Protein Alignment Ir93a and grin2cb

DIOPT Version :9

• Sequence 1: NP_650924.3
• Gene: Ir93a / 42471
• FlyBaseID: FBgn0259215
• Length: 868
• Species: Drosophila melanogaster
• Sequence 2: XP_009305071.2
• Gene: grin2cb / 100333648
• ZFINID: ZDB-GENE-100308-2
• Length: 1328
• Species: Danio rerio
• Alignment Length: 987
• Identity: 177/987 - (17%)
• Similarity: 353/987 - (35%)
• Gaps: 258/987 - (26%)

  Fly     4 GEMRPSACLLLLAGLQLSILVPTEANDFSSFLSANASLAVVVDHEYMTVHG----ENIL------ 58
            |.:.||..||....|.|:::.......|....|.|.::.......:..:.|    ||.|
Zfish     6 GCLGPSLQLLFFFHLLLNVVPRCRGRPFFGPPSVNVAVVFSGSAHHSEIKGRLSPENFLDMPLEV 70

  Fly    59 -------------AHFEKILSDVIRENLRNGGINVKYFSWNAVRLKKDFLAAITVTDCENTWNFY 110
                         |...::...:..|:| :|.:........||....||:::
Zfish    71 NPITVLVNDTNPRALLTRLCQTMAAESL-HGVVFEDDVDSEAVAQILDFVSS------------- 121

  Fly   111 KNTQETSILLIAITDSDCPRLPLNRALMVPIVENGDEFPQLILDAKVQQILNWKTAVVFVDQTIL 175
                :|||.::.|:...        |:::|...:|..|.|  :.|.:.|.:|    .:|   .::
Zfish   122 ----QTSIPIVGISGGS--------AVVIPHKADGSTFLQ--MGASIDQQIN----AMF---KVM 165

  Fly   176 EE----NALLVKSIV--HESITNHI---TPISLILYEINDSLRGQQ----KRVALRQALSQFAPK 227
            ||    |.:::.|:.  :|:..::|   |..|..|:|:.|.|..:.    ..:..|:.|.|
Zfish   166 EEYNWGNFVVITSLYPGYETFVDYIRSFTDTSYFLWELQDVLSFEMSVGANDIRTRRLLQQ---- 226

  Fly   228 KHEEMRQQFLVISAFHED---IIEIAETLNMFHVGNQWMIFVLDMVARDFDAGTVTINLDEGANI 289
                :..|..::...||:   :..:|..:.:...|..|::                      .::
Zfish   227 ----VDSQVYLVYCSHEEAQYLFRMASDVGLLGPGYIWIV----------------------PSL 265

  Fly   290 AFALNETDPNCQDSLNCTISEISLALVNAISKITVEEESIYGEISDEEW-EAIRFTKQEKQAEIL 353
            |....|..|.....            |..||.||            :.| :.:|...:|..|.|:
Zfish   266 AVGNPEAAPPASFP------------VGVISIIT------------DRWRKTLRQRVREGVAIIV 306

  Fly   354 EYMKEFLK-------TNAKCSSCARWRVETAITWGKSQENRK-FRSTPQRDAKNRNFEFINIGYW 410
            :.:..|.|       .::.|||..           ||..|.. ||.......::::..|.:.||.
Zfish   307 KGVHSFHKHRGFIPEGHSDCSSPV-----------KSYANNSLFRHMLNVSWEHKDLSFNSDGYL 360

  Fly   411 T-PVLGFVC-----------------QELAFP-------HIEHHFRNITMDILTVHNPPWQIL-- 448
            | |.:..:.                 .::.:|       .:|....|..:.:.|:...|:.|:
Zfish   361 TNPSMVIIALDRENHWDKVGSYEGGILQMRYPVWPRYGSFLEPVSDNRHLTVATLEERPFVIVES 425

  Fly   449 -----------------TKNSNGVIVEH---------KGIVMEIVKELSRALNFSYYLHEASAWK 487
                             ..|....|:.|         ||..::|:|:|||.:.|||.|:..:..|
Zfish   426 VDPATGTCVRNTVPCRRQSNRTESIIGHTEPYTKLCCKGFCIDILKKLSRTIKFSYDLYLVTNGK 490

  Fly   488 EEDSLSTSAGGNESDELVGSMTFRIPYRVVEMVQGNQFFIAAVAATVEDPDQKPFNYTQPISVQK 552
            .         |.....:...|...:.|:..:|..|        :.|:.:...:..:::.|.....
Zfish   491 H---------GKMVRGVWNGMIGEVFYKRADMAIG--------SLTINEERSEIVDFSVPFVETG 538

  Fly   553 YSFITRKPDEVSRIYLFTAPFTVETWFCLMGIILLT--APTLYAINRLAPLKEMR-IVGLS---- 610
            .|.:..:.:.......|..|::...| .:|.::.||  |.|::.....:|:...| :|...
Zfish   539 ISVMVARSNGTVSPSAFLEPYSPAVW-VMMFVMCLTVVAVTVFVFEYFSPVGYNRSLVSAKAPGG 602

  Fly   611 ---TVKSCFWYIFGALLQQG-GMYLPTADSGRLVVGFWWIVVIVLVTTYCGNLVAFLTFPKFQPG 671
               |:....|.::|.:.... .:..|...:.:::|..|....::.:.:|..||.||:...::
Zfish   603 PTFTIGKSVWLLWGIVFNNSVPIENPKGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQY--- 664

  Fly   672 VDYLNQLED--------HKDIVQYG-LRNGTFFERYVQSTTREDFKHYLERAKIYGSAQEEDIEA 727
            :|.::.|.|        |....::| :.||: .||.::|...:...|.:   |......||.:.:
Zfish   665 IDTVSGLSDKKFQKPQEHYPPFRFGTVPNGS-TERNIRSNYPDMHTHMI---KYNQKGVEEALNS 725

  Fly   728 VKRGERINIDWRINLQLIVQRHFEREKECHF-ALGR-ESFVDEQIAMIVPAQSAYLHLVNRHIKS 790
            :|.|:   :|..|....::.....:::.|.. .:|. :.|......:.:...|.:...::..:..
Zfish   726 LKTGK---LDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIALQKDSRWKRPIDLALLQ 787

  Fly   791 MFRMGFIERWHQMNLPSAGKCNGKSAQRQVTNHKVNMDDMQGCFLVLLLGFTLALLIVCGE---F 852
            ....|..:|...:.|  :|.|  ::.:.:|.:.|:::|:|.|.|.:||:...|:||:...|   :
Zfish   788 FLGDGDTQRLETVWL--SGIC--QNEKNEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLLY 848

  Fly   853 WYRRFRASRKRR 864
            |..|....:..|
Zfish   849 WKLRHSVHKSDR 860

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	56/315 (18%)
		Lig_chan	576..836	CDD:306551	53/281 (19%)
grin2cb	XP_009305071.2	PBP1_iGluR_NMDA_NR2	37..396	CDD:107373	77/458 (17%)
		PBP2_iGluR_NMDA_Nr2	407..808	CDD:270436	76/432 (18%)
		NMDAR2_C	845..>932	CDD:313729	3/16 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591383
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930