DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir93a and Grik4

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_780690.2	Gene:	Grik4 / 110637	MGIID:	95817	Length:	956	Species:	Mus musculus

Alignment Length:	919	Identity:	172/919 - (18%)
Similarity:	350/919 - (38%)	Gaps:	231/919 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EMRPSACLLLLAGLQLSILVPTEANDFSSFLSANASLAVVVDHEYMTVHGENILAHFEKILSDVI 69
            |...:.|.:|..|: :::|.|:.:...||.:|              .:.||..:.||:....:.:
Mouse    78 ETAETMCQILPKGV-VAVLGPSSSPASSSIIS--------------NICGEKEVPHFKVAPEEFV 127

  Fly    70 RENLRNGGINVKYFSWNAVRLKKDFLAAITVTDCENTWNFYKNTQETSILLIAITDSDCPRLPLN 134
            |..|:      ::.:.|......|...|:.     ...||:..|  |:.|:.|  .::| .|.|.
Mouse   128 RFQLQ------RFTTLNLHPSNTDISVAVA-----GILNFFNCT--TACLICA--KAEC-LLNLE 176

  Fly   135 RALMVPIVENGDEFPQLILDAK-----VQQILNWKTAVVFVDQTILEENALLVKSIVHESITNHI 194
            :.|...::.......:::.|.:     :::|.:.|||.:.:.......:.:|:|:.....::.:.
Mouse   177 KLLRQFLISKDTLSVRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYY 241

  Fly   195 TPISLILYEINDSLRGQQKRVALRQALSQFAPKKHEEMRQQFLVISAFHEDIIEIAETLNMFHVG 259
            |   .|...:..||:.....|..|..:..|:            :.:..|....|.:::||.....
Mouse   242 T---YIFTNLEFSLQRMDSLVDDRVNILGFS------------IFNQSHAFFQEFSQSLNQSWQE 291

  Fly   260 NQWMIFVLDMVARDFDAGTVTINLDEGANIAFALNETDPNCQ---DSLNCTISEI---SLALVNA 318
            |      .|.|.....|.:..:..|....:..|:.|.:.:.:   ..|:|..::|   ..:|:|.
Mouse   292 N------CDHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNY 350

  Fly   319 ISKITVE------EESIYGEISDEEWEAIRFTKQEKQAEILEYMKEFLKTNAKCSSCARWRVETA 377
            :..:.:|      |.:..|:.|:...:.::||:...|                  ...:|.|..
Mouse   351 LRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNGFQ------------------QIGQWHVAE- 396

  Fly   378 ITWGKSQENRKFRSTPQRDAKNRNFEFINIGYWTPVLGFVCQELAFPHIEHHFRNITMDILTVHN 442
               |.|.::|.:.|                                 :|.....|.|:.:.|:..
Mouse   397 ---GLSMDSRLYAS---------------------------------NISDSLFNTTLVVTTILE 425

  Fly   443 PPWQILTKN-----SNGVIVEHKGIVMEIVKELSRALNFSYYLHEASAWKEEDSLSTSAGGNESD 502
            .|:.:|..|     .|.   .::|..::::|||:..|.|:|.:
Mouse   426 NPYLMLKGNHQEMEGND---RYEGFCVDMLKELAEILRFNYKI---------------------- 465

  Fly   503 ELVGSMTFRIPY-------RVVEMVQGNQFFIAAVAATVEDPDQKPFNYTQP-----ISVQKYSF 555
            .|||...:.:|.       .|.|:: ..:..:|....|:....:|..::::|     ||:.....
Mouse   466 RLVGDGVYGVPEANGTWTGMVGELI-ARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVH 529

  Fly   556 ITRKPDEVSRIYLFTAPFTVETWFCLMGIILLTAPTLYAINRLAPLKEMR-----------IVGL 609
            :.|:|...|    |..||:...|..::...|..:..|:.:.||.|.:...           :|..
Mouse   530 MGRRPGYFS----FLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQ 590

  Fly   610 STVKSCFWYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIVLVTTYCGNLVAFLTFPKFQPGVDY 674
            .::.:..|:..|..:|||....|.|.|.|.|.|.||...::::::|..||.||||..:.:..::.
Mouse   591 YSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIES 655

  Fly   675 LNQLEDHKDIVQYGLRNG----TFFERYVQSTTREDFKH-YLERAKIYGSAQEEDIEAVKRGERI 734
            ::.|.| :..::||..:|    |||:.....|.:..:.: |.::..::..:.||.|..|     :
Mouse   656 VDDLAD-QTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARV-----L 714

  Fly   735 NIDWRINLQLIVQRHFEREKECH------------FALGR---ESFVDE-QIAMIVPAQSAYLHL 783
            |.::...|:..:..:: |::.|:            :.:|.   ..|.|| .:|::...::..|.:
Mouse   715 NSNYAFLLESTMNEYY-RQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEI 778

  Fly   784 VNRHIKSMFRMGFIERWHQMNLPSAGKCNGKSAQRQVTNHKVNMDDMQGCFLVLLLGFTLALLIV 848
            :.|            :|.:     .|||..:...|.   ..:.|:::.|.|:||:.|..:|:.:.
Mouse   779 LKR------------KWWE-----GGKCPKEEDHRA---KGLGMENIGGIFVVLICGLIVAIFMA 823

  Fly   849 CGEF-WYRR 856
            ..|| |..|
Mouse   824 MLEFLWTLR 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	67/299 (22%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	60/291 (21%)
Grik4	NP_780690.2	Periplasmic_Binding_Protein_type1	24..402	CDD:385651	69/397 (17%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	85/418 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846207
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940