DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and Grin3a

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_612555.1	Gene:	Grin3a / 191573	RGDID:	621704	Length:	1135	Species:	Rattus norvegicus

Alignment Length:	983	Identity:	174/983 - (17%)
Similarity:	334/983 - (33%)	Gaps:	295/983 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLLAGLQLSILVPTEAN-------DFSS----FLSANASLAVVVDHEYMTVHGENILAHFEKILS 66
            ||...|.|.:::..||.       .|||    :.|...|....|.|. :.|.|.:.|..|.:...
  Rat   141 LLPYNLSLEVVMAIEAGLGDLPLMPFSSPSSPWSSDPFSFLQSVCHT-VVVQGVSALLAFPQSQG 204

  Fly    67 DVIRENLRNGGINVKYFSWNAVR--------------------LKKDFLAAITVTDCENTWNFYK 111
            :::..:|.:..:::...|  .||                    |..|....:::....|.:||
  Rat   205 EMMELDLVSSVLHIPVLS--IVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNF-- 265

  Fly   112 NTQETSILLIA----ITDSDCPRLPLNRALMVPIVENGDEFPQLILDAKVQQILNWKTAVVFVDQ 172
                 |:||..    |||            .:.:.||..:|       .::.::|
  Rat   266 -----SLLLCQEDWNITD------------FLLLTENNSKF-------HLESVIN---------- 296

  Fly   173 TILEENALLVKSIVH------ESITNHITPISLILYEIN-DSLRGQQKRVALRQALSQFA---PK 227
              :..|....|.::.      ::|.|. || :::::..: ||:|      .:.:..:||.   |:
  Rat   297 --ITANLSSTKDLLSFLQVQMDNIRNS-TP-TMVMFGCDMDSIR------QIFEMSTQFGLSPPE 351

  Fly   228 KH---------EEMRQQFLVISAFHEDIIEIAETLNMFHVGNQWMIFVLDMVARDFDAGTVTINL 283
            .|         ||:|.:.|.:..       ||.......|...::...:::|||  ...|.|:..
  Rat   352 LHWVLGDSQNVEELRTEGLPLGL-------IAHGKTTQSVFEYYVQDAMELVAR--AVATATMIQ 407

  Fly   284 DEGANIAFALNETDPNCQD--SLNCTISEISLALVNAISKITVEEESIYGEISDEEWEAIRFTKQ 346
            .|     .||..:..||.|  :.|.|..
  Rat   408 PE-----LALLPSTMNCMDVKTTNLTSG------------------------------------- 430

  Fly   347 EKQAEILEYMKEFL--KTNAKCSSCARWRVETAITWGKSQENRKFRSTPQRDAKNRNFEFINIGY 409
                   :|:..||  .|....|...:.:..|.|    |.||..|....|.|...:.. :..:|.
  Rat   431 -------QYLSRFLANTTFRGLSGSIKVKGSTII----SSENNFFIWNLQHDPMGKPM-WTRLGS 483

  Fly   410 WTPVLGFVCQELAF---------PHIEH----HFRNITMDILTVHNP------------------ 443
            |..  |.:..:...         .|.:|    |.|.:|:    :.:|
  Rat   484 WQG--GRIVMDSGIWPEQAQRHKTHFQHPNKLHLRVVTL----IEHPFVFTREVDDEGLCPAGQL 542

  Fly   444 ---P-----------WQILTKNSNGVIVEHK----GIVMEIVKELSRALNFSYYLH-----EASA 485
               |           :..|..:::.|.::.|    |..::::::|:..:||.:.|:     :..|
  Rat   543 CLDPMTNDSSMLDRLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGA 607

  Fly   486 WKEEDSLSTSAGGNESDELVGSMTFRIPYRVVEMVQGNQFFIAAVAATVEDPDQKPFNYTQPISV 550
            ||         .|:.:. |||           :::.|.. .:|..:.::.....:..::|.|...
  Rat   608 WK---------NGHWTG-LVG-----------DLLSGTA-NMAVTSFSINTARSQVIDFTSPFFS 650

  Fly   551 QKYSFITRKPDEVSRIYLFTAPFTVETWFCLMGIILLTAPTLYAINRLAPL-------KEMRIVG 608
            .....:.|..|..:.|..|..|.....|..:...:.:||..|......:|.       ...::..
  Rat   651 TSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAIFLTLYEWKSPFGMTPKGRNRNKVFS 715

  Fly   609 LST-VKSCFWYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIVLVTTYCGNLVAFLTFPKFQPGV 672
            .|: :..|:..:||   :...:..|...:||.::..|.|..:..::||..||.|.:...|....:
  Rat   716 FSSALNVCYALLFG---RTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEEL 777

  Fly   673 DYLNQLEDHKDIVQYGLRNGTFFERYVQSTTREDFKHYLERAKIYG-SAQEEDIEAVKRG-ERIN 735
            ..::..:.|..  ..|.|.||..|...:...|:.|....|..:.|. .|..:.::.:|.. |:::
  Rat   778 SGIHDPKLHHP--SQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVQYLKNDPEKLD 840

  Fly   736 --------IDWRINLQLIVQRHFEREKECHFALGRESFVDEQIAMIVPAQSAYLHLVNRHIKSMF 792
                    :|:.:::          :.:|......:.|..|...:.:|..|.....::..|....
  Rat   841 AFIMDKALLDYEVSI----------DADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYK 895

  Fly   793 RMGFI----ERWHQMNLPSAGKCNGKSAQRQVTNHKVNMDDMQGCFLVLLLGFTLALLIVCGEFW 853
            ..||:    ::|::: :|    | ||.:.......::.:....|.|::|.:||.|::|...||..
  Rat   896 SHGFMDVLHDKWYKV-VP----C-GKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHI 954

  Fly   854 YRRFRASR 861
            ..|....|
  Rat   955 VHRLLLPR 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	54/316 (17%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	49/281 (17%)
Grin3a	NP_612555.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	85/469 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..117
		ANF_receptor	127..469	CDD:279440	80/438 (18%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	71/436 (16%)
		Lig_chan	676..942	CDD:278489	50/286 (17%)
		PPP2CB binding site	951..987		4/12 (33%)
		GIT1-binding. /evidence=ECO:0000269\|PubMed:24297929	1082..1115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349910
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930