DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and Grin2a

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_032196.2	Gene:	Grin2a / 14811	MGIID:	95820	Length:	1464	Species:	Mus musculus

Alignment Length:	818	Identity:	154/818 - (18%)
Similarity:	312/818 - (38%)	Gaps:	176/818 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 ALMVPIVENGDEFPQLILDAKVQQILNWK--TAVVFVDQTILEENALLVKSIVHE------SITN 192
            |.|:..:.:....|.|.:......|:..|  |:..|.....:::.|.::..|:.:      |:..
Mouse   110 AQMLDFISSQTFIPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVT 174

  Fly   193 HITP-----ISLILYEINDSLRG--QQKRVAL----RQALSQFAPKK-HEEMRQQFLVISAFHED 245
            .|.|     ||.|...:::|..|  .|..:.|    ..|.:|...|| |..:   .|:..:..|.
Mouse   175 TIFPGYRDFISFIKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSV---ILLYCSKDEA 236

  Fly   246 IIEIAETLNMFHVGNQ--WMIFVL-----DMVARDFDAGTVTINLDEGANIAFALNETDPNCQDS 303
            ::.::|..::...|..  |::..|     :::.::|.:|.::::.|:.   .::|   :...:|.
Mouse   237 VLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDW---DYSL---EARVRDG 295

  Fly   304 LNCTISEISLALVNAISKITVEEESIYGEISDEEWEAIRFTKQEKQAEILEYMKEFLKTNAKCSS 368
            |....:..| :::...|.|...:.|.||:             .||....|..:.:|:
Mouse   296 LGILTTAAS-SMLEKFSYIPEAKASCYGQ-------------TEKPETPLHTLHQFM-------- 338

  Fly   369 CARWRVETAITW-GK----SQENRKFRSTPQRDAKNRNFEFINIGYWTPVLGFVCQELAFPHI-- 426
                   ..:|| ||    ::|..:..........|::.|:..:|.|..      |.|:..|.
Mouse   339 -------VNVTWDGKDLSFTEEGYQVHPRLVVIVLNKDREWEKVGKWEN------QTLSLRHAVW 390

  Fly   427 ------------EHHFRNITM-----------DILT---VHNP-PWQILTKNSN----GVIVEH- 459
                        ::|...:|:           |.||   |.|. |.:...|.:|    |:.|:.
Mouse   391 PRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKC 455

  Fly   460 -KGIVMEIVKELSRALNFSYYLHEASAWKEEDSLSTSAGGNESDELVGSMTFRIPYRVVEMVQGN 523
             ||..::|:|:|||.:.|:|.|:..:..|.         |.:.:.:...|...:.|:...|..|
Mouse   456 CKGFCIDILKKLSRTVKFTYDLYLVTNGKH---------GKKVNNVWNGMIGEVVYQRAVMAVG- 510

  Fly   524 QFFIAAVAATVEDPDQKPFNYTQP-----ISVQKYSFITRKPDEVSRIYLFTAPFTVETWFCLMG 583
                   :.|:.:...:..:::.|     |||    .::|....||. ..|..||:...|..:..
Mouse   511 -------SLTINEERSEVVDFSVPFVETGISV----MVSRSNGTVSP-SAFLEPFSASVWVMMFV 563

  Fly   584 IILL-TAPTLYAINRLAPLKEMRIVGLS--------TVKSCFWYIFGALLQQG-GMYLPTADSGR 638
            ::|: :|..::.....:|:...|.:...        |:....|.::|.:.... .:..|...:.:
Mouse   564 MLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSK 628

  Fly   639 LVVGFWWIVVIVLVTTYCGNLVAFLTFPKFQPGVDYLNQLEDHK-----DIVQYG--LRNGTFFE 696
            ::|..|....::.:.:|..||.||:...:|   ||.:..|.|.|     |   |.  .|.||...
Mouse   629 IMVSVWAFFAVIFLASYTANLAAFMIQEEF---VDQVTGLSDKKFQRPHD---YSPPFRFGTVPN 687

  Fly   697 RYVQSTTREDFKHYLER--AKIYGSAQEEDIEAVKRGERINIDWRINLQLIVQRHFEREKECHFA 759
            ...:...|.::. |:.:  .|......|:.:.::|.|:   :|..|....::.....|::.|...
Mouse   688 GSTERNIRNNYP-YMHQYMTKFNQRGVEDALVSLKTGK---LDAFIYDAAVLNYKAGRDEGCKLV 748

  Fly   760 LGRESFVDEQIAMIVPAQ--SAYLHLVNRHIKSMFRMGFIERWHQMNLPSAGKCNGKSAQRQVTN 822
            .....::.......:..|  |.:...::..:......|.:|....:.|  .|.|:.:  :.:|.:
Mouse   749 TIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWL--TGICHNE--KNEVMS 809

  Fly   823 HKVNMDDMQGCFLVLLLGFTLALLIVCGE---FWYRRF 857
            .::::|:|.|.|.:|.....|:|:....|   :|..||
Mouse   810 SQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRF 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	66/310 (21%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	49/280 (18%)
Grin2a	NP_032196.2	PBP1_iGluR_NMDA_NR2	32..392	CDD:107373	59/325 (18%)
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	83/432 (19%)
		HisJ	<458..>541	CDD:223904	21/103 (20%)
		Lig_chan	556..828	CDD:278489	50/285 (18%)
		NMDAR2_C	839..1464	CDD:287527	3/9 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846416
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930