DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and Grin3a

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_001263284.1	Gene:	Grin3a / 242443	MGIID:	1933206	Length:	1135	Species:	Mus musculus

Alignment Length:	969	Identity:	172/969 - (17%)
Similarity:	330/969 - (34%)	Gaps:	287/969 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLLAGLQLSILVPTEAN-------DFSS----FLSANASLAVVVDHEYMTVHGENILAHFEKILS 66
            ||...|.|.:::..||.       .|||    :.|...|....|.|. :.|.|.:.|..|.:...
Mouse   141 LLPYNLSLEVVMAIEAGLGDLPLMPFSSPSSPWSSDPFSFLQSVCHT-VVVQGVSALLAFPQSQG 204

  Fly    67 DVIRENLRNGGINVKYFSWNAVR--------------------LKKDFLAAITVTDCENTWNFYK 111
            :::..:|.:..:::...|  .||                    |..|....:::....|.:||
Mouse   205 EMMELDLVSSVLHIPVLS--IVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNF-- 265

  Fly   112 NTQETSILLIA----ITDSDCPRLPLNRALMVPIVENGDEFPQLILDAKVQQILNWKTAVVFVDQ 172
                 |:||..    |||            .:.:.||..:|       .::.|:|
Mouse   266 -----SLLLCQEDWNITD------------FLLLTENNSKF-------HLESIIN---------- 296

  Fly   173 TILEENALLVKSIVH------ESITNHITPISLILYEIN-DSLRGQQKRVALRQALSQFA---PK 227
              :..|....|.::.      |:|.|. || :::::..: .|:|      .:.:..:||.   |.
Mouse   297 --ITANLSSTKDLLSFLQVQLENIRNS-TP-TMVMFGCDMGSIR------QIFEMSTQFGLSPPD 351

  Fly   228 KH---------EEMRQQFLVISAFHEDIIEIAETLNMFHVGNQWMIFVLDMVARDFDAGTVTINL 283
            .|         ||:|.:.|.:..       ||.......|...::...:::|||  ...|.|:..
Mouse   352 LHWVLGDSQNVEELRTEGLPLGL-------IAHGKTTQSVFEYYVQDAMELVAR--AVATATMIQ 407

  Fly   284 DEGANIAFALNETDPNCQD--SLNCTISEISLALVNAISKITVEEESIYGEISDEEWEAIRFTKQ 346
            .|     .||..:..||.|  :.|.|..
Mouse   408 PE-----LALLPSTMNCMDVKTTNLTSG------------------------------------- 430

  Fly   347 EKQAEILEYMKEFL--KTNAKCSSCARWRVETAITWGKSQENRKFRSTPQRDAKNRNFEFINIGY 409
                   :|:..||  .|....|...:.:..|.:    |.||..|....|.|...:.. :..:|.
Mouse   431 -------QYLSRFLANTTFRGLSGSIKVKGSTIV----SSENNFFIWNLQYDPMGKPM-WTRLGS 483

  Fly   410 WTPVLGFVCQELAF---------PHIEH----HFRNIT------------------------MDI 437
            |..  |.:..:...         .|..|    |.|.:|                        :|.
Mouse   484 WQG--GRIVMDSGIWPEQAQRHKTHFHHPNKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDP 546

  Fly   438 LT----VHNPPWQILTKNSNGVIVEHK----GIVMEIVKELSRALNFSYYLH-----EASAWKEE 489
            :|    :.:..:..|..:::.|.::.|    |..::::::|:..:||.:.|:     :..|||
Mouse   547 MTNDSSILDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAWK-- 609

  Fly   490 DSLSTSAGGNESDELVGSMTFRIPYRVVEMVQGNQFFIAAVAATVEDPDQKPFNYTQPISVQKYS 554
                   .|:.:. |||           :::.|.. .:|..:.::.....:..::|.|.......
Mouse   610 -------NGHWTG-LVG-----------DLLSGTA-NMAVTSFSINTARSQVIDFTSPFFSTSLG 654

  Fly   555 FITRKPDEVSRIYLFTAPFTVETWFCLMGIILLTAPTLYAINRLAPL-------KEMRIVGLST- 611
            .:.|..|..:.|..|..|.....|..:...:.:||..|......:|.       ...::...|:
Mouse   655 ILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAIFLTLYEWKSPFGMTPKGRNRNKVFSFSSA 719

  Fly   612 VKSCFWYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIVLVTTYCGNLVAFLTFPKFQPGVDYLN 676
            :..|:..:||   :...:..|...:||.::..|.|..:..::||..||.|.:...|....:..::
Mouse   720 LNVCYALLFG---RTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIH 781

  Fly   677 QLEDHKDIVQYGLRNGTFFERYVQSTTREDFKHYLERAKIYG-SAQEEDIEAVKRG-ERIN---- 735
            ..:.|..  ..|.|.||..|...:...|:.|....|..:.|. .|..:.::.:|.. |:::
Mouse   782 DPKLHHP--SQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVQYLKNDPEKLDAFIM 844

  Fly   736 ----IDWRINLQLIVQRHFEREKECHFALGRESFVDEQIAMIVPAQSAYLHLVNRHIKSMFRMGF 796
                :|:.:::          :.:|......:.|..|...:.:|..|.....::..|......||
Mouse   845 DKALLDYEVSI----------DADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGF 899

  Fly   797 I----ERWHQMNLPSAGKCNGKSAQRQVTNHKVNMDDMQGCFLVLLLGFTLALLIVCGE 851
            :    ::|::: :|    | ||.:.......::.:....|.|::|.:||.|::|...||
Mouse   900 MDVLHDKWYKV-VP----C-GKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGE 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	54/312 (17%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	49/281 (17%)
Grin3a	NP_001263284.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	85/469 (18%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	71/432 (16%)
		Lig_chan	676..942	CDD:278489	50/286 (17%)
		PPP2CB binding site. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	951..987		2/2 (100%)
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1082..1115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846422
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930