DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and Grik2

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	XP_011241422.1	Gene:	Grik2 / 14806	MGIID:	95815	Length:	943	Species:	Mus musculus

Alignment Length:	959	Identity:	188/959 - (19%)
Similarity:	347/959 - (36%)	Gaps:	267/959 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 LRNGGINVKY--------------FSWNAVRLKKDFLAAITVTDCENTWNFY-------KNTQET 116
            ||.||| .:|              |:.|.:...:..|...|:|......|.|       |...:.
Mouse    36 LRFGGI-FEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQL 99

  Fly   117 SILLIAI-----------TDSDCPRLPLNRALMVP---------IVENGDEF-----------PQ 150
            |:.:.||           ..|.|      .||.||         :.:|.|.|           .:
Mouse   100 SLGVAAIFGPSHSSSANAVQSIC------NALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSR 158

  Fly   151 LILDAKVQQILNWKT-AVVFVDQTILEENALLVKSIVHESITNHITPISLILYEINDSLRGQQKR 214
            .|||  :.|...||| .||:.|.|.|.....|:|:....::                       |
Mouse   159 AILD--LVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNL-----------------------R 198

  Fly   215 VALRQ--ALSQFAPKKHEEMR--QQFLVI-SAFHE---DIIEIAETLNMFHVGNQWMIFVLDMVA 271
            :.:||  |.::.|....:||:  ::|.|| ...||   .|::.|..:.|......::...||:.|
Mouse   199 LKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFA 263

  Fly   272 RDFDAGTVTINLDEGANI-AFALNETDPNCQDSLNCTISEISLALVNAISK---------ITVEE 326
            .|.:....:     |.|: .|.:..|: |.|  ::..|.:.|:..:.|..|         :|.:.
Mouse   264 LDVEPYRYS-----GVNMTGFRILNTE-NTQ--VSSIIEKWSMERLQAPPKPDSGLLDGFMTTDA 320

  Fly   327 ESIYGEISDEEWEAIRFTKQEKQAEILEYMKEFLKTNAKCSSCARWRVET--------------- 376
            ..:|        :|:...     :..::...:...::.:|:....||..|
Mouse   321 ALMY--------DAVHVV-----SVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLT 372

  Fly   377 -AITWGKSQENRKFRSTPQRDAKNRNFEFINIGYWTPVLGF---VCQELAFPHIEHHFRNITMDI 437
             .||:.|:...|..........|....|  .||.|.|..|.   ..|:....:|.....|.::.:
Mouse   373 GRITFNKTNGLRTDFDLDVISLKEEGLE--KIGTWDPSSGLNMTESQKGKPANITDSLSNRSLIV 435

  Fly   438 LTVHNPPWQILTKNSNGVIV---EHKGIVMEIVKELSRALNFSYYLH--EASAWKEEDSLSTSAG 497
            .|:...|: :|.|.|:..:.   ..:|..:::::|||..|.|:|.:.  |...:..:|.::....
Mouse   436 TTILEEPY-VLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWN 499

  Fly   498 GNESDELVGSMTFRIPYRVVEMVQGNQFFIAAVAATVEDPDQKPFNYTQPISVQKYSFITRKPDE 562
            |                .|.|::. ::..:|.....:....:|..::::|......|.:.|||:.
Mouse   500 G----------------MVRELID-HKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNG 547

  Fly   563 VS-RIYLFTAPFTVETWFCLMGIILLTAPTLYAINRLAPLKEMRIVGLS---------------- 610
            .: .::.|..|.:.:.|..::...|..:..|:.|.|.:.....:....|
Mouse   548 TNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARQSKFSWFKYPNCSHYHHSQRCLCTQHLES 612

  Fly   611 -----------------------------TVKSCFWYIFGALLQQGGMYLPTADSGRLVVGFWWI 646
                                         |:.:.||:..|||:|||...:|.|.|.|:|.|.||.
Mouse   613 YMELCLFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWF 677

  Fly   647 VVIVLVTTYCGNLVAFLTFPKFQPGVDYLNQLEDHKDIVQYG-LRNG---TFFERYVQSTTREDF 707
            ..::::::|..||.||||..:.:..:|..:.|.....| :|| :.:|   |||::...||..:.:
Mouse   678 FTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKI-EYGAVEDGATMTFFKKSKISTYDKMW 741

  Fly   708 KHYLERAK-IYGSAQEEDIEAVKRGERINIDWRINLQLIVQRHFEREKECHFA-LGRESFVDEQ- 769
            .....|.: :...:.||.|:.|...:...:.....::.:.||:      |:.. :|  ..:|.:
Mouse   742 AFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRN------CNLTQIG--GLIDSKG 798

  Fly   770 ----------------IAMIVPAQSAYLHLVNRHIKSMFRMGFIERWHQMNLPSAGKCNGKSAQR 818
                            ||::...:...||::.            |:|        .:.||...:.
Mouse   799 YGVGTPMGSPYRDKITIAILQLQEEGKLHMMK------------EKW--------WRGNGCPEEE 843

  Fly   819 QVTNHKVNMDDMQGCFLVLLLGFTLALLIVCGEFWYR-RFRASRKRRQF 866
            ......:.:.::.|.|:||..|..|::.:..|||.|: :..|..::|.|
Mouse   844 SKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSF 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	66/322 (20%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	61/327 (19%)
Grik2	XP_011241422.1	PBP1_iGluR_Kainate	37..414	CDD:380605	86/431 (20%)
Grik2	XP_011241422.1	Periplasmic_Binding_Protein_Type_2	430..835	CDD:389745	84/451 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846436
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840