDCENTWNFYKNTQETSILL------------IAITDSDC 128
            ||:    |..|.|:....|..|:.:      :|..:||.|....|            .::|::.|
Human    37 GGL----FMRNTVQEHSAFRFAVQL------YNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFC 91

  Fly   129 PRL------------------------PLNRALMVPIVENGDEFPQLILDAKVQQIL-------- 161
            .:.                        .|:.:.:.|      .||   .||.||.::        
Human    92 SQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTP------SFP---TDADVQFVIQMRPALKG 147

  Fly   162 ---------NWKTAVVFVDQTILEENALLVKSIVHESITNHITPISLILYEINDSLRGQQKRVAL 217
                     .|:..|...|   .|....::::|:..::.|:        :::.....|..|.|  
Human   148 AILSLLGHYKWEKFVYLYD---TERGFSILQAIMEAAVQNN--------WQVTARSVGNIKDV-- 199

  Fly   218 RQALSQFAPKKHEEMRQQFLV------ISAFHEDIIEIAETLNMFHVGNQWMIFVLDMVARDFDA 276
             |...:...:......:::|:      |:...|.::.:.:....:|.          |:|   :.
Human   200 -QEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHY----------MLA---NL 250

  Fly   277 GTVTINLDE----GANI-AFAL-NETDPNCQ---------------DSLNCTISEISLALVNAIS 320
            |...|.|:.    |||| .|.: |..:|..|               ::.|..:...|....:||.
Human   251 GFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAIL 315

  Fly   321 KITVEEESIYGEISDEEWEAIRFTKQEKQAEILEYMKEFLKTNAKCSSCARWRVETAITWGKSQE 385
            .|.               ||.|:.::::..         :........|.   ...|:.|.:..:
Human   316 VIA---------------EAFRYLRRQRVD---------VSRRGSAGDCL---ANPAVPWSQGID 353

  Fly   386 NRKFRSTPQRDAKNRNFEF----------INI-----------GYWTPVLGFVCQELAFPHIEHH 429
            ..:.....|......|.:|          |::           |||.....||      |..:..
Human   354 IERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFV------PFSDQQ 412

  Fly   430 F-------RNITMDILTVHNPPWQILTKNSNGV--IVEHKGIVMEIVKELSRALNFSYYLH---- 481
            .       .|.|:.:.|:...|:.:..||...:  ...::|..:::..|:::.:...|.|.    
Human   413 ISNDSASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGD 477

  Fly   482 --------EASAWKEEDSLSTSAGGNESDELVGSMTFRIPYRVVEMVQGNQFFIAAVAATVEDPD 538
                    |...|               :.:||           |:|.| :..||....|:....
Human   478 GKYGARDPETKIW---------------NGMVG-----------ELVYG-RADIAVAPLTITLVR 515

  Fly   539 QKPFNYTQPISVQKYSFITRKPDEVS-RIYLFTAPFTVETWFCLMGIILLTAPTLYAINRLAPLK 602
            ::..::::|......|.:.:||.:.. .::.|..|...|.|.|::...:..:..|:.::|.:|.:
Human   516 EEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYE 580

  Fly   603 ---------------------EMRIVGLSTVKSCFWYIFGALLQQGGMYLPTADSGRLVVGFWWI 646
                                 |..|.      :..|:..||.:|||....|.:.|||:|.|.||.
Human   581 WHLEDNNEEPRDPQSPPDPPNEFGIF------NSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWF 639

  Fly   647 VVIVLVTTYCGNLVAFLTFPKFQPGVDYLNQLEDHKDIVQYGLRNGTFFERYVQSTTREDFKHYL 711
            ..::::::|..||.||||..:....::....|....:|....|.:|         :|:|.|:   
Human   640 FTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSG---------STKEFFR--- 692

  Fly   712 ERAKI--------YGSAQEEDI------EAVKRGERINIDWRINLQLIVQRHFEREKECHFALGR 762
             |:||        |..:.|..:      :.|.|..:....:...|:..:..:.|:.|.|......
Human   693 -RSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVG 756

  Fly   763 ESFVDEQIAMIVPAQSAYLHLVNRHIKSMFRMGFIER-----WHQMNLPSAGKCNGKSAQRQVTN 822
            .:...:...:..|..||..:.||..:..:...|.:::     |:     ..|:|.......:...
Human   757 GNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWY-----DKGECGSGGGDSKDKT 816

  Fly   823 HKVNMDDMQGCFLVLLLGFTLALLIVCGEFWYRRFRASRKRRQFT 867
            ..:::.::.|.|.:|:.|..||:::...||.|:. ||..||.:.|
Human   817 SALSLSNVAGVFYILVGGLGLAMMVALIEFCYKS-RAESKRMKLT 860

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir93aNP_650924.3 Periplasmic_Binding_Protein_Type_2 429..>697 CDD:328725 59/310 (19%)
Lig_chan 576..836 CDD:306551 58/299 (19%)
GRIA3NP_000819.4 PBP1_iGluR_AMPA_GluR3 35..409 CDD:380610 70/450 (16%)
PBP2_iGluR_AMPA 422..805 CDD:270433 81/433 (19%)
Glutamate binding. /evidence=ECO:0000250 508..510 0/1 (0%)