Protein Alignment Ir93a and Grik3

DIOPT Version :10

• Sequence 1: NP_650924.3
• Gene: Ir93a / 42471
• FlyBaseID: FBgn0259215
• Length: 868
• Species: Drosophila melanogaster
• Sequence 2: NP_001074566.1
• Gene: Grik3 / 14807
• MGIID: 95816
• Length: 919
• Species: Mus musculus
• Alignment Length: 880
• Identity: 181/880 - (20%)
• Similarity: 337/880 - (38%)
• Gaps: 179/880 - (20%)

  Fly    83 FSWNAVRLKKDFLAAITVTDCENTWNFYKNTQET-------SILLIAI---TDSDCPRL--PLNR 135
            ||.|.:...:..|...|:|......:|:.:.:.|       ::.::||   :...|...  .:..
Mouse    62 FSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICN 126

  Fly   136 ALMVPIV---------ENGDEF-----------PQLILDAKVQQILNWKTA-VVFVDQTILEENA 179
            ||.||.:         :|.|.|           ...|||  :.|.|.|::| ||:.|.|.|   .
Mouse   127 ALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILD--LVQSLKWRSATVVYDDSTGL---I 186

  Fly   180 LLVKSIVHESITNHITPISLILYEINDSLRGQQKRVALRQALSQFAPKKHEEMRQQFLVISAFHE 244
            .|.:.|:..|..|....|..:..:.:||          |..|.:.  |:..|.|..|........
Mouse   187 RLQELIMAPSRYNIRLKIRQLPIDSDDS----------RPLLKEM--KRGREFRIIFDCSHTMAA 239

  Fly   245 DIIEIAETLNMFHVGNQWMIFVLDMVARDFD---------AGTVTINLDE---GANI---AFALN 294
            .|::.|..:.|......::...||:.|.|.:         .|...:|:|.   .|.:   |....
Mouse   240 QILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWAMERL 304

  Fly   295 ETDPNCQDSLNCTISEISLALV-NAISKITV----EEESIYGEISDEEWEAIRFTKQEKQAEILE 354
            :..|..:..|...:.....||: :|:..::|    ..:.....:.....:|.||     ....:.
Mouse   305 QAAPRAESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRF-----GGRFMN 364

  Fly   355 YMKEFLKTNAKCSSCARWRVETA-ITWGKSQENRKFRSTPQRDAKNRNFEFINIGYWTPVLGFVC 418
            ::||           |:|...|. |.:.|:...|..........|....|  .:|.|:|..|...
Mouse   365 FIKE-----------AQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLE--KVGVWSPADGLNI 416

  Fly   419 QELA---FPHIEHHFRNITMDILTVHNPPWQILTKNSNGVIVEHK--GIVMEIVKELSRALNFSY 478
            .|:|   .|::.....|.::.:.||...|:.:..|:...:....:  |..::::|||:..|.|||
Mouse   417 TEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSY 481

  Fly   479 YLH--EASAWKEEDSLSTSAGGNESDELVGSMTFRIPYRVVEMVQGNQFFIAAVAATVEDPDQKP 541
            .:.  |...:..:|......|                 .|.|::. ::..:|....|:....:|.
Mouse   482 EIRLVEDGKYGAQDDKGQWNG-----------------MVKELID-HKADLAVAPLTITHVREKA 528

  Fly   542 FNYTQPISVQKYSFITRKPDEVS-RIYLFTAPFTVETWFCLMGIILLTAPTLYAINRLAPLK--- 602
            .::::|......|.:.|||:..: .::.|..|.:.:.|..::...|..:..|:.|.|.:|.:
Mouse   529 IDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYD 593

  Fly   603 --------EMRIVGLSTVKSCFWYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIVLVTTYCGNL 659
                    |: :....|:.:.||:..|:|:|||...:|.|.|.|::.|.||...::::::|..||
Mouse   594 AHPCNPGSEV-VENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANL 657

  Fly   660 VAFLTFPKFQPGVDYLNQLEDHKDIVQYG-LRNG---TFFERYVQSTTREDFKHYLERAKIYGSA 720
            .||||..:.:..:|..:.|.....| :|| :::|   |||::...||..:.:.....:.......
Mouse   658 AAFLTVERMESPIDSADDLAKQTKI-EYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKN 721

  Fly   721 QEEDIEAVKRGERINIDWRINLQLIVQRHFEREKECHFA-LGRESFVDEQ--------------- 769
            .||.|:.....:...:.....::.|.||:      |:.. :|  ..:|.:
Mouse   722 NEEGIQRTLTADYALLMESTTIEYITQRN------CNLTQIG--GLIDSKGYGIGTPMGSPYRDK 778

  Fly   770 --IAMIVPAQSAYLHLVNRHIKSMFRMGFIERWHQMNLPSAGKCNGKSAQRQVTNHKVNMDDMQG 832
              ||::...:...||::.            |:|        .:.:|...:.......:.:..:.|
Mouse   779 ITIAILQLQEEDKLHIMK------------EKW--------WRGSGCPEEENKEASALGIQKIGG 823

  Fly   833 CFLVLLLGFTLALLIVCGEFWYR-RFRASRKRRQF 866
            .|:||..|..|::|:..|||.|: |..|.|::|.|
Mouse   824 IFIVLAAGLVLSVLVAVGEFIYKLRKTAEREQRSF 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:473866	66/287 (23%)
		Lig_chan	574..836	CDD:459656	58/294 (20%)
Grik3	NP_001074566.1	PBP1_iGluR_Kainate	37..417	CDD:380605	78/389 (20%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	83/415 (20%)