DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and GRIN3A

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_597702.2	Gene:	GRIN3A / 116443	HGNCID:	16767	Length:	1115	Species:	Homo sapiens

Alignment Length:	815	Identity:	142/815 - (17%)
Similarity:	282/815 - (34%)	Gaps:	240/815 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 ALSQFAPKKHEEMRQQFLVISAFHEDIIEIA------ETLNMFHVGNQWMIFVLDMVARDFDAGT 278
            ||..| |:...||.:..||....|..:|.|.      |:.|..|:    .:.:.:.::.|.|...
Human   195 ALLAF-PQSQGEMMELDLVSLVLHIPVISIVRHEFPRESQNPLHL----QLSLENSLSSDADVTV 254

  Fly   279 VTINLDEGANIAFALNETDPNCQDSLNCTISEISL---ALVN----------AISKITVEEESI- 329
            ..:.::...|.:..|.:.|.|..|.|..|.:....   :::|          .:|.:.::.|||
Human   255 SILTMNNWYNFSLLLCQEDWNITDFLLLTQNNSKFHLGSIINITANLPSTQDLLSFLQIQLESIK 319

  Fly   330 -------------------------YGEISDE-EW--------EAIRFTK----------QEKQA 350
                                     :|.:..| .|        |.:| |:          :..|:
Human   320 NSTPTVVMFGCDMESIRRIFEITTQFGVMPPELRWVLGDSQNVEELR-TEGLPLGLIAHGKTTQS 383

  Fly   351 EILEYMKEFLKTNAKCSSCAR---------------WRVETA-ITWGK----------------- 382
            ....|:::.::..|:..:.|.               ..|||. :|.|:
Human   384 VFEHYVQDAMELVARAVATATMIQPELALIPSTMNCMEVETTNLTSGQYLSRFLANTTFRGLSGS 448

  Fly   383 ---------SQENRKFRSTPQRDAKNRNFEFINIGYWTP---VLGF-VCQELAFPHIEH--HFRN 432
                     |.||..|....|.|...:.. :..:|.|..   |:.: :..|.|..|..|  |...
Human   449 IRVKGSTIVSSENNFFIWNLQHDPMGKPM-WTRLGSWQGGKIVMDYGIWPEQAQRHKTHFQHPSK 512

  Fly   433 ITMDILTVHNPPWQILTK---------------------------------NSNGVI-VEHK--- 460
            :.:.::|:...|: :.|:                                 :||..: ::.|
Human   513 LHLRVVTLIEHPF-VFTREVDDEGLCPAGQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCC 576

  Fly   461 -GIVMEIVKELSRALNFSYYLH-----EASAWKEEDSLSTSAGGNESDELVGSMTFRIPYRVVEM 519
             |..::::::::..:||.:.|:     :..|||         .|:.:. |||           ::
Human   577 YGYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWK---------NGHWTG-LVG-----------DL 620

  Fly   520 VQGNQFFIAAVAATVEDPDQKPFNYTQPISVQKYSFITRKPDEVSRIYLFTAPFTVETWFCLMGI 584
            ::|.. .:|..:.::.....:..::|.|........:.|..|..:.|..|..|.....|..:...
Human   621 LRGTA-HMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVA 684

  Fly   585 ILLTAPTLYAINRLAPLKEMRIVGL--------------STVKSCFWYIFGALLQQGGMYLPTAD 635
            :.:||..|......:|.      ||              |.:..|:..:||..:   .:..|...
Human   685 LHITAVFLTLYEWKSPF------GLTPKGRNRSKVFSFSSALNICYALLFGRTV---AIKPPKCW 740

  Fly   636 SGRLVVGFWWIVVIVLVTTYCGNLVAFLTFPKFQPGVDYLNQLEDHKDIVQYGLRNGTFFERYVQ 700
            :||.::..|.|..:..::||..||.|.:...|....:..::..:.|..  ..|.|.||..|...:
Human   741 TGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHP--SQGFRFGTVRESSAE 803

  Fly   701 STTREDFKHYLERAKIYG-SAQEEDIEAVKRG-ERIN--------IDWRINLQLIVQRHFEREKE 755
            ...|:.|....|..:.|. .|..:.:|.:|.. |:::        :|:.:::          :.:
Human   804 DYVRQSFPEMHEYMRRYNVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSI----------DAD 858

  Fly   756 CHFALGRESFVDEQIAMIVPAQSAYLHLVNRHIKSMFRMGFI----ERWHQMNLPSAGKCNGKSA 816
            |......:.|..|...:.:|..|.....::..|......||:    ::|::: :|    | ||.:
Human   859 CKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRV-VP----C-GKRS 917

  Fly   817 QRQVTNHKVNMDDMQGCFLVLLLGFTLALLIVCGE 851
            .......::.:....|.|::|.:||.|::|...||
Human   918 FAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGE 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	54/324 (17%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	52/287 (18%)
GRIN3A	NP_597702.2	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	52/308 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..118
		ANF_receptor	127..469	CDD:279440	47/279 (17%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	71/439 (16%)
		Lig_chan	676..942	CDD:278489	53/292 (18%)
		PPP2CB binding site. /evidence=ECO:0000250	951..987		2/2 (100%)
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1062..1095
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155992
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840