DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir93a and Grin2a

DIOPT Version :9

Sequence 1:NP_650924.3 Gene:Ir93a / 42471 FlyBaseID:FBgn0259215 Length:868 Species:Drosophila melanogaster
Sequence 2:NP_036705.3 Gene:Grin2a / 24409 RGDID:2737 Length:1464 Species:Rattus norvegicus


Alignment Length:819 Identity:155/819 - (18%)
Similarity:313/819 - (38%) Gaps:178/819 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   136 ALMVPIVENGDEFPQLILDAKVQQILNWK--TAVVFVDQTILEENALLVKSIVHE------SITN 192
            |.|:..:.:....|.|.:......|:..|  |:..|.....:::.|.::..|:.:      |:..
  Rat   110 AQMLDFISSQTFIPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVT 174

  Fly   193 HITP-----ISLILYEINDSLRG--QQKRVAL----RQALSQFAPKK-HEEMRQQFLVISAFHED 245
            .|.|     ||.|...:::|..|  .|..:.|    ..|.:|...|| |..:   .|:..:..|.
  Rat   175 TIFPGYRDFISFIKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSV---ILLYCSKDEA 236

  Fly   246 IIEIAETLNMFHVGNQ--WMIFVL-----DMVARDFDAGTVTINLDEGANIAFALNETDPNCQDS 303
            ::.::|..::...|..  |::..|     :::.::|.:|.::::.|:.   .::|   :...:|.
  Rat   237 VLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDW---DYSL---EARVRDG 295

  Fly   304 LNCTISEISLALVNAISKITVEEESIYGEISDEEWEAIRFTKQEKQAEILEYMKEFLKTNAKCSS 368
            |....:..| :::...|.|...:.|.||:             .||....|..:.:|:        
  Rat   296 LGILTTAAS-SMLEKFSYIPEAKASCYGQ-------------AEKPETPLHTLHQFM-------- 338

  Fly   369 CARWRVETAITW-GK----SQENRKFRSTPQRDAKNRNFEFINIGYWTPVLGFVCQELAFPHI-- 426
                   ..:|| ||    ::|..:..........|::.|:..:|.|..      |.|:..|.  
  Rat   339 -------VNVTWDGKDLSFTEEGYQVHPRLVVIVLNKDREWEKVGKWEN------QTLSLRHAVW 390

  Fly   427 ------------EHHFRNITM-----------DILT---VHNP-PWQILTKNSN----GVIVEH- 459
                        ::|...:|:           |.||   |.|. |.:...|.:|    |:.|:. 
  Rat   391 PRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKC 455

  Fly   460 -KGIVMEIVKELSRALNFSYYLHEASAWKEEDSLSTSAGGNESDELVGSMTFRIPYRVVEMVQGN 523
             ||..::|:|:|||.:.|:|.|:..:..|.         |.:.:.:...|...:.|:...|..| 
  Rat   456 CKGFCIDILKKLSRTVKFTYDLYLVTNGKH---------GKKVNNVWNGMIGEVVYQRAVMAVG- 510

  Fly   524 QFFIAAVAATVEDPDQKPFNYTQP-----ISVQKYSFITRKPDEVSRIYLFTAPFTVETWFCLMG 583
                   :.|:.:...:..:::.|     |||    .::|....||. ..|..||:...|..:..
  Rat   511 -------SLTINEERSEVVDFSVPFVETGISV----MVSRSNGTVSP-SAFLEPFSASVWVMMFV 563

  Fly   584 IILL-TAPTLYAINRLAPLKEMRIVGLS--------TVKSCFWYIFGALLQQG-GMYLPTADSGR 638
            ::|: :|..::.....:|:...|.:...        |:....|.::|.:.... .:..|...:.:
  Rat   564 MLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSK 628

  Fly   639 LVVGFWWIVVIVLVTTYCGNLVAFLTFPKFQPGVDYLNQLEDHK-----DIVQYG--LRNGTFFE 696
            ::|..|....::.:.:|..||.||:...:|   ||.:..|.|.|     |   |.  .|.||...
  Rat   629 IMVSVWAFFAVIFLASYTANLAAFMIQEEF---VDQVTGLSDKKFQRPHD---YSPPFRFGTVPN 687

  Fly   697 RYVQSTTREDFKH---YLERAKIYGSAQEEDIEAVKRGERINIDWRINLQLIVQRHFEREKECHF 758
            ...:...|.::.:   |:.|....|  .|:.:.::|.|:   :|..|....::.....|::.|..
  Rat   688 GSTERNIRNNYPYMHQYMTRFNQRG--VEDALVSLKTGK---LDAFIYDAAVLNYKAGRDEGCKL 747

  Fly   759 ALGRESFVDEQIAMIVPAQ--SAYLHLVNRHIKSMFRMGFIERWHQMNLPSAGKCNGKSAQRQVT 821
            ......::.......:..|  |.:...::..:......|.:|....:.|  .|.|:.:  :.:|.
  Rat   748 VTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWL--TGICHNE--KNEVM 808

  Fly   822 NHKVNMDDMQGCFLVLLLGFTLALLIVCGE---FWYRRF 857
            :.::::|:|.|.|.:|.....|:|:....|   :|..||
  Rat   809 SSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRF 847

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir93aNP_650924.3 Periplasmic_Binding_Protein_Type_2 429..>697 CDD:328725 66/310 (21%)
Lig_chan 576..836 CDD:306551 50/281 (18%)
Grin2aNP_036705.3 PBP1_iGluR_NMDA_NR2 32..392 CDD:107373 59/325 (18%)
PBP2_iGluR_NMDA_Nr2 403..802 CDD:270436 84/433 (19%)
HisJ <458..>541 CDD:223904 21/103 (20%)
Glutamate binding. /evidence=ECO:0000269|PubMed:16281028, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8, ECO:0007744|PDB:5I56, ECO:0007744|PDB:5I57, ECO:0007744|PDB:5I58, ECO:0007744|PDB:5I59, ECO:0007744|PDB:5JTY 511..513 0/1 (0%)
Lig_chan 556..828 CDD:278489 51/286 (18%)
Pore-forming. /evidence=ECO:0000250|UniProtKB:B7ZSK1 599..620 3/20 (15%)