DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and Grin3b

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_579842.2	Gene:	Grin3b / 170796	RGDID:	621705	Length:	1002	Species:	Rattus norvegicus

Alignment Length:	949	Identity:	167/949 - (17%)
Similarity:	273/949 - (28%)	Gaps:	342/949 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 LIAITDSDCPRLPLN-----------------------RALMVPIVENGDEFPQLILDAKVQQIL 161
            ::|...:..||||.|                       :.|..|.|.....||:...:.::.|.|
  Rat    55 VLAALATPAPRLPHNLSLELVAVASPTRDPASLARGLCQVLAPPGVVASIAFPEARPELRLLQFL 119

  Fly   162 NWKTAVVFVD--------------------------QTILEENALLVKSIVHESI---------- 190
            ...|....|.                          :|||:....||::...|.|
  Rat   120 AAATETPVVSVLRREVRTALGAPTPFHLQLDWASPLETILDVLVSLVRAHAWEDIALVLCRVRDP 184

  Fly   191 -------TNHITPISLILYEI------NDSLR----------GQQKRVALRQALSQFAPKKHEEM 232
                   |||.:.....:.::      |||||          |....|.....|.....:.||
  Rat   185 GSLVTLWTNHASQAPKFVLDLSRLDSRNDSLRAGLALLGALEGGGTPVPAAVLLGCSTARAHE-- 247

  Fly   233 RQQFLVISAFHEDIIEIAETLNMFHVGNQWMIFVLDMVARDFDAGT-------VTINLDEGANIA 290
                         ::|.|..      |.||::            ||       .|..|..|   .
  Rat   248 -------------VLEAAPP------GPQWLL------------GTPLPAEALPTTGLPPG---V 278

  Fly   291 FALNETDPNCQDSLNCTISEISLALVNAISKITVEEESIYGEISDEEWEAIRFTKQEKQAEILEY 355
            .||.||:   |.||...:.::...:..|:|.:.:    ::.|
  Rat   279 LALGETE---QHSLEAVVHDMVELVAQALSSMAL----VHPE----------------------- 313

  Fly   356 MKEFLKTNAKCSSCARWRVETAITWGKSQENRKFRSTPQRDAKNRNFEFINIGYWTPVLGFVCQE 420
             :..|.....|....        |.|.....|    |..|...|.:|:......|......|
  Rat   314 -RALLPAVVNCDDLK--------TGGSEATGR----TLARFLGNTSFQGRTGAVWVTGSSQV--- 362

  Fly   421 LAFPHIEHHFR--NITMDILTVHNPPWQILTKNSNG----------------------------V 455
                |:..||:  ::..|.|..  |.|..:....:|                            .
  Rat   363 ----HVSRHFKVWSLRRDPLGA--PAWATVGSWQDGQLDFQPGAAALRVPSPSGTQARPKLRVVT 421

  Fly   456 IVEHK---------------------------------------------------GIVMEIVKE 469
            :|||.                                                   |..:::::.
  Rat   422 LVEHPFVFTRESDEDGQCPAGQLCLDPGTNDSARLDALFAALVNGSVPRTLRRCCYGYCIDLLER 486

  Fly   470 LSRALNFSYYLHEASAWKE---EDSLSTSAGGNESDELVGSMTFRIPYRVVEMVQGNQFFIAAVA 531
            |:..|.|.:.|:.....|.   .|...|...|   |.|.|.....:          ..|.|.:..
  Rat   487 LAEDLAFDFELYIVGDGKYGALRDGRWTGLVG---DLLAGRAHMAV----------TSFSINSAR 538

  Fly   532 ATVEDPDQKPFNYTQPISVQKYSFITRKPDEVSRIYLFTAPFTVETWFCLMGIILLTA--PTLYA 594
            :.|.|       :|.|........:.|..|..|.|..|..|.....|..:...:.|||  .|||.
  Rat   539 SQVVD-------FTSPFFSTSLGIMVRTRDTASPIGAFMWPLHWSMWVGVFAALHLTALFLTLYE 596

  Fly   595 INR---LAPLKEMRIVGL-----STVKSCFWYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIVL 651
            ...   |.|....|  |.     |.:..|:..:||..:..   ..|...:||.::..|.|..:::
  Rat   597 WRSPYGLTPRGRNR--GTVFSYSSALNLCYAILFGRTVSS---KTPKCPTGRFLMNLWAIFCLLV 656

  Fly   652 VTTYCGNLVAFLTFPKFQPGVDYLNQLEDHK-DIVQYGLRNGTFFERYVQSTTREDFKHYLERAK 715
            :::|..||.|.:...|   ..:.|:.:.|.| .....|.|.||.:|...::..:..|      .:
  Rat   657 LSSYTANLAAVMVGDK---TFEELSGIHDPKLHHPSQGFRFGTVWESSAEAYIKASF------PE 712

  Fly   716 IYGSAQEEDIEAVKRG--------ERIN--------IDWRINLQLIVQRHFEREKECHFALGRES 764
            ::...:.........|        .::|        :|:.:::          :.:|......:.
  Rat   713 MHAHMRRHSAPTTPHGVAMLTSDPPKLNAFIMDKSLLDYEVSI----------DADCKLLTVGKP 767

  Fly   765 FVDEQIAMIVPAQSAYLHLVNRHIKSMFRMGFI----ERWHQMNLPSAGKCNGKSAQRQVTNHKV 825
            |..|...:.:|..|.....::..|......|||    ::|::| :|    | ||.........::
  Rat   768 FAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKM-VP----C-GKRVFAVTETLQM 826

  Fly   826 NMDDMQGCFLVLLLGFTLALLIVCGEFWYRRFRASRKRR 864
            .:....|.|::|.||...|||...||..:.|....|.||
  Rat   827 GVYHFSGLFVLLCLGLGSALLTSLGEHVFYRLVLPRIRR 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	66/362 (18%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	54/290 (19%)
Grin3b	NP_579842.2	PBP1_iGluR_NMDA_NR3	21..405	CDD:107372	74/437 (17%)
		PBP2_iGluR_NMDA_Nr3	414..808	CDD:270438	73/437 (17%)
		Lig_chan	576..842	CDD:278489	56/295 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	882..910
		Involved in the trafficking and surface expression of NMDARs. /evidence=ECO:0000250	951..984
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349921
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930