DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and Grin2c

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_036707.3	Gene:	Grin2c / 24411	RGDID:	2739	Length:	1250	Species:	Rattus norvegicus

Alignment Length:	821	Identity:	162/821 - (19%)
Similarity:	299/821 - (36%)	Gaps:	200/821 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 VVFVDQTILEENALL---VKSIVHESITNHITPISLILYEINDSLRGQQKRVALRQALSQFAPKK 228
            :||.|....|..|.|   |.|..|..|.:.....:::|..........|..|:|.|.|.......
  Rat   106 IVFEDNVDTEAVAQLLDFVSSQTHVPILSISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVL 170

  Fly   229 HEEMRQQFLVISAFH-------EDIIEIAETLNMFHVGNQWMIFVLDMVARDFDAG-------TV 279
            .|.....|.||::.|       |.:..:|:...:     .|.:  ||::..:...|       .:
  Rat   171 EEYDWSAFAVITSLHPGHALFLEGVRAVADASYL-----SWRL--LDVLTLELGPGGPRARTQRL 228

  Fly   280 TINLDEGANIAFALNETD---------------------PNCQDSLNCTISEISLALVNAISKIT 323
            ...:|....:|:...|..                     ||.  :|..|.:..:...|..||.:|
  Rat   229 LRQVDAPVLVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNL--ALGSTDAPPAAFPVGLISVVT 291

  Fly   324 VEEESIYGEISDEEWEAIRFTKQEKQAEIL-----EYMKEFLKTNAKCSSC------------AR 371
                        |.|......|......||     .|.:::....|....|            |.
  Rat   292 ------------ESWRLSLRQKVRDGVAILALGAHSYRRQYGTLPAPAGDCRSHPGPVSPAREAF 344

  Fly   372 WRVETAITWGKSQENRKF---------RSTPQRDAKNRNFEFINIGYWT--------PVLGFVCQ 419
            :|....:||    |.|.|         |.|....|.||:..:..:|.|.        ||......
  Rat   345 YRHLLNVTW----EGRDFSFSPGGYLVRPTMVVIALNRHRLWEMVGRWDHGVLYMKYPVWPRYST 405

  Fly   420 ELAFPHIEHHFRNITMDILTVHNPPWQILTKN----------------------SNGVIVEH--- 459
            .|. |.::.  |::|  :.|:...|:.|:...                      |:|.:..:
  Rat   406 SLQ-PVVDS--RHLT--VATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDLTPYTKL 465

  Fly   460 --KGIVMEIVKELSRALNFSYYLHEASAWKEEDSLSTSAGGNESDELVGSMTFRIPYRVVEMVQG 522
              ||..::|:|:|::.:.|||.|:..:..|.         |.....:...|...:.|:..:|..|
  Rat   466 CCKGFCIDILKKLAKVVKFSYDLYLVTNGKH---------GKRVRGVWNGMIGEVYYKRADMAIG 521

  Fly   523 NQFFIAAVAATVEDPDQKPFNYTQP-----ISVQKYSFITRKPDEVSRIYLFTAPFTVETWFCLM 582
                    :.|:.:...:..:::.|     |||    .::|....||. ..|..|::...| .:|
  Rat   522 --------SLTINEERSEIIDFSVPFVETGISV----MVSRSNGTVSP-SAFLEPYSPAVW-VMM 572

  Fly   583 GIILLT--APTLYAINRLAPL-------KEMRIVGLS-TVKSCFWYIFGALLQQGGMYL--PTAD 635
            .::.||  |.|::.....:|:       |..:..|.| |:....|.:: ||:....:.:  |...
  Rat   573 FVMCLTVVAITVFMFEYFSPVSYNQNLTKGKKPGGPSFTIGKSVWLLW-ALVFNNSVPIENPRGT 636

  Fly   636 SGRLVVGFWWIVVIVLVTTYCGNLVAFLTFPKFQPGVDYLNQLEDHK-----DIVQY-GLRNGTF 694
            :.:::|..|....::.:.:|..||.||:...::   :|.::.|.|.|     |  || ..|.||.
  Rat   637 TSKIMVLVWAFFAVIFLASYTANLAAFMIQEQY---IDTVSGLSDKKFQRPQD--QYPPFRFGTV 696

  Fly   695 ----FERYVQSTTREDFKHYLERAKIYGSAQEEDIEAVKRGERINIDWRINLQLIVQRHFEREKE 755
                .||.::|..|:...|.:   |....:.|:.:.::|.|:   :|..|....::.....:::.
  Rat   697 PNGSTERNIRSNYRDMHTHMV---KFNQRSVEDALTSLKMGK---LDAFIYDAAVLNYMAGKDEG 755

  Fly   756 CHF-ALGR-ESFVDEQIAMIVPAQSAYLHLVNRHIKSMFRMGFIERWHQMNLPSAGKCNGKSAQR 818
            |.. .:|. :.|......:.:...|.:...::..:..:...|..::...:.|  :|.|  ::.:.
  Rat   756 CKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQLLGDGETQKLETVWL--SGIC--QNEKN 816

  Fly   819 QVTNHKVNMDDMQGCFLVLLLGFTLALLIVCGE---FWYRR 856
            :|.:.|:::|:|.|.|.:||:...||||:...|   :|..|
  Rat   817 EVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLR 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	64/321 (20%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	57/283 (20%)
Grin2c	NP_036707.3	PBP1_iGluR_NMDA_NR2	41..397	CDD:380601	60/315 (19%)
		PBP2_iGluR_NMDA_Nr2	413..813	CDD:270436	83/442 (19%)
		NMDAR2_C	850..>925	CDD:402274	2/8 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349923
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930