DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and glr-6

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_741822.2	Gene:	glr-6 / 180955	WormBaseID:	WBGene00001617	Length:	844	Species:	Caenorhabditis elegans

Alignment Length:	826	Identity:	160/826 - (19%)
Similarity:	307/826 - (37%)	Gaps:	193/826 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 LDAKVQQILNWKTAVVF--VDQ---TILEENALLVKSIVHESITNHITPISLILYEINDSLRGQQ 212
            |:.|:..:.|.:.:|:.  ||:   :|:||....:..:.   |..:.||             |.|
Worm    73 LNTKICDLANSEVSVIIGVVDRESGSIIEEQCAELNILF---IHYYWTP-------------GYQ 121

  Fly   213 KRVALRQALSQFAPKKHEEMRQQ---------FLVISAFHEDIIEIAETLNMFHVGNQWMIFVLD 268
            |:  .:.:|:.:...::.::.::         |:.|.:.::...::.|||:.           |:
Worm   122 KK--QQTSLNLYPSMEYSQLMERLINLWRWDNFVYIYSNYDAPKQLIETLSR-----------LE 173

  Fly   269 MVARDFDAGTVTINLDEGANIAFALNET-DPN-CQDSLNCTISEIS----LALVNAISKITVEEE 327
            .......|.|:.   |.....|.||.:| |.| |....|..:.|:|    |...:|..|:
Worm   174 KSPALLRAHTLD---DSMMATALALRDTCDRNRCWPKKNRVLIELSPNETLTFFDASLKL----- 230

  Fly   328 SIYGEISDEEWEAI-----------RFTKQEKQAEILEYMKEFLKTN--------------AKCS 367
               |.||...|..|           ::|....:..:|...||....|              ||..
Worm   231 ---GMISVHNWFLITALDDLNDHLSQYTHNGMRVSLLTVSKEKWNQNDLAIKLPDMYQEYLAKIP 292

  Fly   368 SCARWRVE------------------TAITWGKSQENRKFR------------------STPQRD 396
            |..|...:                  ..|:.|.::..:||:                  ::.:.|
Worm   293 SNPRTPFKDFAFIFDSILLACQAGDRRIISCGDNEAVKKFKLPIVKPFKGLTGKISFNGTSDRSD 357

  Fly   397 AKNRNFEF------INIGYW------TPVLGFVCQELAFPHIEHHFRNI----TMDILTVHNPPW 445
            ::...:|.      ::.|.|      :..|..:.:.:...| ||:..::    |:.:.::|..|:
Worm   358 SELHIWEMGITGAGLHTGIWKSTWEGSKELTMLAKNIPGTH-EHYQASVRESRTLKVTSIHEKPY 421

  Fly   446 QILTKNSNGVIVEHKGIVMEIVKELSRALNFSYYLHEASAWKEEDSLSTSAGGNESDELVGSMTF 510
            .|.....:|.| :|:|..::::.:|:..|:|:|.|   ...|:........|.:|.|.::|
Worm   422 VIEKIMPDGRI-KHEGFCVDLLDKLAEMLHFNYTL---KIVKDNKYGERKNGTDEWDGMIG---- 478

  Fly   511 RIPYRVVEMVQGNQFFIAAVAATVEDPDQKPFNYTQPISVQKYSFITRKPDEVSRIYL--FTAPF 573
                   |:::|:. .:|....||.....:..::|.|......|.:.|:|:..|...|  |..|.
Worm   479 -------EILRGDA-DMAVAPITVTATRLEVIDFTDPFLQLGISMLMRQPNPKSSSSLTRFLWPL 535

  Fly   574 TVETWFCLMGIILLTAPTLYAINRLAPLKEMRIVGLST----VKSCFWYIFGALLQQGGMYLPTA 634
            :...|.......::||..:.....|:| ||      ||    :::..||:...||:.|..|...|
Worm   536 SASVWTFSAIATVITALLVTVAAVLSP-KE------STAEFKIQNSVWYLVCILLRAGSGYNCQA 593

  Fly   635 DSGRLVVGFWWIVVIVLVTTYCGNLVAFLTFP-KFQPGVDYLNQLEDHKDIVQYGLRN--GTFFE 696
            .:.||:...||...:||:..|..|..|.||.. |..|    .|..|:..:..:|...:  |....
Worm   594 GATRLISAVWWSFTLVLIAQYTANFAALLTVDRKSMP----FNSFEELGNQTEYNFGSILGGSTM 654

  Fly   697 RYVQSTTREDFKHYLERAK-----IYGSAQEEDIEAVKRGERINIDWRINLQLIVQRHFEREKEC 756
            ::.:.:..|.|:...||.:     .:.....|.:..|...:.:.:.....|...|.::....:..
Worm   655 QFFKYSRIETFRRLWERMQSAEPSAFVGTNHEGVNRVLNEKYVFLMESATLDYQVTQNCNLTRVG 719

  Fly   757 HFALGRESFVDEQIAMIVPAQSAYLHLVNRHIKSMFRMGFI----ERWHQMNLPSAGKCNGKSAQ 817
            :..||...:     ::.:|..|.:...:.|.|..:...|.|    ..|.:   .|..:|  :|::
Worm   720 NVVLGSNGY-----SIALPKGSKWREKLTRQILDLNEKGIILMLKNNWWK---KSQQEC--QSSE 774

  Fly   818 RQVTNHKVNMDDMQGCFLVLLLGFTLALLIVCGEFWYRRFRASRKR 863
            .:.....:..:::.|.||:|.||..:.:|....|..:..|....||
Worm   775 PEDLQTALGAENVYGLFLLLALGSGIGVLCAVLEHTHFIFFEKNKR 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	65/280 (23%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	55/275 (20%)
glr-6	NP_741822.2	PBP1_iGluR_non_NMDA-like	21..394	CDD:380591	61/360 (17%)
glr-6	NP_741822.2	PBP2_iGluR_Kainate	409..764	CDD:270432	82/386 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010