DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and Grik5

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	XP_030098003.1	Gene:	Grik5 / 14809	MGIID:	95818	Length:	1003	Species:	Mus musculus

Alignment Length:	992	Identity:	200/992 - (20%)
Similarity:	352/992 - (35%)	Gaps:	281/992 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PSACLLLLAGLQLSILVPTEANDFSSFLSANASLAVVVDHEYMTVHGENILAHFEKILSDVIREN 72
            |:..|||        |:...||.....|| :..:|.::|.:  ||.|..     |::...:.||.
Mouse     2 PAELLLL--------LIVAFANPSCQVLS-SLRMAAILDDQ--TVCGRG-----ERLALALAREQ 50

  Fly    73 LRNGGINVKYFSWNAVRLKKDFLAAITVTDCENTWNFYKNTQ-ETSILLIAITDSDCPRLPLNRA 136
            : ||.|.|.    ...|::.|.            :...:::| ||       ||:.|..||
Mouse    51 I-NGIIEVP----AKARVEVDI------------FELQRDSQYET-------TDTMCQILP---- 87

  Fly   137 LMVPIVENGDEFPQLILDAKVQQILNWKTAVVFVDQTILEENALLVKSIVHESITNHI------T 195
                                       |..|..:..:....:|..|..|..|....||      |
Mouse    88 ---------------------------KGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPEET 125

  Fly   196 P-------ISLILYEINDSLRGQQKRVALRQALSQF-APKKHEEMRQQFLVISAFHEDIIEIAET 252
            |       .|:.||..|:.:     .:|:.:.|..| .|...        :|.|..|.::.:.|.
Mouse   126 PRLQYLRFASVSLYPSNEDV-----SLAVSRILKSFNYPSAS--------LICAKAECLLRLEEL 177

  Fly   253 LNMFHVGNQWM-IFVLD-------MVARDFDAGTVTINLDEGANIA-----FALNETDP-----N 299
            :..|.:..:.: :.:||       ::....|....||.:|..|:|:     .:||.:.|     :
Mouse   178 VRGFLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLVLRLSLNLSSPLGFPRS 242

  Fly   300 CQDSLNCTISEISLALVNAISKI--------------TVEEES-------------IYGEIS--- 334
            ....|:|.:....|.:.:|..|.              .||:.|             .|.|..
Mouse   243 LPLGLSCVLQASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSL 307

  Fly   335 ----DEEWEAIRFTKQEKQAE--------ILEYMKEFLKTN------AKCSSCARWRVETAI--- 378
                .|..||..:......|.        ::..::|..::.      ..|:|...|...|::
Mouse   308 NMSWRENCEASTYPGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNY 372

  Fly   379 --------TWGKSQENRKFRSTPQR----DAKNRNFEFINIGYWTPVLGFVCQELAFPHIEHHFR 431
                    ..|:.:.|.|.:.|...    :...:....|.:.|....|......|.. ::.....
Mouse   373 LRMVEYDGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDI-NLSQTLA 436

  Fly   432 NITMDILTV-------HNPPWQILTKNSNGVIVEHKGIVMEIVKELSRALNFSYYLHEASAWKEE 489
            |.|:.:.|:       ..|.:|.|:.|.     ..:|..:::::||:..|.|.|.|...     |
Mouse   437 NKTLVVTTILENPYVMRRPNFQALSGNE-----RFEGFCVDMLRELAELLRFRYRLRLV-----E 491

  Fly   490 DSLSTSAGGNESDELVGSMTFRIPYRVVEMVQGNQFFIAAVAATVEDPDQKPFNYTQP-----IS 549
            |.|..:...|      ||.|    ..|.|::...:..:|..|.|:....:|..::::|     ||
Mouse   492 DGLYGAPEPN------GSWT----GMVGELINRQKADLAVAAFTITAEREKVIDFSKPFMTLGIS 546

  Fly   550 VQKYSFITRKPDEVSRIYLFTAPFTVETWFCLMGIILLTAPTLYAINRLAPLKEMR--------- 605
            :.....:.|||...|    |..||:...|..::...|..:..|:...||:|.:...
Mouse   547 ILYRVHMGRKPGYFS----FLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARP 607

  Fly   606 --IVGLSTVKSCFWYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIVLVTTYCGNLVAFLTFPKF 668
              :....|:.:..|:..|..:|||...:|.|.|.|.|.|.||...::::::|..||.||||..:.
Mouse   608 HILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRM 672

  Fly   669 QPGVDYLNQLEDHKDIVQYGLRNG----TFFE--RYVQSTTREDFKHYLE--RAKIYGSAQEEDI 725
            :..|:..:.|.|..:| :||..:.    |||:  ||   .|.:...:|::  :..::..:.||.|
Mouse   673 EVPVESADDLADQTNI-EYGTIHAGSTMTFFQNSRY---QTYQRMWNYMQSKQPSVFVKSTEEGI 733

  Fly   726 EAVKRGERINIDWRINLQLIVQRHFEREKECH------------FALGR---ESFVDEQIAMIVP 775
            ..|     :|..:...|: .....:.|...|:            :.:|.   ..|.||....|:.
Mouse   734 ARV-----LNSRYAFLLE-STMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQ 792

  Fly   776 AQSAYLHLVNRHIKSMFRMGFIERWHQMNLPSAGKCNGKSAQRQVTNHKVNMDDMQGCFLVLLLG 840
            .|.      |..::.:.|     :|.:     .|:|..:...|.   ..:.|:::.|.|:||:.|
Mouse   793 LQE------NNRLEILKR-----KWWE-----GGRCPKEEDHRA---KGLGMENIGGIFVVLICG 838

  Fly   841 FTLALLIVCGEF-WYRR 856
            ..:|:.:...|| |..|
Mouse   839 LIIAVFVAVMEFIWSTR 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	73/296 (25%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	63/293 (22%)
Grik5	XP_030098003.1	PBP1_iGluR_Kainate_KA1_2	23..424	CDD:380616	82/475 (17%)
Grik5	XP_030098003.1	Periplasmic_Binding_Protein_Type_2	437..808	CDD:419667	94/415 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846440
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840