DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir93a and gria3a

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	XP_005165152.1	Gene:	gria3a / 170452	ZFINID:	ZDB-GENE-020125-5	Length:	903	Species:	Danio rerio

Alignment Length:	843	Identity:	150/843 - (17%)
Similarity:	281/843 - (33%)	Gaps:	254/843 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 PQLILDAKVQQIL-----------------NWKTAVVFVD--------QTILEENALLVKSIVHE 188
            |....|..||.:|                 .|:..|...|        |.|:|...:....:...
Zfish   120 PSFPTDTDVQFVLQMRPSLRGALLSLLAHYKWEKFVYLYDTDRGFSILQAIMESAVMNNWQVTAR 184

  Fly   189 SITNHITPISL--ILYEINDSLRGQQKRVALRQALSQFAPKKHEEMRQQFLV------ISAFHED 245
            |:.|.:.|:..  |:.|::   |.|:||                     ||:      |::..|.
Zfish   185 SVGNIVDPLEYRRIIEEMD---RRQEKR---------------------FLIDCEVERINSILEQ 225

  Fly   246 IIEIAETLNMFHVGNQWMIFVLDMVARDFDAGTVTINLDE----GANIAFALNETDPNCQDSLNC 306
            ::...:....:|       ::|      .:.|...::||:    ||||.
Zfish   226 VVIAGKNSRGYH-------YIL------ANLGFTNMSLDKVFSGGANIT---------------- 261

  Fly   307 TISEISLALVNAISKITVEEESIYGEISDEEW-----EAIRFTKQEKQ------AEILEYMKEFL 360
                 ...::|..|.|..:....:..:.:.|:     ..:::|.....      ||...|::...
Zfish   262 -----GFQIINPDSPIVQQFLQRWERLDEREFPESRSSPLKYTSALTHDAILVIAEAFRYLRRQR 321

  Fly   361 KTNAKCSSCARWRVETAITWGKSQENRKFRSTPQRDAKNRNFEFIN------------------- 406
            ...::..|........|:.|.:..:..:.....|......|.:|.:
Zfish   322 VDISRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDSFGRRSNYTVDVYEMKPGGA 386

  Fly   407 --IGYWTPVLGFV-CQELAFPHIEHHFRNITMDILTVHNPPWQILTKN-----SNGVIVEHKGIV 463
              ||||.....|| ..|....:......|.|:.:.|:...|:.:..:|     .|.   .::|..
Zfish   387 RKIGYWNEFEKFVYIVEQQVTNESSSVENRTIVVTTIMEAPYVMYKRNYMQLEGND---RYEGYC 448

  Fly   464 MEIVKELSRALNFSYYLH------------EASAWKEEDSLSTSAGGNESDELVGSMTFRIPYRV 516
            :::..|:::.:...|.|.            |...|               :.:||
Zfish   449 VDLASEIAKHVGIKYKLSIVADGKYGARDPETKTW---------------NGMVG---------- 488

  Fly   517 VEMVQGNQFFIAAVAATVEDPDQKPFNYTQPISVQKYSFITRKPDEVS-RIYLFTAPFTVETWFC 580
             |:|.| :..||....|:....::..::::|......|.:.:||.:.. .::.|..|...|.|.|
Zfish   489 -ELVYG-RADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMC 551

  Fly   581 LMGIILLTAPTLYAINRLAPLKEMRIVGLSTVK---------------SCFWYIFGALLQQGGMY 630
            ::...:..:..|:.::|.:|. |..:......|               :..|:..||.:|||...
Zfish   552 IVFAYIGVSVVLFLVSRFSPY-EWHLDDNEETKDPQTPPDPPNDFGIFNSLWFSLGAFMQQGCDI 615

  Fly   631 LPTADSGRLVVGFWWIVVIVLVTTYCGNLVAFLTFPKFQPGVDYLNQLEDHKDIVQYGLRNGTFF 695
            .|.:.|||:|.|.||...::::::|..||.||||..:....::....|....:|....|.:|
Zfish   616 SPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSG--- 677

  Fly   696 ERYVQSTTREDFKHYLERAKI--------YGSAQEEDI------EAVKRGERINIDWRINLQLIV 746
                  :|:|.|:    |:||        |..:.|..:      :.|.|..:....:...|:..:
Zfish   678 ------STKEFFR----RSKIAVYEKMWSYMKSAEPSVFVKTTPDGVARVRKSKGKFAFLLESTM 732

  Fly   747 QRHFEREKECHFALGRESFVDEQIAMIVPAQSAYLHLVNRHIKSMFRMGFIER-----WHQMNLP 806
            ..:.|:.|.|.......:...:...:..|..||....||..:..:...|.:::     |:
Zfish   733 NEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRTPVNLAVLKLSEQGILDKLKNKWWY----- 792

  Fly   807 SAGKCNGKSAQRQV----------TN----HKVNMDDMQGCFLVLLLGFT----LALLIVCGE 851
            ..|:|..|.:..:|          ||    ||.:.:     |.|  .|||    |.:|..|.:
Zfish   793 DKGECGTKDSGSKVSLLTHLTVLPTNISIYHKHHNE-----FPV--AGFTFFWPLFILFTCAQ 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	59/300 (20%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	63/307 (21%)
gria3a	XP_005165152.1	PBP1_iGluR_AMPA_GluR3	28..399	CDD:107382	51/336 (15%)
		ANF_receptor	39..382	CDD:279440	47/319 (15%)
		PBP2_iGluR_AMPA	415..797	CDD:270433	81/430 (19%)
		Lig_chan	547..810	CDD:278489	58/281 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591400
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940