DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and Grid1

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_032192.2	Gene:	Grid1 / 14803	MGIID:	95812	Length:	1009	Species:	Mus musculus

Alignment Length:	944	Identity:	172/944 - (18%)
Similarity:	352/944 - (37%)	Gaps:	227/944 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 MTVHGENILAHFEKILSDVIRENLRNGGINVKYFSWNAVRLKKDFLA-AITVTDCENTWNFYKNT 113
            :||..::|: |...|..:...::.|...:.|...|.|...|:.:.:. :|.|.:..|.   ::..
Mouse    16 VTVRADSII-HIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNP---FQAV 76

  Fly   114 QE-----TSILLIAITDSDCPRL----PLNRALMVPIV-------------------ENGDEF-- 148
            ||     |..:|..:|.:.|...    .|..|:.:|.:                   .:|:.:
Mouse    77 QEACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTL 141

  Fly   149 ----PQLILDAKVQQI--LNWKTAVVFVD--------QTILEENALLVKSIVHESITNHITPISL 199
                |..:.|..::.:  |.|:..|:|.|        |:.|::.:.|...:..:.:..:|:.:..
Mouse   142 ASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFT 206

  Fly   200 ILYEINDSLRGQQKRVALRQALSQFAPKKHEEMRQQFLVISAFHEDIIEIAETLNMFHVGNQWMI 264
            .|:....:....:.|..||:|:...:|:             ..|..|.|..|| |:....:.|:.
Mouse   207 SLFTTMKTEELNRYRDTLRRAILLLSPQ-------------GAHSFINEAVET-NLASKDSHWVF 257

  Fly   265 F--------VLDMVARDFDAGTVTINLDEGANIAFALNETDPNCQDSLNCT-------------- 307
            .        :||:|....  |.:|:           :.:..|:.:|:..|.
Mouse   258 VNEEISDPEILDLVHSAL--GRMTV-----------VRQIFPSAKDNQKCMRNNHRISSLLCDPQ 309

  Fly   308 ---ISEISLALVNAISKITVEEESIYGEISDEEWEAIRFTKQEKQAEILEYMKEFLKTNAKCSSC 369
               :..:.::.:.....:.:...:.:.::.|.:|.::        |.:               :|
Mouse   310 EGYLQMLQISNLYLYDSVLMLANAFHRKLEDRKWHSM--------ASL---------------NC 351

  Fly   370 ARWRVETAITW--GKSQEN-------------RKFRSTPQRDAKNRNFEFINIG-YWTPVLGFVC 418
            .|   ::...|  |:|..:             .:||    .|:.|...:|..:| .::...|...
Mouse   352 IR---KSTKPWNGGRSMLDTIKKGHITGLTGVMEFR----EDSSNPYVQFEILGTTYSETFGKDM 409

  Fly   419 QELAFPHIE-------------HHFRNITMDILTVHNPPWQILTKNSNGVIVEHKGIVMEIVKEL 470
            ::||....|             ...:.:|:.::||...|:.::.:|..|....:||..::::..|
Mouse   410 RKLATWDSEKGLNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRYKGFSIDVLDAL 474

  Fly   471 SRALNFSYYLHEASAWKEEDSLSTSAGGNESDELVGSMTFRIPYRVVEMVQGNQFFIAAVAATVE 535
            ::||.|.|.:::|...:....|..::......||:....              ...|:|:..|.|
Mouse   475 AKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRA--------------DLAISAITITPE 525

  Fly   536 -----DPDQKPFNYTQPISVQKYSFITRKPDEVSRIYLFTAPFTVETWFCLMGIILLTAPTLYAI 595
                 |..::..:|:..|       :.:||:|...|:...|||....|.|:...|.:....::.:
Mouse   526 RESVVDFSKRYMDYSVGI-------LIKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVL 583

  Fly   596 NRLAPLK-----EMRIVGLSTVKSCFWYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIVLVTTY 655
            ||:..::     :.|....:|:.|..|.::||.:||||.....:.:.|:|:|.||:..:::.::|
Mouse   584 NRIQAVRSQSATQPRPSASATLHSAIWIVYGAFVQQGGESSVNSVAMRIVMGSWWLFTLIVCSSY 648

  Fly   656 CGNLVAFLTFPKFQPGV----DYLNQLEDHKDIVQYG-LRNGTFFERYVQSTTREDFKHYLERAK 715
            ..||.||||..:....:    |...|||     :.|| :|:...:|.:....|..     ||:..
Mouse   649 TANLAAFLTVSRMDNPIRTFQDLSKQLE-----MSYGTVRDSAVYEYFRAKGTNP-----LEQDS 703

  Fly   716 IYG----------------SAQEEDIEAVKRGERINIDWRINLQLIVQRHFEREKECHFALGRES 764
            .:.                |...|.|...|:|....: |.:   .:|:.....:.:|...:...|
Mouse   704 TFAELWRTISKNGGADNCVSNPSEGIRKAKKGNYAFL-WDV---AVVEYAALTDDDCSVTVIGNS 764

  Fly   765 FVDEQIAMIVPAQSAYLHLVNRHIKSMFRMGFIERWHQMNLPSAGKCNGKS-AQRQVTNHKVNMD 828
            ...:...:.:...|.|..|.::.|..:...|.::...|...|..|:|:..| :..|.....:.:.
Mouse   765 ISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHTGRCDLTSHSSTQTEGKSLKLH 829

  Fly   829 DMQGCFLVLLLGFTLALLIVCGEFWYRRFRASRK 862
            ...|.|.:|.:|..||.|:...|.|:...|..::
Mouse   830 SFAGVFCILAIGLLLACLVAALELWWNSNRCHQE 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	65/282 (23%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	60/286 (21%)
Grid1	NP_032192.2	Interaction with CBLN1. /evidence=ECO:0000269\|PubMed:27418511	21..436		71/475 (15%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	70/457 (15%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	84/404 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..960
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846295
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840