DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15696 and HOXB13

DIOPT Version :9

Sequence 1:	NP_650921.1	Gene:	CG15696 / 42469	FlyBaseID:	FBgn0038833	Length:	179	Species:	Drosophila melanogaster
Sequence 2:	NP_006352.2	Gene:	HOXB13 / 10481	HGNCID:	5112	Length:	284	Species:	Homo sapiens

Alignment Length:	174	Identity:	40/174 - (22%)
Similarity:	70/174 - (40%)	Gaps:	51/174 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 AGDRYVGTNASLGVLQRLRASLPFHP--YAHPASYVS---KESGGSPPASAAEAQIPVYDWLQY- 71
            ||:.|.......       |..|.:|  |...|||:.   .::.|:|.....::.:||..:..:
Human   116 AGEEYPSRPTEF-------AFYPGYPGTYQPMASYLDVSVVQTLGAPGEPRHDSLLPVDSYQSWA 173

  Fly    72 -----------------------------TRYHPPKLPRALRQNAPAKRTPGRLPRIPFTPQQLQ 107
                                         :..|||        :|.|.|. ||..|||::..||:
Human   174 LAGGWNSQMCCQGEQNPPGPFWKAAFADSSGQHPP--------DACAFRR-GRKKRIPYSKGQLR 229

  Fly   108 ALENAYKESNYLSAEDANKLADSLELTNTRVKIWFQNRRARERR 151
            .||..|..:.:::.:...|::.:..|:..::.|||||||.:|::
Human   230 ELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKK 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15696	NP_650921.1	Homeobox	97..144	CDD:278475	13/46 (28%)
HOXB13	NP_006352.2	HoxA13_N	12..121	CDD:372013	2/4 (50%)
		HOX	216..272	CDD:197696	19/55 (35%)
		Interaction with DNA. /evidence=ECO:0000305\|PubMed:28473536, ECO:0000305\|Ref.8	217..246		9/28 (32%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000305\|PubMed:28473536	258..269		6/10 (60%)
		Interaction with DNA. /evidence=ECO:0000305\|PubMed:28473536, ECO:0000305\|Ref.8	270..273		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000