DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and Grik1

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	XP_006522977.1	Gene:	Grik1 / 14805	MGIID:	95814	Length:	949	Species:	Mus musculus

Alignment Length:	956	Identity:	186/956 - (19%)
Similarity:	343/956 - (35%)	Gaps:	271/956 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 IRENLRNGGINVKYFSWNAVRLKKDFLAAITVTDCENTWNFYKNTQET-SILLIAITDS------ 126
            |.|.:.|..:||:..::.           ..||..........||..| .|..|.:.||
Mouse    42 IFETVENEPVNVEELAFK-----------FAVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRR 95

  Fly   127 DCPRLPLNRALMV-----------------------------PIVENGDEF-----------PQL 151
            .|.:|.|..|.:.                             |.|:|.|.|           .:.
Mouse    96 ACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNRDLFYINLYPDYAAISRA 160

  Fly   152 ILDAKVQQILNWKT-AVVFVDQTILEENALLVKSIVHESITNHITPISLILYEINDSLRGQQKRV 215
            :||..:  ..|||| .||:.|.|.|.....|:|:....:|                       ::
Mouse   161 VLDLVL--YYNWKTVTVVYEDSTGLIRLQELIKAPSRYNI-----------------------KI 200

  Fly   216 ALRQALS---QFAP--KKHEEMRQQFLVISAFHEDIIEIAETL-------NMFHVGNQWMIFVLD 268
            .:||..|   ...|  |:.::.::.:::....||...||.:.:       ..:|    :....||
Mouse   201 KIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYH----YFFTTLD 261

  Fly   269 MVARDFD---------AGTVTINLDEGANIAFALN-------ETDPNCQDSLNCTISEISLALV- 316
            :.|.|.:         .|...:|:| ..:::..:.       :..|..:..|...:.....||:
Mouse   262 LFALDLELYRYSGVNMTGFRLLNID-NPHVSSIIEKWSMERLQAPPRPETGLLDGVMTTEAALMY 325

  Fly   317 NAISKITVEEESIYGEISDEEWEAIRFTKQEKQAEILEYMKEFLKTNAKCSSCARWRVETA-ITW 380
            :|:..:.:..... .:::....:..|..........:..:||           |||...|. ||:
Mouse   326 DAVYMVAIASHRA-SQLTVSSLQCHRHKPWRLGPRFMNLIKE-----------ARWDGLTGRITF 378

  Fly   381 GKSQENRK-----FRSTPQRDAKNRNFE--------FINIGYWTPVLGF------------VCQE 420
            .|:...||     ..|..:...:..:.|        :..||.|....|.            :...
Mouse   379 NKTDGLRKDFDLDIISLKEEGTEKASGEVSKHLYKVWKKIGIWNSNSGLNMTDGNRDRSNNITDS 443

  Fly   421 LAFPHIEHHFRNITMDILTVHNPPWQILTKNSNGVIVEHK--GIVMEIVKELSRALNFSYYLHEA 483
            ||         |.|:.:.|:...|:.:..|:...:....:  |..::::||||..|.|.|.:...
Mouse   444 LA---------NRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLV 499

  Fly   484 SAWKEEDSLSTSAGGNESDELVGSMTFRIPYRVVEMVQGNQFFIAAVAATVEDPDQKPFNYTQPI 548
            ...|       ....|:..|..|.:...|.:|.         .:|....|:....:|..::::|.
Mouse   500 PDGK-------YGAQNDKGEWNGMVKELIDHRA---------DLAVAPLTITYVREKVIDFSKPF 548

  Fly   549 SVQKYSFITRKPDEVS-RIYLFTAPFTVETWFCLMGIILLTAPTLYAINRLAPLK---------E 603
            .....|.:.|||:..: .::.|..|.:.:.|..::...|..:..|:.|.|..|.:         :
Mouse   549 MTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPD 613

  Fly   604 MRIVGLS-TVKSCFWYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIVLVTTYCGNLVAFLTFPK 667
            ..:|..: |:.:.||:..|||:|||...:|.|.|.|:|.|.||...::::::|..||.||||..:
Mouse   614 SDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVER 678

  Fly   668 FQPGVDYLNQLEDHKDIVQYG-LRNG---TFFERYVQSTTREDFKHYLERAKIYGSA----QEED 724
            .:..:|..:.|.....| :|| :|:|   |||::...||..:.:.....|.:   ||    .:|.
Mouse   679 MESPIDSADDLAKQTKI-EYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQ---SALVKNSDEG 739

  Fly   725 IEAVKRGERINIDWRI-----NLQLIVQRHFEREKECHFA-LGRESFVDEQ-------------- 769
            |:.|     :..|:.:     :::.:.||:      |:.. :|  ..:|.:
Mouse   740 IQRV-----LTTDYALLMESTSIEYVTQRN------CNLTQIG--GLIDSKGYGVGTPIGSPYRD 791

  Fly   770 ---IAMIVPAQSAYLHLVNRHIKSMFRMGFIERWHQMNLPSAGKCNGKSAQRQVTNHKVNMDDMQ 831
               ||::...:...||::.            |:|        .:.||...:.......:.::::.
Mouse   792 KITIAILQLQEEGKLHMMK------------EKW--------WRGNGCPEEDSKEASALGVENIG 836

  Fly   832 GCFLVLLLGFTLALLIVCGEFWYR---------RFRASRKRRQFTN 868
            |.|:||..|..|::.:..|||.|:         :.::||.|..|.|
Mouse   837 GIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIEQKGKSSRLRFYFRN 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	70/284 (25%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	65/300 (22%)
Grik1	XP_006522977.1	PBP1_iGluR_Kainate	38..431	CDD:380605	77/441 (17%)
Grik1	XP_006522977.1	Periplasmic_Binding_Protein_Type_2	446..815	CDD:389745	90/421 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846424
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840