Protein Alignment Ir93a and GRIA1

DIOPT Version :9

• Sequence 1: NP_650924.3
• Gene: Ir93a / 42471
• FlyBaseID: FBgn0259215
• Length: 868
• Species: Drosophila melanogaster
• Sequence 2: NP_001244950.1
• Gene: GRIA1 / 2890
• HGNCID: 4571
• Length: 916
• Species: Homo sapiens
• Alignment Length: 882
• Identity: 172/882 - (19%)
• Similarity: 321/882 - (36%)
• Gaps: 224/882 - (25%)

  Fly    82 YFSWNAVRLKKDFLAAITVTDCENTWNFYKNTQETSIL---------LIAITDSDCPRLPLNRAL 137
            ::....|.:...|..|:.|  |..|.:|..:|....:|         ||:|.|    .....:.:
Human    98 FYERRTVNMLTSFCGALHV--CFITPSFPVDTSNQFVLQLRPELQDALISIID----HYKWQKFV 156

  Fly   138 MVPIVENGDEFPQLILDAKVQQILNWKTAVVFVDQTILEENALLVKSIVHESITNHITPISLILY 202
            .:...:.|....|.:||...::  ||:...|.:..|..|...:|.:.:
Human   157 YIYDADRGLSVLQKVLDTAAEK--NWQVTAVNILTTTEEGYRMLFQDL----------------- 202

  Fly   203 EINDSLRGQQKRVALRQALSQFAPKKHEEMRQQFLVISAFHE-------DIIEIAETLNMFHVGN 260
                                       |:.:::.:|:....|       .||::.:....:|
Human   203 ---------------------------EKKKERLVVVDCESERLNAILGQIIKLEKNGIGYH--- 237

  Fly   261 QWMIFVLDMVARDFDAGTVTINL----DEGANI-AFAL-NETDPNCQDSLNCTISEISLALVNAI 319
                ::|      .:.|.:.|:|    :.|||: .|.| |.||         ||.
Human   238 ----YIL------ANLGFMDIDLNKFKESGANVTGFQLVNYTD---------TIP---------- 273

  Fly   320 SKITVE-EESIYGEISDEEWEAIRFTKQEKQAEILEYMKEFLKTNAKC-SSCARWRVE------- 375
            :||..: :.|...:.:..:|      |:.|....|.|  :.:|..|:. .|..|.|::
Human   274 AKIMQQWKNSDARDHTRVDW------KRPKYTSALTY--DGVKVMAEAFQSLRRQRIDISRRGNA 330

  Fly   376 ------TAITWGKS-------------------QENRKFRSTPQRDAKNRNFEFI--------NI 407
                  .|:.||:.                   |.|.|.|.|      |.....|        .|
Human   331 GDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRT------NYTLHVIEMKHDGIRKI 389

  Fly   408 GYWTPVLGFV--CQELAFPHIEHHFRNITMDILTVHNPPWQILTKNSNGV--IVEHKGIVMEIVK 468
            |||.....||  ..:..........:|.|..:.|:...|:.:|.||:|..  ...::|..:|:..
Human   390 GYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAA 454

  Fly   469 ELSRALNFSYYLHEASAWKEEDSLSTSAGGNESDE-----LVGSMTFRIPYRVVEMVQGNQFFIA 528
            |:::.:.:||.|...|..|        .|..:.|.     :||           |:|.| :..:|
Human   455 EIAKHVGYSYRLEIVSDGK--------YGARDPDTKAWNGMVG-----------ELVYG-RADVA 499

  Fly   529 AVAATVEDPDQKPFNYTQPISVQKYSFITRKPDEVS-RIYLFTAPFTVETWFCLMGIILLTAPTL 592
            ....|:....::..::::|......|.:.:||.:.. .::.|..|...|.|.|::...:..:..|
Human   500 VAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVL 564

  Fly   593 YAINRLAP-------LKEMRIVGLSTVKSCF------WYIFGALLQQGGMYLPTADSGRLVVGFW 644
            :.::|.:|       .:|.|....|...:.|      |:..||.:|||....|.:.|||:|.|.|
Human   565 FLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVW 629

  Fly   645 WIVVIVLVTTYCGNLVAFLTFPKFQPGVDYLNQLEDHKDIVQYGLRNGT---FFERYVQSTTRED 706
            |...::::::|..||.||||..:....::....|....:|....|..|:   ||.| .:....|.
Human   630 WFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRR-SKIAVFEK 693

  Fly   707 FKHYLERAK--IYGSAQEEDIEAVKRGERINIDWRINLQLIVQRHFEREKECHFALGRESFVDEQ 769
            ...|::.|:  ::....||.:..|::.:.   .:...|:..:..:.|:.|.|.......:...:.
Human   694 MWTYMKSAEPSVFVRTTEEGMIRVRKSKG---KYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKG 755

  Fly   770 IAMIVPAQSAYLHLVNRHIKSMFRMGFIER-----WHQMNLPSAGKCNGKSAQRQVTNHKVNMDD 829
            ..:..|..||..:.||..:..:...|.:::     |:     ..|:|.......:.....:::.:
Human   756 YGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWY-----DKGECGSGGGDSKDKTSALSLSN 815

  Fly   830 MQGCFLVLLLGFTLALLIVCGEFWYRRFRASRKRRQF 866
            :.|.|.:|:.|..||:|:...||.|:....|::.:.|
Human   816 VAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMKGF 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	68/291 (23%)
		Lig_chan	576..836	CDD:306551	59/282 (21%)
GRIA1	NP_001244950.1	PBP1_iGluR_AMPA_GluR1	36..399	CDD:107385	70/398 (18%)
		ANF_receptor	47..382	CDD:279440	66/381 (17%)
		PBP2_iGluR_AMPA_GluR1	416..797	CDD:270447	87/409 (21%)
		Lig_chan	548..827	CDD:278489	60/287 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155988
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940