DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and Gria4

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	XP_006509904.1	Gene:	Gria4 / 14802	MGIID:	95811	Length:	912	Species:	Mus musculus

Alignment Length:	903	Identity:	174/903 - (19%)
Similarity:	314/903 - (34%)	Gaps:	237/903 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 FYKNT-QETSILLIAI----TDSDCPRLPLNRALMVPIVENGDEF-------------------- 148
            |.:|| ||.:...:||    |..:....|.|....|..:|..:.|
Mouse    33 FIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGL 97

  Fly   149 ----------------------PQLILDAKVQQIL-----------------NWKTAVVFVD--- 171
                                  |....:.:.|.:|                 .|...|...|
Mouse    98 YDKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLRPSLRGALLSLLDHYEWNCFVFLYDTDR 162

  Fly   172 -----QTILE---ENALLVKSIVHESITNHITPISLILYEINDSLRGQQKRVA-------LRQAL 221
                 |.|:|   :|...|.:|..|:..:  .....:|.|::   |.|:|:..       |:..|
Mouse   163 GYSILQAIMEKAGQNGWHVSAICVENFND--VSYRQLLEELD---RRQEKKFVIDCEIERLQNIL 222

  Fly   222 SQFAPKKHEEMRQQFLVISAFHEDIIEIAETLNMF-HVGNQWMIFVLDMVARDFDAGTVTINLDE 285
            .|............:::.:...:||     :|..| |.|.....|.|    .||:...||..:|.
Mouse   223 EQIVSVGKHVKGYHYIIANLGFKDI-----SLERFIHGGANVTGFQL----VDFNTPMVTKLMDR 278

  Fly   286 GANI---AFALNETDPNCQDSLN----CTISEISLALVNAISKITVEEESIYGEI---SDEEW-E 339
            ...:   .:..:||.|....:|.    ..::|...:|..  .||.:......|:.   ....| :
Mouse   279 WKKLDQREYPGSETPPKYTSALTYDGVLVMAETFRSLRR--QKIDISRRGNAGDCLANPAAPWGQ 341

  Fly   340 AIRFTKQEKQAEILEYMKEFLKTNAKCSSCARWRVETAITWGKSQENRKFRSTPQRDAKNRNFEF 404
            .|...:..||..|     :.|..|.:.....| ||      ..:.:..:.:||..|
Mouse   342 GIDMERTLKQVRI-----QGLTGNVQFDHYGR-RV------NYTMDVFELKSTGPR--------- 385

  Fly   405 INIGYW-----------TPVLGFVCQELAFPHIEHHFRNITMDILTVHNPPWQILTKN-----SN 453
             .:|||           .|.||   .:.|      ...|.|:.:.|:...|:.:..||     .|
Mouse   386 -KVGYWNDMDKLVLIQDAPTLG---NDTA------AIENRTVVVTTIMESPYVMYKKNHEMFEGN 440

  Fly   454 GVIVEHKGIVMEIVKELSRALNFSYYLHEASAWKEEDSLSTSAGGNESD-ELVGSMTFRIPYRVV 517
            .   :::|..:::..|:::.:...|.:......|        .|..::| ::...|...:.|...
Mouse   441 D---KYEGYCVDLASEIAKHIGIKYKIAIVPDGK--------YGARDADTKIWNGMVGELVYGKA 494

  Fly   518 EMVQGNQFFIAAVAATVEDPDQKPFNYTQPISVQKYSFITRKPDEVS-RIYLFTAPFTVETWFCL 581
            |        ||....|:....::..::::|......|.:.:||.:.. .::.|..|...|.|.|:
Mouse   495 E--------IAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCI 551

  Fly   582 MGIILLTAPTLYAINRLAPL----------KEMRIVGLST-------VKSCFWYIFGALLQQGGM 629
            :...:..:..|:.::|.:|.          ||    |.|.       :.:..|:..||.:|||..
Mouse   552 VFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKE----GPSDQPPNEFGIFNSLWFSLGAFMQQGCD 612

  Fly   630 YLPTADSGRLVVGFWWIVVIVLVTTYCGNLVAFLTFPKFQPGVDYLNQLEDHKDIVQYGLRNGTF 694
            ..|.:.|||:|.|.||...::::::|..||.||||..:....::....|....:|....|.:|
Mouse   613 ISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSG-- 675

  Fly   695 FERYVQSTTREDFKHYLERAKI--------YGSAQEEDI------EAVKRGERINIDWRINLQLI 745
                   :|:|.|:    |:||        |..:.|..:      |.|.|..:....:...|:..
Mouse   676 -------STKEFFR----RSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLEST 729

  Fly   746 VQRHFEREKECHFALGRESFVDEQIAMIVPAQSAYLHLVNRHIKSMFRMGFIER-----WHQMNL 805
            :..:.|:.|.|.......:...:...:..|..|:....||..:..:...|.:::     |:
Mouse   730 MNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNKWWY---- 790

  Fly   806 PSAGKCNGKSAQRQVTNHKVNMDDMQGCFLVLLLGFTLALLIVCGEFWYRRFRASRKR 863
             ..|:|..|.:..:.....:::.::.|.|.:|:.|..||:|:...||.|:. ||..||
Mouse   791 -DKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKS-RAEAKR 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	60/291 (21%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	61/295 (21%)
Gria4	XP_006509904.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	72/404 (18%)
Gria4	XP_006509904.1	PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	82/421 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846428
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940