DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir93a and LOC110438919

DIOPT Version :9

Sequence 1:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	XP_021328141.1	Gene:	LOC110438919 / 110438919	-ID:	-	Length:	1417	Species:	Danio rerio

Alignment Length:	790	Identity:	142/790 - (17%)
Similarity:	301/790 - (38%)	Gaps:	202/790 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 ILEENALLVKSIVHESITNHITPISLILYEINDSLRGQQKRVALRQALS--------QFAPKKHE 230
            |:||....:.|||......:...::.|...|.:|..|.:....|...:|        |...||
Zfish    19 IMEEYDWYIFSIVTTYYPGYQDFVTKIRSTIENSFVGWELEEVLLLDMSVDDGDAKIQNLLKK-- 81

  Fly   231 EMRQQFLVISAFHED---IIEIAETLNMFHVGNQWMIFVL-----DMVARDFDAGTVTINLDE-- 285
             ::...:::.:..|:   |.::|.::.:...|..|::..|     |.:..:|..|.::::.||
Zfish    82 -LQSPVILLYSTKEEANIIFQVAHSVGLTGYGYTWIVPSLVAGDADHIPAEFPTGMISVSYDEWD 145

  Fly   286 ---------GANIAFALNET-----------------DPNCQDSLNCTISEISLALVNAISKITV 324
                     |..:......|                 .|:.:..:....:|:...|:|    :|.
Zfish   146 YGLEARVRDGVAVIATATSTMMMDRGPHTLLKSECHGAPDKKSPMTGNNNEVLRYLMN----VTF 206

  Fly   325 EEESIYGEISDEEWE-----AIRFTKQEKQAEILEYMKEFLKTNAKCSSCARWRVETAITWGKSQ 384
            |..::  ..|::.::     .|....:|:|                      |  :....|....
Zfish   207 EGRNL--SFSEDGYQMHPKLVIILLDKERQ----------------------W--DRVGKWENGS 245

  Fly   385 ENRKFRSTPQRDAKNRNFEFINIGYWTPVLGFVCQELAFPHIEHHFRNITMDILTVHNPPWQIL- 448
            .:.|:...|:       ||..:        |...:|      :.|     :.|:|:...|:.|:
Zfish   246 LSMKYHVWPR-------FELYS--------GPEARE------DDH-----LSIVTLEEAPFVIVE 284

  Fly   449 -------------------------TKNSNGVIVEH--KGIVMEIVKELSRALNFSYYLHEASAW 486
                                     |::| .|.::.  ||..::|:|::::.:.|:|.|:..:..
Zfish   285 DVDPLSGTCMRNTVPCRKQLKALNQTQDS-AVYIKRCCKGFCIDILKKIAKNVKFTYDLYLVTNG 348

  Fly   487 KEEDSLSTSAGGNESDELVGSMTFRIPYRVVEMVQGNQFFIAAVAATVEDPDQKPFNYTQP---- 547
            |....::.:..|     :||.:..:..:            :|..:.|:.:...:..:::.|
Zfish   349 KHGKKINGTWNG-----MVGEVVLKNAH------------MAVGSLTINEERSEVIDFSVPFIET 396

  Fly   548 -ISVQKYSFITRKPDEVSRIYLFTAPFTVETWFCLMGIILL-TAPTLYAINRLAPLKEMRIV--- 607
             |||    .::|....||. ..|..||:.:.|..:..::|| :|..::.....:|:...|.:
Zfish   397 GISV----MVSRSNGTVSP-SAFLEPFSADVWIMMFVMLLLVSAIAVFIFEYFSPVGYNRCLADG 456

  Fly   608 ----GLS-TVKSCFWYIFGALLQQG-GMYLPTADSGRLVVGFWWIVVIVLVTTYCGNLVAFLTFP 666
                |.| |:....|.::|.:.... .:..|...:.:::|..|....::.:.:|..||.||:...
Zfish   457 REAGGPSFTIGKAIWLLWGLVFNNSVPVQNPRGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQE 521

  Fly   667 KFQPGVDYLNQLEDHK-----DI---VQYG-LRNGTFFERYVQSTTREDFKHYLERAKIYGSAQE 722
            ::   ||.::.|.|.|     |.   .::| :.||: .||.:::..| |...|:  .|.:.....
Zfish   522 EY---VDQVSGLSDKKFQNPNDFSPPFRFGTVPNGS-TERNIRNNYR-DMHSYM--VKFHQRNVV 579

  Fly   723 EDIEAVKRGERINIDWRINLQLIVQRHFEREKECHF-ALGR-ESFVDEQIAMIVPAQSAYLHLVN 785
            |.:|::|.|:   :|..|....::.....|::.|.. .:|. :.|......:.:...|.:...|:
Zfish   580 EALESLKTGK---LDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVD 641

  Fly   786 RHIKSMFRMGFIERWHQMNLPSAGKCNGKSAQRQVTNHKVNMDDMQGCFLVLLLGFTLALLIVCG 850
            ..|..:|..|.:|....:.|  .|.|:.:  :.:|.:.::::|:|.|.|.:|.....|:|:....
Zfish   642 LAILQLFGDGEMEELEALWL--TGICHHE--KNEVMSSQLDVDNMAGVFYMLGAAMALSLITFIA 702

  Fly   851 E---FWYRRF 857
            |   :|:.||
Zfish   703 EHVFYWHMRF 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	59/319 (18%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	58/280 (21%)
LOC110438919	XP_021328141.1	PBP1_iGluR_NMDA_NR2	<1..255	CDD:107373	41/268 (15%)
		PBP2_iGluR_NMDA_Nr2	267..667	CDD:270436	84/439 (19%)
		DUF4013	<389..478	CDD:315788	21/93 (23%)
		NMDAR2_C	704..1417	CDD:313729	3/9 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591350
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840