DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and gria2b

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	XP_005157361.1	Gene:	gria2b / 170451	ZFINID:	ZDB-GENE-020125-4	Length:	897	Species:	Danio rerio

Alignment Length:	754	Identity:	150/754 - (19%)
Similarity:	276/754 - (36%)	Gaps:	182/754 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 SLRGQQKRVALRQALSQFAPKKHEEM---RQQFLVISAFHEDIIEIAETLNMFHVGNQWMIFVLD 268
            :::.::|..|.|........||...:   .:|..|     :||:|...|:.....|..::|..|.
Zfish   181 NMKDERKDEAYRSLFQDLENKKERRVILDCEQDKV-----KDIMEQVITIGRHVKGYHYIIANLG 240

  Fly   269 MVARDFDAGTVTINLDEGANIA-FALNETDPNCQDSLNCTISEISLALVNAISKITVEEESIYGE 332
            .|  |.|...:...   |||:: |.:.:.|    |.|              :||.
Zfish   241 FV--DGDLSKIQYG---GANVSGFQIVDFD----DPL--------------VSKF---------- 272

  Fly   333 ISDEEWEA------------IRFTKQ------EKQAEILEYMKE---FLKTNAKCSSCARWRVET 376
              |:.|||            ||:|..      :...|...|:.:   .:...|....|.   ...
Zfish   273 --DQRWEALEEKEYPGADSKIRYTSALTYDAVQVMTEAFRYLHKQRIDISRRANNGDCL---ANP 332

  Fly   377 AITWGKSQENRKFRSTPQRDAKNRNFEF---------------------INIGYWTPVLGFVCQE 420
            |:.|.:..|..:.....:.|....|.:|                     :.||||..|...|..:
Zfish   333 AVPWAQGVEIERALKQVRVDGLTGNIQFDQYGKRVNYTVNVMELKSNGAVKIGYWNEVDKMVVTK 397

  Fly   421 L-AFPHIEHHFRNITMDILTVHNPPWQILTKNSNGVI--VEHKGIVMEIVKELSRALNFSYYLH- 481
            . .||:......|.|:.:.|:...|:.:|.||::..:  ..::|..:::..|:::...|.|.|.
Zfish   398 SDLFPNDTMGLENKTVIVTTILEAPYVMLKKNADLFMDNERYEGYCVDLAAEIAKHCGFKYQLKI 462

  Fly   482 -----------EASAWKEEDSLSTSAGGNESDELVGSMTFRIPYRVVEMVQGNQFFIAAVAATVE 535
                       |...|               :.:||           |:|.| :..||....|:.
Zfish   463 VGDGKYGARDAETKIW---------------NGMVG-----------ELVYG-KADIAVAPLTIT 500

  Fly   536 DPDQKPFNYTQPISVQKYSFITRKPDEVS-RIYLFTAPFTVETWFCLMGIILLTAPTLYAINRLA 599
            ...::..::::|......|.:.:||.:.. .::.|..|...|.|.|::...:..:..|:.::|.:
Zfish   501 LVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFS 565

  Fly   600 P----LKEMRIVGLSTVKS--------CFWYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIVLV 652
            |    .:|.....:.|.:|        ..|:..||.::||....|.:.|||:|.|.||...::::
Zfish   566 PYEWHTEEYEDGQIQTNESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIII 630

  Fly   653 TTYCGNLVAFLTFPKFQPGVDYLNQLEDHKDIVQYGLRNGTFFERYVQSTTREDFKHYLERAKI- 716
            ::|..||.||||..:....::....|....:|....|.:|         :|:|.|:    |:||
Zfish   631 SSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSG---------STKEFFR----RSKIA 682

  Fly   717 -------YGSAQEEDI------EAVKRGERINIDWRINLQLIVQRHFEREKECHFALGRESFVDE 768
                   |....|..:      |.|.|..:....:...|:..:..:.|:.|.|.......:...:
Zfish   683 LFDKMWTYMKGAEPSVFVKTTAEGVMRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSK 747

  Fly   769 QIAMIVPAQSAYLHLVNRHIKSMFRMGFIER-----WHQMNLPSAGKCNGKSAQRQVTNHKVNMD 828
            ...:..|..|:..:.||..:..:...|.:::     |:     ..|:|.......:.....:::.
Zfish   748 GYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWY-----DKGECGSGGGDSKEKTSALSLS 807

  Fly   829 DMQGCFLVLLLGFTLALLIVCGEFWYRRFRASRKRRQFT 867
            ::.|.|.:|:.|..||:|:...||.|:. ||..||.:.|
Zfish   808 NVAGVFYILVGGLGLAMLVALVEFCYKS-RAEAKRMKVT 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	61/294 (21%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	58/290 (20%)
gria2b	XP_005157361.1	PBP1_iGluR_AMPA_GluR2	27..395	CDD:107384	48/256 (19%)
		ANF_receptor	55..377	CDD:279440	43/238 (18%)
		PBP2_iGluR_AMPA	410..790	CDD:270433	83/424 (20%)
		Lig_chan	542..820	CDD:278489	59/295 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591390
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940