Protein Alignment Synd and HOF1

DIOPT Version :9

• Sequence 1: NP_001262786.1
• Gene: Synd / 42467
• FlyBaseID: FBgn0053094
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: NP_013746.1
• Gene: HOF1 / 855048
• SGDID: S000004635
• Length: 669
• Species: Saccharomyces cerevisiae
• Alignment Length: 675
• Identity: 120/675 - (17%)
• Similarity: 228/675 - (33%)
• Gaps: 218/675 - (32%)

  Fly    17 FWEPGN--YKRTTKRIEDGYKLCNDLQQLIQERADIEKGYAKSLRTWSKKWGELIEKGPEYGTTE 79
            ||:|.:  .......|..|.:.|:.:....::|:::||.||:.|...:.|..:.|....:||...
Yeast     9 FWDPNDNGVNILLGHISQGIRSCDSMILFFKQRSELEKDYARRLGAITGKLDKDIGTNMDYGKLN 73

  Fly    80 AAWKGVLTESERISDVHMKIKDNLCNDVNSQIKTWQKE-NYHHTLMQIKERKDLEDLFKKAQKPW 143
            ..:..||:..:..:..|.|..:.|...:.:..|.:... ...:|.:..|..:...|.|.| :|..
Yeast    74 ETFNVVLSVEKARAQSHSKQSEILFRQIYTDTKAFAANLQARYTTLSGKIERLRMDKFNK-KKGC 137

  Fly   144 AKLLAKVEKAKADYHSACKTERS---ATNQERNANADSSLSPDQVKKMHDRVQKTKDQVQKCREK 205
            ..|..|::.|:..:......|.:   |...|.|..        ::.|.....|:.|.|:...:::
Yeast   138 EVLQKKLQDAQIRFRDLQLNENNMIGAKRVEHNKR--------ELLKWESNSQEYKVQLDVLKQE 194

  Fly   206 YEQAIAEITKYNSVYIEDMTSVFEKCQTFEKTRLQFFKEIL--FNVHS----CLDLTKVQSLPQI 264
            |:.:       ...:|.:...:..:.|..|..|:.|.:..|  |...|    .|:.||:..|...
Yeast   195 YKAS-------QKFWIHEWAQLSCELQEMENARISFLQSKLQQFATSSMETYILEQTKMDMLTNH 252

  Fly   265 YEEFS-----HTINNADQQKDLKWWSNNHGINMAMNW-----------------------PSFVE 301
            ...|:     .|.:..:....||..::...:|.:.||                       .|.::
Yeast   253 LNSFTAADEISTFSKENGTGRLKHKTSKGDMNSSANWAQMSSISTTSKKTESYMDNIRKLSSQLK 317

  Fly   302 YTEEFRDIAKGNKSKEALPAAPITLINQ------------------------------------- 329
            .||..|.:|..:|.::.||:..:|:..|
Yeast   318 ETENKRKLASIDKYEKPLPSPEVTMATQFRNSTPVIRNETKVVANPTLSLRSSPVQLQSNVDDSV 382

  Fly   330 --------RPVA--------ED----------VHQEYPQTNSLKKNTST----LSSVSSRASVKS 364
                    ||:.        ||          ||:.....:|..:::|:    .|.:..|.|::|
Yeast   383 LRQKPDKPRPIVGEEQLKPDEDSKNPDEKGLMVHKRNQSLSSPSESSSSNPTDFSHIKKRQSMES 447

  Fly   365 EIATTQSSVTTS------------------EAKTSAAVAGAATATAAATAASAASNRNSSVTNGN 411
             :.|:.||:..|                  ::.:...|..:|::.:.....:..|..|.:..:.|
Yeast   448 -MTTSVSSMANSIDDSQRFAKSWNSSNRKRKSMSHLQVPSSASSRSDDGGRTPNSAHNLNEDDYN 511

  Fly   412 GKVD--------------------------------ANPFDE---EEEWDESD--------NVLV 433
            .:.|                                :||.::   |.|..:|.        |::.
Yeast   512 TRRDTSTSTILFKPPVAVRGTSRGHTHRQSMIMQDSSNPIEDALYEMERIQSSSKPGTKTGNIMD 576

  Fly   434 DNG---------------EPGVPV----KALYDYEGAESDEL-TFKQGD--VFEKLEDEDEQGWC 476
            :.|               ..|.||    ||:|...|.|:..| .|.:||  :..::.::|   |.
Yeast   577 ERGVVRDRGITVTLPIVTSEGFPVIEYAKAMYPLIGNEAPGLANFHKGDYLLITEIVNKD---WY 638

  Fly   477 KGRM--------NGRVGLYPANYVE 493
            ||.:        |.|:||.|.|:::
Yeast   639 KGEVYDNDRIDRNHRIGLIPYNFIQ 663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Synd	NP_001262786.1	F-BAR_PACSIN	17..272	CDD:153339	53/271 (20%)
		SH3_PACSIN	441..493	CDD:212777	21/66 (32%)
HOF1	NP_013746.1	FCH	8..92	CDD:214492	19/82 (23%)
		SMC_prok_B	<110..>233	CDD:274008	25/138 (18%)
		SH3	600..663	CDD:214620	20/65 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23065
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010