DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir93a and Grin2c

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	XP_017169765.1	Gene:	Grin2c / 14813	MGIID:	95822	Length:	1307	Species:	Mus musculus

Alignment Length:	834	Identity:	157/834 - (18%)
Similarity:	291/834 - (34%)	Gaps:	220/834 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 VVFVDQTILEENALL---VKSIVHESITNHITPISLILYEINDSLRGQQKRVALRQALSQFAPKK 228
            :||.|....|..|.|   |.|..|..|.:.....:::|..........|..|:|.|.|.......
Mouse   155 IVFEDNVDTEAVAQLLDFVSSQTHVPILSISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVL 219

  Fly   229 HEEMRQQFLVISAFH-------EDIIEIAETLNMFHVGNQWMIFVLDMVARDFDAG-------TV 279
            .|.....|.||::.|       |.:..:|:...:     .|.:  ||::..:...|       .:
Mouse   220 EEYDWSAFAVITSLHPGHALFLEGVRAVADASYL-----SWRL--LDVLTLELGPGGPRARTQRL 277

  Fly   280 TINLDEGANIAFALNETD---------------------PNCQDSLNCTISEISLALVNAISKIT 323
            ...:|....:|:...|..                     ||.  :|..|.:..:...|..||.:|
Mouse   278 LRQVDAPVLVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNL--ALGSTDAPPAAFPVGLISVVT 340

  Fly   324 VEEESIYGEISDEEWEAIRFTKQEKQAEIL-----EYMKEFLKTNAKCSSC------------AR 371
                        |.|......|......||     .|.:::....|....|            |.
Mouse   341 ------------ESWRLSLRQKVRDGVAILALGAHSYRRQYGTLPAPAGDCRSHPGPVSPAREAF 393

  Fly   372 WRVETAITWGKSQENRKFRSTPQR---------DAKNRNFEFINIGYWT--------PVLGFVCQ 419
            :|....:||    |.|.|..:|..         .|.||:..:..:|.|.        ||......
Mouse   394 YRHLLNVTW----EGRDFSFSPGGYLVQPTMVVIALNRHRLWEMVGRWDHGVLYMKYPVWPRYST 454

  Fly   420 ELAFPHIEHHFRNITMDILTVHNPPWQILTKN----------------------SNGVIVEH--- 459
            .|. |.::.  |::|  :.|:...|:.|:...                      |:|.|..:
Mouse   455 SLQ-PVVDS--RHLT--VATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDITPYTKL 514

  Fly   460 --KGIVMEIVKELSRALNFSYYLHEASAWKEEDSLSTSAGGNESDELVGSMTFRIPYRVVEMVQG 522
              ||..::|:|:|::.:.|||.|:..:..|.         |.....:...|...:.|:..:|..|
Mouse   515 CCKGFCIDILKKLAKVVKFSYDLYLVTNGKH---------GKRVRGVWNGMIGEVYYKRADMAIG 570

  Fly   523 NQFFIAAVAATVEDPDQKPFNYTQPISVQKYSFITRKPDEVSRIYLFTAPFTVETWFCLMGIILL 587
                    :.|:.:...:..:::.|......|.:..:.:.......|..|::...| .:|.::.|
Mouse   571 --------SLTINEERSEIIDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVW-VMMFVMCL 626

  Fly   588 T--APTLYAINRLAPL-------KEMRIVGLS-TVKSCFWYIFGALLQQGGMYL--PTADSGRLV 640
            |  |.|::.....:|:       |..:..|.| |:....|.:: ||:....:.:  |...:.:::
Mouse   627 TVVAITVFMFEYFSPVSYNQNLTKGKKSGGPSFTIGKSVWLLW-ALVFNNSVPIENPRGTTSKIM 690

  Fly   641 VGFWWIVVIVLVTTYCGNLVAFLTFPKFQPGVDYLNQLEDHK-----DIVQY-GLRNGTF----F 695
            |..|....::.:.:|..||.||:...::   :|.::.|.|.|     |  || ..|.||.    .
Mouse   691 VLVWAFFAVIFLASYTANLAAFMIQEQY---IDTVSGLSDKKFQRPQD--QYPPFRFGTVPNGST 750

  Fly   696 ERYVQSTTREDFKHYLERAKIYGSAQEEDIEAVKRGERINIDWRINLQLIVQRHFEREKEC---- 756
            ||.::|..|:...|.:   |....:.|:.:.::|.|               .||..|:.:.
Mouse   751 ERNIRSNYRDMHTHMV---KFNQRSVEDALTSLKMG---------------ARHVSRKLDAFIYD 797

  Fly   757 ----HFALGRES------------FVDEQIAMIVPAQSAYLHLVNRHIKSMFRMGFIERWHQMNL 805
                ::..|::.            |......:.:...|.:...::..:......|..::...:.|
Mouse   798 AAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWL 862

  Fly   806 PSAGKCNGKSAQRQVTNHKVNMDDMQGCFLVLLLGFTLALLIVCGE---FWYRR 856
              :|.|:.:  :.:|.:.|:::|:|.|.|.:||:...||||:...|   :|..|
Mouse   863 --SGICHNE--KNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLR 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	60/316 (19%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	57/301 (19%)
Grin2c	XP_017169765.1	PBP1_iGluR_NMDA_NR2	90..446	CDD:380601	59/315 (19%)
		PBP2_iGluR_NMDA_Nr2	462..868	CDD:270436	79/453 (17%)
		NMDAR2_C	905..>980	CDD:371139	2/8 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846434
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930